“…The long-held tenet in TKA of restoration of a neutral overall mechanical axis (OMA) is supported by numerous biomechanical [28], finite element [2,44], and clinical studies [5,17,27,35,47,48,52,70,84], both historical and contemporary, demonstrating increased strain, higher failure rates, and, in many cases, lower functional scores with coronal malalignment. Recently, three-dimensional imaging and custom manufacturing have enabled the development of patient-specific positioning guides (PSPGs).…”