The effect of methlyprednisolone on pain, trismus, and swelling after removal of third molars

Effect of Single Dose Intramuscular Methylprednisolone Injection into the Masseter Muscle on the Surgical Extraction of Impacted Lower Third Molars: a Randomized Controlled Trial

“…7 Various studies have shown that when glucocorticoid are administered parentally and preoperatively, the marked reduction in inflammation and trismus can be achieved in the postoperative period. 15,16,25,[27][28][29] The same was observed in present study.…”

“…15,18 Rebound swelling can occur if the duration of use of steroid is inadequate; therefore, it is important to maintain levels of short-duration steroids formulations for more than one day. 14,16 So to prevent the rebound oedema, a sustained release form of steroid, such as methylprednisolone acetate in a higher single dose of 40 mg should be used,as in the present study. 17 Long-term use of steroids can delay healing and increase susceptibility to infection, but these effects are not clinically significant with the typical short-term usage protocols in oral surgery.…”

“…16 The acetate forms of this drug have low solubility that acts as a sustained-release depot, giving these forms some clinical advantage when a longer effect is needed. 17 In the present study, a single dose of 40 mg (1cc) methyprednisolone was selected.…”

Comparison of Efficacy of Methylprednisolone Injection into Masseter Muscle Versus Gluteal Muscle for Surgical Removal of Impacted Lower Third Molar

“…With a half life of 18-36 h, methylprednisolone is more potent than hydrocortisone and has no mineralocorticoid activity [4,5,7,11,12,13]. Though literature states that the site of administration has no impact, studies have been conducted to assess the efficacy of the steroid injection in various sites of administration [6]. The more comfortable route for the patients has been reviewed as the oral route, but its efficacy compared with the parenteral route is not predictable [8].…”

“…This reduces release of arachidonic acid from tissue phospholipids and decreases the formation of thromboxane, leukotrienes, prostacyclin and prostaglandins [4]. The glucocorticoids, especially methyl prednisolone was found to be effective as an anti-inflammatory mediator in surgical procedures and is commonly used to reduce the swelling associated with the surgical removal of impacted third molars [5][6][7][8][9][10][11][12].…”