The Effect of Methohexitone on Myocardial Blood Flow and Oxygen Consumption in the Dog

McMillan, Julie; Brown, Daniel F.; Smith, G.; Vance, J.P.

doi:10.1093/bja/46.10.729

Cited by 1 publication

(1 citation statement)

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“…Our experimental data (in the cat) indicate that the increase in HR is a direct effect of the drug and not related to baroreflex mechanisms (23). The effects of methohexital on the heart and systemic vascular resistance seem to vary according to dose but above all depending on the populations of patients studied (22,(24)(25)(26)(27). Very high infusion rates (24 mg * kg-'h-I) in neurosurgical patients were associated with a 24% reduction in SVR and no change in CO (26).…”

Section: Discussionmentioning

confidence: 78%

Anesthetic modulation of the cardiovascular response to microlaryngoscopy

Sellgren

Ejnell

Pontén

et al. 1995

Acta Anaesthesiol Scand

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The modulating effects of propofol versus methohexital on the cardiovascular response to microlaryngoscopy were studied in 35 patients divided into four equal groups (one patient participated twice). Heart rate (HR), mean arterial blood pressure (MAP, cardiac output (CO; impedance cardiography), leg blood flow (LBF; occlusion plethysmography) and concentrations of arterial catecholamines were measured. After administration of atropine and fentanyl (2 micrograms.kg-1), anesthesia was induced by either an injection of propofol (2.0 mg.kg-1) followed by a low (6 mg.kg-1.h-1; n = 9) or a high (12 mg.kg-1.h-1; n = 9) dose propofol infusion or an injection of methohexital (1.5 mg.kg-1) followed by a low (5 mg.kg-1.h-1; n = 9) or a high (10 mg.kg-1.h-1; n = 9) dose methohexital infusion. The low methohexital infusion dose was insufficient to control MAP, which increased 41% during microlaryngoscopy compared to the awake state. The HR increased in all groups but the increase was most prominent in the low dose methohexital group. There were no statistically significant changes in CO in any group, whereas LBF increased consistently in all groups except in patients anesthetized with the low dose of methohexital. The increases of LBF in the propofol groups were intermediate and not dose dependent. The methohexital low dose group showed increases in norepinephrine levels compared to awake values and in epinephrine levels compared to the other groups. Propofol seems to differ from methohexital in modulation of peripheral vascular tone.(ABSTRACT TRUNCATED AT 250 WORDS)

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