The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Abstract

Objective: Taxane-induced nail changes are considered as an important cosmetic manifestation with an incidence that reaches up to 44% of patients treated with taxane-included therapeutic regimens. In this article, we represent a clinical observational study to evaluate the effect of cosmetic nail lacquer on taxane-induced nail changes in female patients diagnosed with breast cancer. Methods: Prospectively, we identified those women who were diagnosed with breast cancer, scheduled to have AC-Taxol protocol. Any female with previous dermatological or systemic disorders that affect nails was excluded from the study. Patients were categorized into 2 groups based on the utilization of nail lacquer. The first group includes women who started to use the nail lacquer after development of nail changes. The second group comprises those women who did not use the nail lacquer at any occasion. Results: A total of 59 female patients were included in the study; 46 (78%) of them developed nail changes and the main change was nail discoloration. The first group which has used nail lacquer (17, 28.8%) showed an improvement among 15 (78.9%) patients, whereas 2 (7.4%) of them continued to have worsening symptoms. On the contrary, most of the second group (25, 92.9%) did not show any improvement in nail changes. A statistical significance between the tested groups was observed ( P = .000). There is no statistical association between the progression of nail changes and the age of patients. Conclusions: Taxane-induced nail changes are considered as an important clinical, cosmetic, and psychological complication, especially for female patients with cancer. This article suggests that nail lacquer may have an effect in the improvement of nail changes, especially nail discoloration. Further investigations are recommended to prove the efficacy of nail lacquer.

The Efficacy of Chemo-Cooling Gloves in Preventing Nail Toxicity among Thai Women Undergoing Chemotherapy: A Quasi-experimental Study

“…Variability in chemotherapy regimens across studies emphasizes the impact of specific drugs on nail toxicity. Alshari et al 11 investigated using nail lacquer to mitigate taxane-induced nail changes and demonstrated its effectiveness. While nail lacquer offers a non-invasive protective measure, it requires regular application, which may not be convenient for all patients.…”

“…Such pain and discomfort substantially diminish patients' quality of life, often impeding their ability to perform daily functions. 3,11 Therefore, effective management of chemotherapyinduced nail toxicity is essential to minimize adverse complications and enhance patients' quality of life. 12 Hence, this study was conducted in Thailand among women undergoing chemotherapy.…”

Factores relacionados con la calidad de vida, la depresión, la ansiedad, la imagen corporal y la autoestima, en mujeres mastectomizadas supervivientes de cáncer de mama

“…El 44% de las supervivientes sufre una decoloración en las uñas y problemas con las mismas, tanto en las manos como en los pies, en la mayoría de los casos estos inconvenientes ungueales suelen desaparecer tras la finalización del tratamiento, pero durante el mismo pueden provocar lesiones dolorosas que pueden afectar a diversas funciones, que van desde hematomas hasta la separación del lecho ungueal llamado onicólisis, no existe ningún tratamiento para la mejora de estas manifestaciones aunque el lavado de las mismas y el no uso de sustancias tóxicas como productos de limpieza o pinta uñas son las mejores estrategias de prevención [77].…”