The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

Hakozaki, Tomohiro; Minwalla, Ljiljana; Zhuang, Jinfu; Chhoa, M.; Matsubara, Atsushi; Miyamoto, Kukizo; Greatens, Amanda; Hillebrand, Greg G.; Bissett, Donald; Boissy, Raymond E.

doi:10.1046/j.1365-2133.2002.04834.x

Cited by 367 publications

(301 citation statements)

References 18 publications

(25 reference statements)

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“…In vitro, centaureidin [99], a flavone from Achillea millefolium (common yarrow), and methylophiopogonanone B [100] (MOPB), a homoisoflavonoid from Ophiopogon japonicus (mondo grass), block melanosome transfer by inducing the retraction of melanocyte dendrites through activation of GTPase Rho (the master regulator of dendrite formation in melanocytes) [101]). Niacinamide (the amide form of vitamin B3), inhibits melanosome transfer in vitro and has a significant effect in reducing hyperpigmentation in vivo, although its mode of action is not known [102]. Another in vitro study showed that plasma membrane lectins and their glycoconjugates interfere with melanocyte-keratinocyte interactions by binding to their specific plasma membrane receptors and inhibiting melanosome transfer [103].…”

Section: Biological Effectorsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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Rates of skin cancer continue to increase despite the improved use of traditional sunscreens to minimize damage from ultraviolet radiation. The public perception of tanned skin as being healthy and desirable, combined with the rising demand for treatments to repair irregular skin pigmentation and the desire to increase or decrease constitutive skin pigmentation, arouses great interest pharmaceutically as well as cosmeceutically. This review discusses the intrinsic biochemistry of pigmentation, details mechanisms that lead to increased or decreased skin pigmentation, and summarizes established and potential hyper-and hypo-pigmenting agents and their modes of action.

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Section: Biological Effectorsmentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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“…Niacinamide was found to decrease hyperpigmentation compared with placebo alone after 4 weeks of use in a study to assess the melanogenesis in vitro and facial hyperpigmentation and skin colour in vivo in Japanese women. 18 Considering the beneficial effects of these botanicals, the objective of the study was to assess the effectiveness of the study medication containing a combination of niacinamide 4.0%, glycolic acid 2.0%, vitamin E acetate 0.1%, kojic acid dipalmitate 2.0%, soy isoflavones 0.5%, arbutin 2.0%, pterowhite 0.12%, licorice 40% CA 0.12% and ascorbyl glucoside 0.1% in the treatment of epidermal pigmentation.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of a novel topical depigmenting agent in epidermal pigmentation: an open-label, non-comparative study

2018

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Background: Active compounds isolated from plants are known to inhibit melanogenesis without melanocytotoxicity. The aim of this study was to assess the effectiveness and safety of a cream containing a combination of niacinamide, glycolic acid, vitamin E acetate, kojic acid, soy isoflavones, arbutin, pterowhite, licorice and ascorbyl glucoside for the treatment of epidermal pigmentation.Methods: Sixty subjects (between 18-45 years) with epidermal pigmentation were enrolled in this 12-week, open-label, non-comparative study. Clinical/dermoscopic aspects (grade-1: <25%; grade-2: 25-50%; grade-3: 50-75%; grade-4: >75% reduction in the amount of epidermal pigment); melanin index/erythema measure (Dermacatch); extent, depth and density of pigmentation (FotoFinder) and safety were assessed.Results: Out of 60 enrolled subjects, 53 completed the study. Overall percentage of melanin and erythema improvement (Dermacatch) was 24.2% and 7.4% respectively (p<0.05). Based on Fotofinder images, 13% had grade 4 improvement, 47% had grade 3 improvement, 30% had grade 2 improvement while 9% subjects had grade 1 improvement. On the basis of clinical photographic images, 15% had grade 4 improvements in the skin colour, 41% had grade 3, 34% had grade 2 and 9% subjects had grade 1 improvement. Adverse effect of skin irritation was reported in one subject, which resolved after discontinuing the treatment.Conclusions: Cream containing a combination of niacinamide 4.0%, glycolic acid 2.0%, vitamin E acetate 0.1%, kojic acid dipalmitate 2.0%, soy isoflavones 0.5%, arbutin 2.0%, pterowhite 0.12%, licorice 40% CA 0.12%, ascorbyl glucoside 0.1% was found to be safe and effective in the treatment of epidermal pigmentation.

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“…One can assume that antioxidants, particularly ascorbic acid [18] [20], niacinamide [21] and GSH [22] have skin whitening properties. Niacinamide is a well-known vitamin that decreases melanosome transfer [23] with a very interesting light effect [24]. As for ascorbic acid, it interacts with copper ion at the tyrosinase activity site with strong antioxidant properties [25] and anti-inflammatory effects [20] (Figure 6 and Figure 7).…”

Section: Discussionmentioning

confidence: 99%

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

Grand-Vincent¹,

Boisnic²,

Salomon³

et al. 2017

JCDSA

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Mesotherapy is a mildly invasive procedure involving several subcutaneous drug injections, which are performed simultaneously. The concept is to inject a very small amount of active compounds (hyaluronic acid, vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the biosynthetic capacity of fibroblasts, increase collagen and elastin production and to give active essential molecules for a fibroblasts environment. Numerous studies suggest that the mesotherapy procedure improves skin hydration and mechanical properties; however, some results have not been statistically significant. In this study, we investigated an antiaging treatment as a complementary approach to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our main objective was to assess the improvement of face, neck and neckline skin quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories, includes a non-cross-linked hyaluronic acid, vitamins, antioxidants, mineral salts and enzymes. A statistically significant decrease in the depth of crow's-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also, dermatological scores showed a significant decrease, and data suggest that skin tone was improved with a brighter tone. The injected mixture could then have an action on the skin pigmentation process with a photoprotective effect. Evolution of Dermis density was also investigated and an increase of dermal density and thickness were highlighted, showing an improvement of skin firmness with significant increases of dermis thickness (20%) and dermis density (24%), indicating a neocollagen activity.

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The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

Abstract: The data suggest niacinamide is an effective skin lightening compound that works by inhibiting melanosome transfer from melanocytes to keratinocytes.

Cited by 367 publications

References 18 publications

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Effectiveness and safety of a novel topical depigmenting agent in epidermal pigmentation: an open-label, non-comparative study

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

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