The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRF1 /CRF2 and H1/ H3 receptors

Heidarzadeh, Hooman; Zendehdel, Morteza; Babapour, Vahab; Gilanpour, H

doi:10.1007/s11259-017-9706-9

Cited by 25 publications

(11 citation statements)

References 38 publications

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“…When nesfatin-1 was injected ICV in rats, its anorexigenic effect was abolished by pretreatment with the selective corticotropin-releasing factor (CRF) 2 antagonist astressin 2 -B [ 24 ] indicating downstream mediation via corticotropin-releasing factor receptor 2 (CRF 2 ) signaling. This finding was also confirmed in chicks with astressin-B, a CRF 1/2 antagonist [ 35 ]. Because the melanocortin receptor 3/4 antagonist SHU9119, with anorexigenic melanocortin 4 signaling being well established upstream of CRF [ 36 , 37 ], attenuated [ 34 ] or blocked [ 1 ] nesfatin-1’s anorexigenic effect, nesfatin-1 might act via melanocortin → CRF signaling to inhibit food intake.…”

Section: Implications Of Nesfatin-1 In the Regulation Of Food Intasupporting

confidence: 54%

Current Understanding of the Role of Nesfatin-1

Schalla

Stengel

2018

Journal of the Endocrine Society

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Nesfatin-1 was discovered in 2006 and implicated in the regulation of food intake. Subsequently, its widespread central and peripheral distribution gave rise to additional effects. Indeed, a multitude of actions were described, including modulation of gastrointestinal functions, glucose and lipid metabolism, thermogenesis, mediation of anxiety and depression, as well as cardiovascular and reproductive functions. Recent years have witnessed a great increase in our knowledge of these effects and their underlying mechanisms, which will be discussed in the present review. Lastly, gaps in knowledge will be highlighted to foster further studies.

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Section: Implications Of Nesfatin-1 In the Regulation Of Food Intasupporting

confidence: 54%

Current Understanding of the Role of Nesfatin-1

Schalla

Stengel

2018

Journal of the Endocrine Society

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“…Our food intake experiment demonstrated that nesfatin-1 ICV treatment leads to a significant reduction in food intake levels in rainbow trout 6 and 24 h post-injection, in agreement with previous observations in other fish species [goldfish, (35, 36)], birds [chicks, (59)] and mammals [mice, (32, 60); rats, (26, 61)]. The upregulation of pomca1 and cart mRNA expression in the trout brain, but the lack of effects on npy and agrp levels, suggests that the observed anorexigenic effect of nesfatin-1 in rainbow trout is mediated by the enhancement of potent brain appetite-inhibitors rather than by the suppression of central signals stimulating appetite.…”

Section: Discussionsupporting

confidence: 92%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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Nesfatin-1 is an 82 amino acid peptide that has been involved in a wide variety of physiological functions in both mammals and fish. This study aimed to elucidate the role of nesfatin-1 on rainbow trout food intake, and its putative effects on glucose and fatty acid sensing systems. Intracerebroventricular administration of 25 ng/g nesfatin-1 resulted in a significant inhibition of appetite, likely mediated by the activation of central POMC and CART. Nesfatin-1 stimulated the glucosensing machinery (changes in sglt1, g6pase, gsase, and gnat3 mRNA expression) in the hindbrain and hypothalamus. Central fatty acid sensing mechanisms were unaltered by nesfatin-1, but this peptide altered the expression of mRNAs encoding factors regulating lipid metabolism (fat/cd36, acly, mcd, fas, lpl, pparα, and pparγ), suggesting that nesfatin-1 promotes lipid accumulation in neurons. In the liver, intracerebroventricular nesfatin-1 treatment resulted in decreased capacity for glucose use and lipogenesis, and increased the potential of fatty acid oxidation. Altogether, the present results demonstrate that nesfatin-1 is involved in the homeostatic regulation of food intake and metabolism in fish.

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“…Food consumption was calculated as a gram of body weight (g/100g BW) to minimize the impact of body weight on the amount of feed intake. These doses of drugs were determined according to the pilot and previous studies (Zeni et al, 2000;Baghbanzadeh & Babapour, 2007;Zendehdel et al, 2009;Ahmadi et al, 2017;Heidarzadeh et al, 2017).…”

Section: Feeding Experimentsmentioning

confidence: 99%

“…Also, Finelli et al, (2014) reported ICV injection of the Astressin2-B decreased feed intake in rats (Finelli et al, 2014). Recently, Heidarzadeh et al, (2017) reported ICV injection of the Astressin-B affects nesfatin-1 induced hypophagia in FD 3 broiler chicken.…”

Section: Introductionmentioning

confidence: 99%

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

Ahmadi

Zendehdel

Babapour

et al. 2019

Braz. J. Poult. Sci.

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Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited. So, the aim of the current study was to determine interaction of the glutamate with melanocortin and corticotropin systems on food intake in 3-h food-deprived (FD 3 ) neonatal meat-type chicken. In experiment 1, chicken intracerebroventricular (ICV) injected (A) phosphate-buffered saline (PBS), (B) glutamate (75 nmol), (C) glutamate (150 nmol) and (D) glutamate (300 nmol). In experiment 2, (A) PBS, (B) astressin-B (CRF 1 /CRF 2 receptors antagonist, 30 µg), (C) glutamate (300 nmol) and (D) astressin-B+glutamate were ICV injected. Experiments 3-5 were similar to experiment 2, except birds were injected with astressin2-B (CRF 2 receptor antagonist, 30 µg), SHU9119 (MC 3 /MC 4 receptor antagonist, 0.5 nmol) and MCL0020 (MC 4 receptor antagonist, 0.5 nmol) instead of the astressin-B. In experiment 6, the injections were (A) PBS, (B) MTII (MC 3 /MC 4 receptor agonist, 2.5ng), (C) glutamate (75nmol) and (D) MTII+glutamate. Then, cumulative feed intake was recorded at 30, 60 and 120 minutes after injection. According to the results, dose dependent hypophagia observed by ICV injection of the glutamate (75, 150 and 300nmol) compared to control group in neonatal broiler chicken (p<0.05). Co-injection of the astressin-B+glutamate and astressin2-B+glutamate decreased glutamateinduced hypophagia in neonatal broiler chicken (p<0.05). Coinjection of the glutamate+MC 3 /MC 4 receptors antagonist decreased hypophagic effect of the glutamate (p<0.05). These results suggested hypophagic effect of the glutamate mediates via CRF 1 /CRF 2 and MC 3 / MC 4 receptors in chickens.

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The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRF1 /CRF2 and H1/ H3 receptors

Cited by 25 publications

References 38 publications

Current Understanding of the Role of Nesfatin-1

Current Understanding of the Role of Nesfatin-1

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

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