The Effect of Medication Samples on Self-Reported Prescribing Practices: A Statewide, Cross-Sectional Survey

Pinckney, Richard G.; Helminski, A. Shams; Kennedy, Amanda G.; MacLean, Charles D.; Hurowitz, Laurie; Cote, Elizabeth

doi:10.1007/s11606-010-1483-x

Cited by 21 publications

(39 citation statements)

References 12 publications

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“…Clinicians who did not have samples in their offices were more likely to prescribe hypertension medication according to clinical practice guidelines (p<0.01), and more likely to prescribe a depression medication that was generic (p = 0.02) [19]. Multivariable regression models were conducted only for the hypertension vignette.…”

Section: Resultsmentioning

confidence: 99%

Association between physicians’ interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis

et al. 2017

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BackgroundPharmaceutical company representatives likely influence the prescribing habits and professional behaviors of physicians. The objective of this study was to systematically review the association between physicians’ interactions with pharmaceutical companies and their clinical practices.MethodsWe used the standard systematic review methodology. Observational and experimental study designs examining any type of targeted interaction between practicing physicians and pharmaceutical companies were eligible. The search strategy included a search of MEDLINE and EMBASE databases up to July 2016. Two reviewers selected studies, abstracted data, and assessed risk of bias in duplicate and independently. We assessed the quality of evidence using the GRADE approach.ResultsTwenty articles reporting on 19 studies met our inclusion criteria. All of these studies were conducted in high-income countries and examined different types of interactions, including detailing, industry-funded continuing medical education, and receiving free gifts. While all included studies assessed prescribing behaviors, four studies also assessed financial outcomes, one assessed physicians’ knowledge, and one assessed their beliefs. None of the studies assessed clinical outcomes. Out of the 19 studies, 15 found a consistent association between interactions promoting a medication, and inappropriately increased prescribing rates, lower prescribing quality, and/or increased prescribing costs. The remaining four studies found both associations and lack of significant associations for the different types of exposures and drugs examined in the studies. A meta-analysis of six of these studies found a statistically significant association between exposure and physicians’ prescribing behaviors (OR = 2.52; 95% CI 1.82–3.50). The quality of evidence was downgraded to moderate for risk of bias and inconsistency. Sensitivity analysis excluding studies at high risk of bias did not substantially change these results. A subgroup analysis did not find a difference by type of exposure.ConclusionThere is moderate quality evidence that physicians’ interactions with pharmaceutical companies are associated with their prescribing patterns and quality.

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Section: Resultsmentioning

confidence: 99%

Association between physicians’ interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis

et al. 2017

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“…17 Various drug prescription problems have been identified in health facilities in developing countries like Nigeria. This includes irrational use of drugs, unnecessary polypharmacy and high use of drugs with unproven efficacy.…”

Section: Discussionmentioning

confidence: 99%

Utilization of antibiotics among physicians in the general outpatient unit of a tertiary health facility in North Central Nigeria

2018

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“…On the other hand, samples have the potential to increase costs and the use of brand name drugs. 10,[28][29][30] It is possible, in fact, that lower income seniors are receiving fewer samples precisely because they have higher rates of generic drug use, and that increasing the use of samples among this group might increase their use of more expensive medications.…”

Section: Discussionmentioning

confidence: 99%

Use of Prescription Drug Samples and Patient Assistance Programs, and the Role of Doctor–Patient Communication

Gellad

Huskamp

et al. 2011

J GEN INTERN MED

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The Effect of Medication Samples on Self-Reported Prescribing Practices: A Statewide, Cross-Sectional Survey

Abstract: Clinicians with samples in their clinics were less likely to prescribe preferred medications for hypertension and depression.

Cited by 21 publications

References 12 publications

Association between physicians’ interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis

Association between physicians’ interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis

Utilization of antibiotics among physicians in the general outpatient unit of a tertiary health facility in North Central Nigeria

Use of Prescription Drug Samples and Patient Assistance Programs, and the Role of Doctor–Patient Communication

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