The effect of mad honey on testosterone levels of male rats

Tatlı, Özgür; Karaca, Yunus; Turkmen, Süha; Gulgen, G.; Şahin, Ahmet; Eryiğit, Umut; Fazli, Ömer; Karagüzel, Ersagun; Menteşe, Ahmet; Örem, Asım; Cansu, Ali; Türedi, Süleyman; Gunduz, Abdülkadir

doi:10.4149/bll_2016_130

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…It was also shown that oral consumption of Tribulus terrestris could significantly reverse the reduction of sex hormones and gonadotropins in the male rats due to the morphine addiction [ 50 ]. Similar results have been obtained in some recent studies of sexual functioning with different antioxidant-acting compounds, in terms of FSH, LH, and testosterone levels [ 51 , 52 ].…”

Section: Discussionsupporting

confidence: 90%

MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

Şahin

Tuzcu

Orhan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Mucuna pruriens, Ashwagandha, and Tribulus terrestris are known as the enhancers for sexual health, functional activities, vitality, and longevity. These herbs had been widely used in the Ayurveda medicine as aphrodisiacs through the ages, and their efficacy was also verified separately in our previous publication. Therefore, the aim of this study was to determine the effects of Mucuna, Ashwagandha, and Tribulus complexes on sexual function in rats. Twenty-eight male rats allocated to four groups as follows: (i) negative control (C); (ii) positive control or sildenafil citrate treated group (5 mg/kg) (S); (iii) MAT1 (combination of 10 mg Mucuna (M) + 10 mg Ashwagandha (A) + 10 mg Tribulus (T)/kg BW); (iv) MAT 2 (20 mg Mucuna + 20 mg Ashwagandha + 20 mg Tribulus/kg BW). There was no significant difference found between the MAT1 and MAT2 groups while they showed significantly increased testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels when compared to the negative control. Significant increases in Nrf2/HO1 levels and decreases in NF-κB were detected in MAT groups similar to the decrease in serum and testis malondialdehyde (MDA) levels as compared to both controls. The sperm motility, count, and rate also significantly improved in both MAT groups, while ALT, AST, creatinine, ALP, and urea levels did not change in any of the groups. Oral consumption of MATs combination in male rats resulted in inhibition of NF-κB and MDA and also increased sex hormones with Nrf2-mediated HO-1 induction. MAT combinations may improve sexual functions by increasing levels of sexual hormones and regulation of NF-κB and Nrf2/HO-1 signaling pathways.

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Section: Discussionsupporting

confidence: 90%

MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

Şahin

Tuzcu

Orhan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Similar to our findings, pretreatment of animals with Tribulus terrestris and Mucuna pruriens alone and in combination was found to increase testosterone, FSH, and LH concentrations [29,30]. Comparable results have been reported on sexual functioning with different compounds, demonstrating increase of FSH, LH, and testosterone levels [31,32]. At dose 150 mg/kg plasma level of testosterone was significantly increased compared to distilled water treated group, but the LH level was less significant, suggesting that some constituents of Allium cameleon could be able to mimic the role of LH and stimulate Leydig cells to produce testosterone.…”

Section: Discussionsupporting

confidence: 90%

Allium cameleon extract improved androgenesis and sexual behavior in male rat (Rattus norvegicus) via attenuation of oxidative damages increased sexual hormone and NO/cGMP cascade

ZIGLA¹,

Augustin²,

Sidiki³

et al. 2022

GSC Biol. Pharm. Sci.

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Objective: Allium cameleon Cronquist (1981) (Liliaceae) is a bulb belonging to the garlic family, known as a medicinal plant used for its aphrodisiac activities in Cameroonian folk medicine. The present study was conducted to assess the aphrodisiac potentials of Allium cameleon aqueous extracts and investigate on the possible mechanisms by which this could be accomplished. Methods: The behavioral and biochemical tests were used to detect the aphrodisiac properties. The conceivable mechanisms of action of the aqueous extracts were investigated through determination of sexual hormones, nitric oxide, cGMP, and antioxidant activities in male rats treated with different plant extract concentrations. Results: Allium cameleon enhanced sexual excitement, improved semen quality, and the concentrations of testosterone, FSH and LH. Levels of endogenous antioxidant enzymes (CAT, SOD, and GSH) were improved. Penile nitric oxide and cGMP levels were boosted. Significant stimulation in sexual behavior, elevated spermatic production, raised of viability, morphology, count and sperm mobility were also observed. Treated animals exhibited elevated levels of endogenous antioxidant enzymes. Conclusion: These findings suggest that Allium cameleon possess aphrodisiac properties in rats that might be involve in the attenuation of oxidative damage, but also in the increase of sexual hormones production and NO/cGMP cascade.

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“…This toxin-containing honey is known locally as "mad honey" [2]. People in this region use locally produced honey as an alternative therapy for wound healing, to treat arthritis, stomach pain, intestinal diseases, and hypertension, and to increase sexual performance [3,4].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing

et al. 2018

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Objectives: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of “mad honey” and propolis on fracture healing using radiological and histopathological analysis. Subjects and Methods: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15- and 30-day) and 6 treatment groups (15- and 30-day normal honey, 15- and 30-day “mad honey,” and 15- and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed. Results: Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing “mad honey” group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and “mad honey” group (p = 0.007) were compared to the control group. Conclusions: This study shows that grayanotoxin-containing “mad honey” and propolis can accelerate fracture healing.

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The effect of mad honey on testosterone levels of male rats

Cited by 5 publications

References 11 publications

MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO‐1 Pathway While Reducing Oxidative Damage in Male Rats

Allium cameleon extract improved androgenesis and sexual behavior in male rat (Rattus norvegicus) via attenuation of oxidative damages increased sexual hormone and NO/cGMP cascade

A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing

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