The effect of menopause on serum uric acid levels in non-obese healthy women

Wingrove, Callum S.; Walton, Christopher; Stevenson, John C.

doi:10.1016/s0026-0495(98)90056-7

Cited by 76 publications

(68 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study, however, is the first to report a gender difference, demonstrating that the prevalence remains constant at any age in men, whereas it decreases with age in women. Although the reason for this is unclear, a possible role of estrogen has been suggested, given that serum uric acid levels increase after menopause [27,28,29]. Because 80% of Japanese women undergo menopause between the ages 45 and 54 [30], menopausal status may explain the decrease in prevalence of hypouricemia with age in women.…”

Section: Discussionmentioning

confidence: 99%

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan

Wakasugi¹,

Kazama²,

Narita³

et al. 2015

Am J Nephrol

View full text Add to dashboard Cite

Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine the relationship between hypouricemia and reduced kidney function, defined as estimated glomerular filtration rate <60 ml/min/1.73 m². Results: Among 90,710 men (mean age, 63.8 years) and 136,935 women (63.7 years), 193 (0.2%) and 540 (0.4%) were identified as having hypouricemia, respectively. The prevalence of hypouricemia decreased with age in women (p for trend <0.001), but not in men (p for trend = 0.24). Hypouricemia was associated with reduced kidney function in men (odds ratio, 1.83; 95% confidence interval, 1.23-2.74), but not in women (0.61; 0.43-0.86), relative to the reference category (i.e., serum uric acid levels of 4.1-5.0 mg/dl) after adjusting for age, drinking, smoking, diabetes, hypertension, hypercholesterolemia, obesity, and history of renal failure. Sensitivity analyses stratified by diabetic status yielded similar results. Conclusions: This study is the first to provide evidence that hypouricemia is associated with reduced kidney function in men. Further research will be needed to determine the long-term prognosis of individuals with hypouricemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan

Wakasugi¹,

Kazama²,

Narita³

et al. 2015

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…31 The rates of MetS and hyperuricemia were consistently greater in women of postmenopausal age than in premenopausal women, which implied menopausal status potentially had an impact on the relationship between uric acid and MetS components. [32][33] Increases in serum acid in postmenopausal women may result from changes in metabolism as a consequence of the menopause. 33 Premenopausal levels of estrogens in women might promote more efficient renal clearance of urate; also, the administration of estrogen therapy to men was shown to decrease serum uric acid levels.…”

Section: Obesity and Uric Acidmentioning

confidence: 99%

“…[32][33] Increases in serum acid in postmenopausal women may result from changes in metabolism as a consequence of the menopause. 33 Premenopausal levels of estrogens in women might promote more efficient renal clearance of urate; also, the administration of estrogen therapy to men was shown to decrease serum uric acid levels. 34,35 In the present analysis, the path coefficients from uric acid to blood pressure were negative even after taking the indirect paths through lipid profile and hyperglycemia in men.…”

Section: Obesity and Uric Acidmentioning

confidence: 99%

Relationship between serum uric acid and metabolic syndrome: An analysis by structural equation modeling

Song

Wang

et al. 2012

Journal of Clinical Lipidology

View full text Add to dashboard Cite

“…The incidence of CVD in women is significantly higher after menopause [1]. Previous studies have found that the serum uric acid level is higher in postmenopausal women compared to premenopausal women [2], and menopause leads to an increase in serum uric acid [3]. Although recent epidemiologic studies suggest that serum uric acid is a relevant marker for cardiovascular disease [4][5][6], it is still controversial whether hyperuricemia is an independent risk factor for atherosclerosis [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women

Park¹,

Kang²,

Ahn³

et al. 2012

Maturitas

View full text Add to dashboard Cite

The effect of menopause on serum uric acid levels in non-obese healthy women

Cited by 76 publications

References 14 publications

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan

Association between Hypouricemia and Reduced Kidney Function: A Cross-Sectional Population-Based Study in Japan

Relationship between serum uric acid and metabolic syndrome: An analysis by structural equation modeling

Relationships between serum uric acid, adiponectin and arterial stiffness in postmenopausal women

Contact Info

Product

Resources

About