The Effect of Myricetin on Pharmacokinetics of Atomoxetine and its Metabolite 4-Hydroxyatomoxetine In Vivo and In Vitro

Abstract

Our study showed that myricetin could significantly inhibit the formation of atomoxetine metabolite both in vivo and in vitro. It is recommended that the effect of myricetin on the metabolism of atomoxetine should be noted and atomoxetine plasma concentration should be monitored.

Study on consequences for interaction of myricetin with canagliflozin: A special attention to pharmacokinetics and pharmacodynamics of drug

“…It is a member of the flavonoid class polyphenolic compounds. It shows antidiabetic activity and inhibits the activity of CYP 2C8, CYP 2C9 and CYP 3A4 enzymes 3 . Till now, research has been done to study the interaction of Myricetin individually with drugs like atomoxetin, docetaxel, carvedilol, tamoxifen and losartan [3][4][5][6][7] .…”

“…It shows antidiabetic activity and inhibits the activity of CYP 2C8, CYP 2C9 and CYP 3A4 enzymes 3 . Till now, research has been done to study the interaction of Myricetin individually with drugs like atomoxetin, docetaxel, carvedilol, tamoxifen and losartan [3][4][5][6][7] . Canagliflozin [2S,3R,4R,5S,6R)-2-{3-[5-[4-fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyltetrahydropyran-3,4,5-triol] is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).…”