The effect of multivitamin supplements on continuation rate and side effects of combined oral contraceptives: A randomised controlled trial

Abstract

Multivitamin supplements could significantly reduce the side effects of COCs in the initial cycles and improve continuation rates. However, the study limitations do not allow for any definite conclusion for their use in clinical practice, especially in communities rich in nutrients.

Vitamin D in the Middle East and North Africa

“…The search yielded 1280 citations after removal of duplicates. We screened the full text of 242 papers, and identified 14 relevant trials ( Shahgheibi et al, 2016 ; Vaziri et al, 2016 ; Saad et al, 2018 ; Talaat et al, 2016 ; Taheri et al, 2015 ; Tepper et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ; Mohammad-Alizadeh-Charandabi et al, 2015 ; Shehata, 2016 ; Rahme et al, 2017 ; Mojibian et al, 2015 ; Behjat Sasan et al, 2017 ).…”

“…The current update identified 8 trials: 5 from Iran ( Taheri et al, 2015 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ; Mohammad-Alizadeh-Charandabi et al, 2015 ), 1 from Egypt ( Shehata, 2016 ), one from occupied Palestine/Israel ( Tepper et al, 2016 ), and one from Lebanon ( El-Hajj Fuleihan et al, 2016 ; Rahme et al, 2017 ). The latter was included in our previous review ( Chakhtoura et al, 2017a ), since we had access to primary data, but it was not published then, and is described herein ( Table 1 ) ( El-Hajj Fuleihan et al, 2016 ; Taheri et al, 2015 ; Tepper et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ).…”

“…The latter was included in our previous review ( Chakhtoura et al, 2017a ), since we had access to primary data, but it was not published then, and is described herein ( Table 1 ) ( El-Hajj Fuleihan et al, 2016 ; Taheri et al, 2015 ; Tepper et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ). The risk of bias in the included trials was unclear ( Taheri et al, 2015 ; Tepper et al, 2016 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ) to high ( Zarrin et al, 2017 ; Mohammad-Alizadeh-Charandabi et al, 2015 ), with the exception of 2 RCTs considered at low risk of bias ( El-Hajj Fuleihan et al, 2016 ; Shehata, 2016 ). Three studies were conducted exclusively in women ( Taheri et al, 2015 ; Mohammad-Alizadeh-Charandabi et al, 2015 ; Shehata, 2016 ), one study exclusively in men ( Tepper et al, 2016 ) and the others included both genders ( El-Hajj Fuleihan et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ).…”

“…The risk of bias in the included trials was unclear ( Taheri et al, 2015 ; Tepper et al, 2016 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ) to high ( Zarrin et al, 2017 ; Mohammad-Alizadeh-Charandabi et al, 2015 ), with the exception of 2 RCTs considered at low risk of bias ( El-Hajj Fuleihan et al, 2016 ; Shehata, 2016 ). Three studies were conducted exclusively in women ( Taheri et al, 2015 ; Mohammad-Alizadeh-Charandabi et al, 2015 ; Shehata, 2016 ), one study exclusively in men ( Tepper et al, 2016 ) and the others included both genders ( El-Hajj Fuleihan et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ; Jozanikohan and Kazemi Saleh, 2015 ). The mean BMI was ≥25 kg/m 2 in all studies ( El-Hajj Fuleihan et al, 2016 ; Taheri et al, 2015 ; Tepper et al, 2016 ; Zarrin et al, 2017 ; Kamelian et al, 2017 ; Shehata, 2016 ).…”

Impact of magnesium deficiency on the quality of life of women using hormonal contraception

“…С другой стороны, в исследовании S. Mohammad-Alizadeh-Charandabi et al было показано, что частота прекращения приема ГК в связи с побочными эффектами значительно ниже при дополнительном приеме витаминно-минеральных ком-плексов: по сравнению с плацебо -в 2 раза (ОР = 2,26; 95% ДИ: 1,15-4,45) и с отсутствием добавок -в 3 раза (ОР = 3,15; 95% ДИ: 1,66-5,99) [34].…”