The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy – A Pooled Analysis of Two Randomized Controlled Trials

Brok, Melina G.H.E. den; Hoevenaar‐Blom, Marieke P.; Coley, Nicola; Andrieu, Sandrine; Dalen, Jan Willem van; Meiller, Yannick; Guillemont, Juliette; Brayne, Carol; Gool, Willem A. van; Charante, Eric P. Moll van; Richard, Edo

doi:10.14283/jpad.2021.53

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…Importantly, this study highlights barriers that hinder the uptake of multidomain interventions: lack of knowledge about potential benefits, lack of support networks, and (perceived) financial costs, which were particularly hindering participation of those with higher dementia risk. This stands in contrast to findings from a pooled analysis of MAPT and preDIV data, that, despite not providing conclusive evidence that multidomain interventions reduce risk of cognitive decline, suggested these interventions may be more effective in those with lower cognitive functioning [35].…”

Section: Barriers Facilitators and Adherence To Multidomain Intervent...contrasting

confidence: 99%

Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments

Röhr

Kivipelto

Mangialasche

et al. 2022

Current Opinion in Psychiatry

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Purpose of reviewThe potential for dementia prevention is deemed substantial if modifiable risk factors were addressed. First large-scale multidomain lifestyle interventions aiming at reducing risk of cognitive decline and dementia have yielded mixed but promising evidence. Recent findingsDespite the impact of the COVID-19 pandemic on trials conduction, causing interruptions and delays, the research landscape on multidomain interventions is growing rapidly. The successful Finish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) has led to an adaptation of the FINGER model in trials underway or being planned in over 40 countries. Recent studies identified barriers and facilitators of and adherence to multidomain interventions, showed the suitability of dementia risk scores as surrogate outcomes, and suggested mechanisms. Multidomain interventions are increasingly conducted in the Global South, and study protocols are increasingly testing expanded FINGER models, for example, with pharmacological components, in digital/remote settings and co-designed personalized interventions.

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Section: Barriers Facilitators and Adherence To Multidomain Intervent...contrasting

confidence: 99%

Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments

Röhr

Kivipelto

Mangialasche

et al. 2022

Current Opinion in Psychiatry

View full text Add to dashboard Cite

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“…A pooled analysis of 2 multidomain intervention trials focused on cardiovascular and lifestyle strategies (MAPT and PreDIVA; N=4162 participants; median age, 74 years) found no significant overall association between multidomain prevention and cognitive decline. 166 Cognitive benefits were observed among participants with lower baseline cognitive function (MMSE score <26; n=250; mean difference in change, 0.84 [95% CI, 0.15–1.54]; P <0.001]).…”

Section: Brain Healthmentioning

confidence: 98%

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2023

Circulation

3,560

702

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BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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“…A pooled analysis of 2 multidomain intervention trials focused on cardiovascular and lifestyle strategies (MAPT and PreDIVA; N=4162 participants; median age, 74 years) found no significant overall association between multidomain prevention and cognitive decline. 205 Cognitive benefits were observed among participants with lower baseline cognitive function (MMSE score <26; n=250; mean difference in change, 0.84 [95% CI, 0.15–1.54]; P <0.001]).…”

Section: Brain Healthmentioning

confidence: 98%

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Martin,

Aday,

Almarzooq

et al. 2024

Circulation

458

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BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year’s worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy – A Pooled Analysis of Two Randomized Controlled Trials

Cited by 6 publications

References 37 publications

Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments

Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

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