The effect of neoadjuvant chemotherapy and chemoradiotherapy on exercise capacity and outcome following upper gastrointestinal cancer surgery: an observational cohort study

West, Malcolm; Loughney, Lisa; Ambler, Gareth; Dimitrov, Borislav D.; Kelly, Jamie; Mythen, Michael G.; Sturgess, Richard; Calverley, PM; Kendrick, Adrian; Grocott, Michael P.W.; Jack, Sandy

doi:10.1186/s12885-016-2682-6

Cited by 11 publications

(11 citation statements)

References 18 publications

(16 reference statements)

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“…The increased rate of ADC values at 6 months after CRT treatment was negatively correlated with tumor volumes before and 6 months after CRT treatment, while positively correlated with tumor regression rate at 6 months after CRT treatment. It is well known that CRT is commonly applied to treat human cancers, 12–14 which leads to tumor cell death and apoptosis, and is correlated with ADC value increase 15. The increases of ADC values were observed in non-small-cell lung cancer during CRT 16.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

Ju¹

2016

OTT

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ObjectiveThis study aims to evaluate the efficacy of chemoradiotherapy (CRT) in cervical cancer using diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values.MethodsA total of 71 patients with cervical cancer were enrolled in this study. All patients underwent conventional magnetic resonance imaging and DWI scanning before CRT and at 7, 14, 21 days, and 6 months after CRT. These patients were divided into the complete response (CR) and non-CR groups according to the response evaluation criteria in solid tumors criteria. Receiver operating characteristic (ROC) curve was used to evaluate the accuracy of ADC values in predicting the efficacy of CRT in cervical cancer.ResultsCompared with before-CRT treatment, tumor volumes were reduced and ADC values were elevated in both CR and non-CR groups after CRT treatment. At 21 days after CRT, tumor volumes in the CR group were smaller than those in the non-CR group. During the period of 21 days to 6 months after CRT, tumor regression rate and the increased rate of ADC values in the CR group were higher than those in the non-CR group. ROC curves revealed that the increased rate of ADC values at 21 days after CRT was the optimal time point for the prediction of CRT efficacy in cervical cancer, with the area under the curve, sensitivity, and specificity of 0.775, 92.7%, and 62.5%, respectively.ConclusionOur study provides evidence that the increased rate of ADC at 21 days after CRT might be a promising tool for predicting the efficacy of CRT in cervical cancer.

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Section: Discussionmentioning

confidence: 93%

Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

Ju¹

2016

OTT

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“…Therefore, to maximum surgery outcome and improve prognosis, neoadjuvant chemotherapy has been adopted widely resulting in increased tumorectomy succeed and enhanced treatment outcomes. [5][6][7][8] However, the effectiveness of current chemotherapies in patients with GC remains unpredictable including neoadjuvant chemotherapy. If biomarkers are available for predicting outcomes and adverse effects of neoadjuvant chemotherapy, the treatment ratio for advanced GC may be able to improve.…”

Section: Introductionmentioning

confidence: 99%

Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer

Tan

Yong

Duan³

et al. 2017

Clinical Laboratory Analysis

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“…This prospective study involved participants with OG cancers scheduled for chemo/chemoradiotherapy followed by elective resection with curative intent. The study protocol, methods and statistical analysis plan are available in open access format 14 . This study was funded by the National Institute for Health (NIHR), Research for Patient Benefit Programme (PB-PG-0609-18262).…”

Section: Methodsmentioning

confidence: 99%

“…Similar interrogations were undertaken for mortality at 5-years after surgery. Risk categories were defined a priori 14 .…”

Section: Methodsmentioning

confidence: 99%

The effects of cancer therapies on physical fitness before oesophagogastric cancer surgery: a prospective, blinded, multi-centre, observational, cohort study

et al. 2021

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Background: Neoadjuvant cancer treatment is associated with improved survival following major oesophagogastric cancer surgery. The impact of neoadjuvant chemo/chemoradiotherapy on physical fitness and operative outcomes is however unclear. This study aims to investigate the impact of neoadjuvant chemo/chemoradiotherapy on fitness and post-operative mortality. Methods: Patients with oesophagogastric cancer scheduled for chemo/chemoradiotherapy and surgery were recruited to a prospective, blinded, multi-centre, observational cohort study. Primary outcomes were changes in fitness with chemo/chemoradiotherapy, measured using cardiopulmonary exercise testing and its association with mortality one-year after surgery. Patients were followed up for re-admission at 30-days, in-hospital morbidity and quality of life (exploratory outcomes). Results: In total, 384 patients were screened, 217 met the inclusion criteria, 160 consented and 159 were included (72% male, mean age 65 years). A total of 132 patients (83%) underwent chemo/chemoradiotherapy, 109 (71%) underwent chemo/chemoradiotherapy and two exercise tests, 100 (63%) completed surgery and follow-up. A significant decline in oxygen uptake at anaerobic threshold and oxygen uptake peak was observed following chemo/chemoradiotherapy: -1.25ml.kg-1.min-1 (-1.80 to -0.69) and -3.02ml.kg-1.min-1 (-3.85 to -2.20); p<0.0001). Baseline chemo/chemoradiotherapy anaerobic threshold and peak were associated with one-year mortality (HR=0.72, 95%CI 0.59 to 0.88; p=0.001 and HR=0.85, 0.76 to 0.95; p=0.005). The change in physical fitness was not associated with one-year mortality. Conclusion: Chemo/chemoradiotherapy prior to oesophagogastric cancer surgery reduced physical fitness. Lower baseline fitness was associated with reduced overall survival at one-year. Careful consideration of fitness prior to chemo/chemoradiotherapy and surgery is urgently needed.

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The effect of neoadjuvant chemotherapy and chemoradiotherapy on exercise capacity and outcome following upper gastrointestinal cancer surgery: an observational cohort study

Cited by 11 publications

References 18 publications

Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

Evaluation of the efficacy of chemoradiotherapy in cervical cancer using diffusion-weighted imaging and apparent diffusion coefficient

Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer

The effects of cancer therapies on physical fitness before oesophagogastric cancer surgery: a prospective, blinded, multi-centre, observational, cohort study

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