The Effect of Midlife Physical Activity on Cognitive Function Among Older Adults: AGES—Reykjavik Study

Chang, Milan; Jónsson, Pálmi V.; Snædal, Jón; Björnsson, Sigurbjörn; Saczynski, Jane S.; Aspelund, Thor; Eiríksdóttir, Guðný; Jónsdóttir, Marıá K.; López, Oscar L.; Harris, Tamara B.; Gudnason, Vilmundur; Launer, Lenore J.

doi:10.1093/gerona/glq152

Cited by 158 publications

(150 citation statements)

References 36 publications

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“…The limitation of the relationship between physical activity and dementia/AD in the present investigation only to noncarriers of the APOEε4 allele is consistent with observations in the Cardiovascular Health Cognition Study (17) and the AGES Study (18). Previous studies have shown that APOEε4 carriers do not derive the same blood pressure and lipid benefits from physical activity as noncarriers (32,33).…”

Section: Discussionsupporting

confidence: 81%

“…The suggestion of diminishing returns with greater amounts of physical activity is also consistent with findings from two studies with follow-up of more than 20 years (3,18). Therefore, it is necessary for future studies to stratify by level of physical activity, or use nonlinear modeling, to accurately assess this relationship.…”

Section: Discussionsupporting

confidence: 75%

“…However, given that in the Cardiovascular Health Cognition and the Age Gene/Environment Susceptibility-Reykjavik (AGES) studies the relationship between physical activity and risk of dementia was observed only in APOEε4 noncarriers (17,18), while the CAIDE (Cardiovascular Risk Factors, Aging and Incidence of Dementia) Study found an inverse relationship between physical activity and cognitive decline primarily in APOEε4 carriers (3), we decided a priori to construct separate models for ε4 carriers and noncarriers. We also decided a priori to perform analyses stratified by age (<75 years vs 75+ years).…”

Section: Statistical Analysesmentioning

confidence: 99%

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Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

Tan

Spartano

Beiser

et al. 2016

GERONA

135

151

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 75%

Section: Statistical Analysesmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

Tan

Spartano

Beiser

et al. 2016

GERONA

135

151

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“…There may even be an upper limit beyond which extensive physical activity may not yield any added benefit. A study examining physical activity and dementia did not find a significantly reduced risk for those participating in over 5 h per week of exercise (Chang et al 2010). Alternatively, the protective effect may be cumulative as higher levels of activity showed less cognitive decline in a study of women aged 70 years and older performing regular physical activity for 8 to 15 years (Weuve et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Changes in physical activity and cognitive decline in older adults living in the community

Lee

Kim

Han

et al. 2015

AGE

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Accumulating evidence suggests that physical activity may be beneficial in preserving cognition in late life. This study examined the association between baseline and changes in physical activity and cognitive decline in community-dwelling older people. Data were from the Korean Longitudinal Study of Aging, with 2605 aged 65 years and older subjects interviewed in 2006 and followed up for 2 years. Cognitive decline was defined by calculating the Reliable Change Index using the Mini-Mental State Examination. Physical activity levels were categorized as sedentary, low, or high. Changes in physical activity were classified as inactive, decreaser, increaser, or active. Logistic regression analysis of baseline and changes in physical activity with cognitive decline was performed. Compared with the sedentary group at baseline, both the low and high activity groups were less likely to experience cognitive decline. The active (odds ratio [OR]=0.40, 95 % confidence interval [CI] 0.23-0.68) and increaser (OR=0.45, 95 % CI 0.27-0.74) group, compared with the inactive counterpart, demonstrated a significantly lower likelihood of cognitive decline. Older adults who remained active or increased activity over time had a reduced risk of cognitive decline. Engagement in physical activity in late life may have cognitive health benefits.

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“…Case finding was based on a three-step procedure, previously described [10,11]. Dementia and MCI were diagnosed by a consensus conference following the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [12].…”

Section: Cognitive Status (Normal-mci-dementia)mentioning

confidence: 99%

Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study

et al. 2017

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Background/Objective: studies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life. Methods: we studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykjavik Study of whom 485 (9.4%) were diagnosed with mild cognitive impairment (MCI) and 307 (5.9%) with dementia. Visceral fat, abdominal and thigh subcutaneous fat, and thigh muscle were assessed by computed tomography. MCI and dementia were based on clinical assessment and a consensus meeting; those without MCI or dementia were categorised as normal. Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index (BMI). Results: among women, there was a decreased likelihood of dementia per SD increase in abdominal subcutaneous fat (OR 0.72; 95% CI: 0.59-0.88), thigh subcutaneous fat (0.81; 0.67-0.98) and thigh muscle (0.63; 0.52-0.76), but not visceral fat, adjusting for demographics, vascular risk factors, stroke and depression. Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI <25. In men, one SD increase in thigh muscle was associated with a decreased likelihood of dementia (0.75; 0.61-0.92). BC was not associated with MCI in men or women. Conclusion: a higher amount of abdominal and thigh subcutaneous fat were associated with a lower likelihood of dementia in women only, while more thigh muscle was associated with a lower likelihood of dementia in men and women.

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The Effect of Midlife Physical Activity on Cognitive Function Among Older Adults: AGES—Reykjavik Study

Abstract: Midlife PA may contribute to maintenance of cognitive function and may reduce or delay the risk of late-life dementia.

Cited by 158 publications

References 36 publications

Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

Changes in physical activity and cognitive decline in older adults living in the community

Associations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study

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