The present paper aims to analyze the influence of process parameters (tool traverse speed and tool rotational speed) on the macrostructure, microhardness, and mechanical properties of dissimilar friction stir welded (FSW) butt joints. Nine combinations of FSW parameters welded joints of aluminum alloys 7020-T651 and 5083-H111 were characterized. Plates in 5 mm thickness were welded using the FSW method as dissimilar joints with three values of tool rotation parameters (400, 800, and 1200 rpm) and three welding speeds (100, 200, 300 mm/min). The macroscopic observations revealed various shapes of the stir zone and defects resulting from excess and insufficient heat input. Microfractographic analysis and tensile test results showed that the samples made with the FSW parameters of 800 rpm and 200 mm/min had the best strength properties: UTS = 303 MPa, YS = 157 MPa, and A = 11.6 %. Moreover, for all welds at welding speed 100 mm/min, the joint efficiency reached 95%.