One of the initiatives to strengthen the Indonesian economy is entrepreneurship. Concern has been raised about how little entrepreneurship is being pursued by recent college graduates. Several earlier studies have discovered that an entrepreneur can successfully run his business if there is an interest in entrepreneurship. Therefore, the purpose of this study was to investigate how entrepreneurship education, entrepreneurship intentions, and entrepreneurship motivation affect students’ entrepreneurship interest in entrepreneurship among higher education students in Bandar Lampung, Indonesia. Regarding the geopolitical constellations at the international, national, and regional levels, Bandar Lampung, Indonesia, is in a very favorable position. Thus, 180 students who had taken entrepreneurship courses at nine universities in Bandar Lampung were asked to complete a questionnaire, and the information was then analyzed using PLS-SEM. It was determined that entrepreneurship education had no discernible impact on entrepreneurship motivation. Furthermore, entrepreneurship interest was not significantly impacted by entrepreneurship motivation. Additionally, there was no discernible mediating effect of entrepreneurial motivation on entrepreneurial education to entrepreneurship interest. However, the relationship between entrepreneurship motivation and entrepreneurship education was significantly impacted by entrepreneurship intention. These results imply that students at the university in Bandar Lampung believe that entrepreneurship education is like other lectures and do not develop an interest in entrepreneurship.