The effect of melatonin on acetylsalicylic acid-induced kidney and testis damage

Altıntaş, Ramazan; Polat, Alaaddin; Parlakpınar, Hakan; Vardı, Nigar; Beytur, A.; Oğuz, Fatih; Sağır, Mustafa; Yıldız, Azibe; Duran, ZR

doi:10.1177/0960327113506240

Cited by 13 publications

(7 citation statements)

References 42 publications

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“…Our observations are consistent with earlier studies of melatonin effects on antioxidants [33][34][35][36][37]. We investigated earlier the protective and therapeutic effects of melatonin treatment against ASA induced kidney and testis damage [38]. We found that ASA increased MDA levels in both kidney and testis significantly, whereas it decreased the levels of SOD, CAT, GPx and GSH significantly in the kidney and CAT levels in testis.…”

Section: Discussionsupporting

confidence: 91%

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Sarıhan¹,

Parlakpınar²,

Polat³

et al. 2017

Med-Science

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We investigated the effects of acute high doses of acetylsalicylic acid (ASA) on liver tissue and the protective and therapeutic effects of melatonin on ASA related damage. Forty rats were randomly divided into five groups of eight: group 1, control; group 2, administered 200 mg/kg ASA; group 3, administered 5 mg/kg melatonin 45 min before ASA; group 4, administered 5 mg/kg melatonin 45 min after ASA; group 5, administered 5 mg/kg melatonin. We measured malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), myeloperoxidase (MPO) aspartate aminotransferase (AST) and alanine transaminase (ALT) in the liver. ASA treatment significantly increased MDA and MPO production, whereas it significantly decreased levels of SOD, CAT, GPx and GSH in the liver. Melatonin significantly decreased MDA and MPO production, whereas it caused increased levels of antioxidants. AST and ALT levels were higher after ASA treatment, whereas these levels were reduced significantly after melatonin administration. Our histopathological findings, including apoptosis, were consistent with the biochemical results. Melatonin exhibits beneficial effects against high dose ASA induced hepatotoxicity.

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Section: Discussionsupporting

confidence: 91%

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Sarıhan¹,

Parlakpınar²,

Polat³

et al. 2017

Med-Science

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“…The dead cells, which release ROS, and pro-and anti-inflammatory cytokines, and endothelial and macrophage-like cells activated by ionic reactions, can lead to this inflammatory response that can last a long time and causes irreversible tissue damage. 47 Our study demonstrated that ISO was a powerful oxidizing agent that caused a significant oxidative damage in the rat heart tissue. Additionally, our study showed that DEX could potentially be used as a treatment to prevent oxidative damage by ISO.…”

Section: Discussionmentioning

confidence: 57%

“…More recently, we highlighted that oxidative stress, due to the overproduction of ROS and a decrease in the antioxidant level, causes membrane lipid peroxidation, oxidation of cell proteins, damage within the DNA helix and cell death, and also initiates an inflammatory response cascade. The dead cells, which release ROS, and pro‐ and anti‐inflammatory cytokines, and endothelial and macrophage‐like cells activated by ionic reactions, can lead to this inflammatory response that can last a long time and causes irreversible tissue damage . Our study demonstrated that ISO was a powerful oxidizing agent that caused a significant oxidative damage in the rat heart tissue.…”

Section: Discussionmentioning

confidence: 60%

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Kalkan

Parlakpınar

Disli

et al. 2018

J of Cellular Biochemistry

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The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO ), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.

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“…The administration of melatonin reduced both adverse conditions [15]. This protective effect of melatonin has been reported against oxidative damage induced by aluminum in rats’ kidneies [16], acetylsalicylic acid-induced kidney and testis damage [17], decreased urinary excretion of n-acetyl-bd-glucosaminidase, and albumin and renal oxidative markers in diabetic rats [18].…”

Section: Introductionmentioning

confidence: 93%

Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs

Mogheiseh

Koohi

Nazifi

et al. 2019

Basic Clin. Androl.

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BackgroundsMelatonin has significant antioxidant and hepatoprotective effects in normal and oxidative stress conditions. The aim of the present study was to assess the effects of melatonin on antioxidant, hepatic, and renal factors in intact and castrated dogs. Twenty male mixed-breed adult dogs were aligned in an experimental randomized and controlled trial. The dogs were randomly divided into four equal groups: melatonin, castrated, castrated and melatonin, and control. They were treated with melatonin (0.3 mg/Kg, once daily, orally) immediately after the castration for 1 month and their blood samples were collected weekly from 2 days after treatment with melatonin.ResultsTreating castrated dogs with melatonin increased the level of glutathione peroxidase, superoxide dismutase, and catalase compared with that of the control and castrated groups. The malondialdehyde level increased significantly following castration. Melatonin treatment decreased malondialdehyde concentration in the castrated dogs. Castration increased the level of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase significantly in comparison with that of the control group. Treating the castrated dogs with melatonin decreased significantly liver enzymes compared with those of the castrated dogs. Blood urea nitrogen and creatinine levels increased in the castrated dogs in comparison with that of the control group.ConclusionsThe administration of melatonin in castrated dogs increased antioxidant activity and decreased oxidation products, compared with those of the castrated and untreated dogs, without adverse effects on liver enzymes and kidney function.

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The effect of melatonin on acetylsalicylic acid-induced kidney and testis damage

Cited by 13 publications

References 42 publications

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Beneficial effects of melatonin on acetylsalicylic acid induced liver damage in rats

Protective and therapeutic effects of dexpanthenol on isoproterenol‐induced cardiac damage in rats

Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs

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