2010
DOI: 10.1016/j.brainres.2010.01.048
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The effect of MK-801 on motor activity and c-Fos protein expression in the brain of adolescent Wistar rats

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Cited by 12 publications
(3 citation statements)
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“…On the other hand, Wiley et al (2008) reported reduced stimulant effects of ketamine in adolescents, and Wilson et al (2007) reported negligible differences in ketamine-induced locomotor activity between adults and adolescents (both used a 10mg/kg dose). Consistent with our results and those of Parise et al (2013), Pesic and coworkers (2010), found that an acute dose of MK-801 (a highly potent and selective NMDA receptor antagonist), induced a greater increase in locomotor behavior in adolescents compared to adults. Differences in experimental approaches, including dose, time course of testing, habituation, animal strain, specific ages of the animals and other variables may be responsible for the differing results.…”
Section: Discussionsupporting
confidence: 92%
“…On the other hand, Wiley et al (2008) reported reduced stimulant effects of ketamine in adolescents, and Wilson et al (2007) reported negligible differences in ketamine-induced locomotor activity between adults and adolescents (both used a 10mg/kg dose). Consistent with our results and those of Parise et al (2013), Pesic and coworkers (2010), found that an acute dose of MK-801 (a highly potent and selective NMDA receptor antagonist), induced a greater increase in locomotor behavior in adolescents compared to adults. Differences in experimental approaches, including dose, time course of testing, habituation, animal strain, specific ages of the animals and other variables may be responsible for the differing results.…”
Section: Discussionsupporting
confidence: 92%
“…Drugs and dosage: Based on previous studies [ 1 , 28 ], a single administration of 0.1 mg/kg MK-801 was used to generate a schizophrenia-like animal model. The dosage schedules of haloperidol and CBS were converted by means of body surface area to conform to the human clinical schedule as described in the commercial product data sheet [ 29 , 30 , 39 ].…”
Section: Methodsmentioning
confidence: 99%
“…As we discussed previously (Pesić et al, 2010), locomotor activity and stereotypic behaviors are competing motor activities mediated by distinct mechanisms. The dopaminergic mesolimbic system has been directly implicated in the control of locomotor behavior, while the integrity of the dopaminergic input to the striatum (nigrostriatal system) probably plays a fundamental role in the control of stereotypic activity (Pijnenburg et al, 1976;Canales and Graybiel, 2000).…”
Section: The Influence Of Continuous Prenatal Exposure To Valproic Ac...mentioning
confidence: 74%