The Effect of Morphine Sulfate on Gastric Motility. Some Radiologic Observations in Man

Crone, RobertK; Ardran, G. M.

doi:10.1016/s0016-5085(57)80090-0

Cited by 16 publications

(1 citation statement)

References 7 publications

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“…, 1959 ;Burks and Long , 1967 ;Cairnie , Kosterlitz and Taylor, 1961). They also delay gastric emptying (Crone and Ardran, 1957 ;Nimmo et aI., 197 5b) and after pethidine (meperidine) or diamorphine (heroin) the process is not exponential. For example , the mean time to empty 50% of an ingested solution from the stomach was prolonged from 12 minutes in controls to 90 minutes after pethidine (150mg im) and to >130 minutes after diamorphine (10mg irn).…”

Section: Drugs Which Reduce Gastric Motilitymentioning

confidence: 99%

Drugs, Diseases and Altered Gastric Emptying

Nimmo¹

1976

Clinical Pharmacokinetics

199

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Drugs are usually given orally. They are not absorbed to any extent from the stomach but may be absorbed very rapidly from the small intestine. Thus factors influencing the rate of gastric emptying may alter the rate of absorption of most if not all orally administered drugs. Food, hormones, posture, peritoneal irritation, severe pain, gastric ulcer, diabetes and other metabolic diseases, as well as drugs such as alcohol, anticholinergics, narcotic analgesics, ganglion blocking drugs, antacids and metoclopramide all influence the rate of gastric emptying and they will, in turn, change the rate of absorption of another drug. In most instances, increasing the rate of gastric emptying and gastro-intestinal motility increases the rate of absorption of a drug but, for digoxin and riboflavin, increased gastrointestinal motility is associated with a decrease in the rate of absorption. Delayed drug absorption due to altered gastric emptying usually results in therapeutic failure, especially if the drug has a short biological half-life. At present it is not possible to predict accurately the magnitude and clinical relevance of all drug absorption interactions.

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Section: Drugs Which Reduce Gastric Motilitymentioning

confidence: 99%

Drugs, Diseases and Altered Gastric Emptying

Nimmo¹

1976

Clinical Pharmacokinetics

199

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The effects of analgesic drugs on gastro-intestinal motility in man

Neely

1969

Journal of British Surgery

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NEELY: GASTRO-INTESTINAL MOTILITY I N MAN925 histological examination demonstrated the presence of intravascular deposits in the afferent vessels. These deposit:, were not seen until 7-8 hours of perfusion in the first group of livers, while in the second group they occurred at 2-3 hours of perfusion and they were seen in a much greater number of vessels. It is concluded that the rise in the transhepatic resistance is due to the presence of these intravascular deposits. The nature and the origin of these deposits are discussed and possible methods of prevention are suggested.

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Oral controlled release dosage forms. A review

Haan

Lerk

1984

Pharmaceutisch Weekblad Scientific Edition

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When a drug meets the criteria which make incorporation into a controlled release dosage form rational, a proper dosage form has to be selected. Oral controlled release products, available on the Dutch market, are referred to in discussing the various methods used to control drug release by galenical means in order to achieve a prolonged therapeutic effect. The effects of some physiological variables of the alimentary tract on drug delivery from the various dosage forms, especially with regard to formulation and design, are reviewed.

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The Effect of Morphine Sulfate on Gastric Motility. Some Radiologic Observations in Man

Cited by 16 publications

References 7 publications

Drugs, Diseases and Altered Gastric Emptying

Drugs, Diseases and Altered Gastric Emptying

The effects of analgesic drugs on gastro-intestinal motility in man

Oral controlled release dosage forms. A review

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