The effect of magnetic field exposure on differentiation of magnetite nanoparticle-loaded adipose-derived stem cells

Lăbuşcă, Luminiţa; Herea, Dumitru-Daniel; Danceanu, Camelia-Mihaela; Minuti, Anca Emanuela; Stavila, Cristina; Grigoraş, M.; Ghercă, Daniel; Stoian, George; Chiriac, H.; Lupu, Nicoleta

doi:10.1016/j.msec.2020.110652

Cited by 34 publications

(29 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ADSCs- MNPs under MF exposure could thus be used for enabling osteoblastic conversion during cell therapy for systemic osteoporosis. Therefore, further in vivo studies are needed to discover ways to treat osteoporosis [ 133 ].…”

Section: Mnp Toxicity In Vitro and In Vivomentioning

confidence: 99%

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

et al. 2020

View full text Add to dashboard Cite

The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.

show abstract

Section: Mnp Toxicity In Vitro and In Vivomentioning

confidence: 99%

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although another study found that while magnetic field exposure does not inhibit stem cell differentiation and proliferation, magnetic field exposure can change the development of stem cells. [ 245 ] Short term exposure (2 days) with 7 Hz and 0.5 mT intensity increase adipogenesis, whereas long term (7 days) continuous or intermittent exposure facilitates osteogenesis. [ 245 ] In‐vivo study in rat brain cells confirmed the presence of cells even after 1 month of administration of nCP: Fe labeled mesenchymal stem cells using T 2 weighted dark contrast.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…[ 245 ] Short term exposure (2 days) with 7 Hz and 0.5 mT intensity increase adipogenesis, whereas long term (7 days) continuous or intermittent exposure facilitates osteogenesis. [ 245 ] In‐vivo study in rat brain cells confirmed the presence of cells even after 1 month of administration of nCP: Fe labeled mesenchymal stem cells using T 2 weighted dark contrast. [ 245 ] The lower r 2 value of the nanocomposite did not impair the detectable range of the nanocomposite; thus, nCP: Fe can potentially be used in stem cell tracking using an MRI contrast agent in vivo.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

show abstract

“…Another possibility to positively influence cell differentiation is mechanotransduction. The application leads to a conversion of an external force acting on a cell into internal biochemical signaling pathways and affects cell differentiation, proliferation and ECM composition, among others, and can be used in regenerative medicine for tissue-forming approaches [ 319 , 320 , 321 ]. Hu et al developed a Magnetic Force Bioreactor for ex vivo induced bone formation by magneto–mechanical stimulation, capable of activating specific cell surface receptors, such as platelet-derived growth factor receptor α (PDGFRα), using IONPs [ 322 ].…”

Section: Hard and Connective Tissue Regeneration And Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

View full text Add to dashboard Cite

In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

show abstract

The effect of magnetic field exposure on differentiation of magnetite nanoparticle-loaded adipose-derived stem cells

Cited by 34 publications

References 37 publications

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review

Recent progress of magnetic nanoparticles in biomedical applications: A review

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Contact Info

Product

Resources

About