The effect of Nigella sativa on non-alcoholic fatty liver disease: A systematic review and meta-analysis

Tiwari, Anoop; Surendra, G.; Meka, Soumya; Varghese, Bincy; Vishwakarma, Gayatri; Adela, Ramu

doi:10.1016/j.hnm.2022.200146

Cited by 4 publications

(14 citation statements)

References 42 publications

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“…All meta-analyses were published in peer-reviewed journals between 2016 and 2022. These studies were conducted in seven regions: 13 from Iran ( 28 , 30 , 33 , 34 , 37 – 45 ), two from China ( 32 , 35 ), and one each from Australia ( 26 ), India ( 27 ), United Kingdom ( 29 ), the USA ( 31 ), and Indonesia ( 36 ). The number of RCTs ranged from three to 50, with 187–3,679 subjects.…”

Section: Resultsmentioning

confidence: 99%

“…The treatment duration ranged from 2 weeks to 1 year. Four studies registered protocols on the PROSER platform ( 27 – 29 , 39 ) and one in the Cochrane library ( 31 ). In terms of the risk of bias tools, 10 studies used the Cochrane risk of bias tool ( 26 – 28 , 30 , 31 , 33 , 35 , 39 , 44 , 45 ), nine studies used the Jadad scale ( 32 , 34 , 36 – 38 , 40 – 43 ), and one used the standardized JBI critical appraisal checklist ( 29 ).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies evaluated the effects of N. sativa on lipid profiles ( 26 , 27 , 29 , 31 , 35 , 37 , 43 , 45 ). Six studies found that N. sativa reduced total cholesterol (TC) in patients with metabolic disorders ( 26 , 29 , 31 , 37 , 43 , 45 ), but one study showed that N. sativa had no effect on patients with non-alcoholic fatty liver disease (NAFLD) ( 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies found that N. sativa reduced total cholesterol (TC) in patients with metabolic disorders ( 26 , 29 , 31 , 37 , 43 , 45 ), but one study showed that N. sativa had no effect on patients with non-alcoholic fatty liver disease (NAFLD) ( 35 ). Seven studies found that N. sativa significantly reduced triglyceride (TG) levels ( 27 , 29 , 31 , 37 , 45 ), although four studies revealed that it did not change TG levels ( 26 , 31 , 35 , 43 ). Six studies found that N. sativa reduced low-density lipoprotein cholesterol (LDL-C) levels ( 26 , 27 , 29 , 37 , 43 , 45 ), drawing consistent conclusions.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies found that N. sativa significantly reduced triglyceride (TG) levels ( 27 , 29 , 31 , 37 , 45 ), although four studies revealed that it did not change TG levels ( 26 , 31 , 35 , 43 ). Six studies found that N. sativa reduced low-density lipoprotein cholesterol (LDL-C) levels ( 26 , 27 , 29 , 37 , 43 , 45 ), drawing consistent conclusions. Only one study showed a significant effect on high-density lipoprotein cholesterol (HDL-C) levels ( 27 ), whereas the remaining five studies found that N. sativa did not change HDL-C levels ( 26 , 29 , 31 , 43 , 45 ).…”

Section: Resultsmentioning

confidence: 99%

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Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

Wang

et al. 2023

Front. Nutr.

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BackgroundNigella sativa (N. sativa) consumption has been associated with various health outcomes; however, the results are not completely consistent.ObjectivesThis overview of systematic reviews and meta-analyses aimed to evaluate the reporting and methodological quality, and to grade the available evidence of associations between N. sativa and health outcomes.MethodsPubMed, Cochrane Library, Embase, and Scopus databases were searched from their inception to September 30, 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 statement, Assessment of Multiple Systematic Reviews (AMSTAR) 2 checklist, and Grades of Recommendations, Assessment, Development and Evaluations (GRADE) systems were used to assess the reporting, methodological, and evidence quality for each meta-analysis, respectively. The results were synthesized in a narrative form.ResultsThis overview included 20 eligible meta-analyses published in peer-reviewed journals between 2013 and 2021. The overall methodological quality was relatively poor, with only one moderate quality, four low quality, and 15 critically low quality studies. For reporting quality, items two, five, eight, nine, 15, and 24 need to improve. Among the 110 outcome indicators of the quality of evidence, five were graded as moderate, 17 as low, and 88 as very low. Risk of bias, inconsistency, and imprecision were the main downgrading factors.ConclusionThis overview suggests that N. sativa is beneficial for various clinical outcomes. However, there are certain limitations to reporting and methodological quality. The clinical efficacy of N. sativa requires confirmation in high-quality, large-sample, randomized controlled trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

Wang

et al. 2023

Front. Nutr.

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Black Seeds

Singletary¹

2022

Nutr Today

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Black seeds, sometimes called black cumin, are obtained from the spicy medicinal herb Nigella sativa that is native to a broad region encompassing the eastern Mediterranean, southwest Asia, and northern Africa. The seed and its oil have a distinctive aroma and taste, diversely described as bitter, peppery, metallic, and pungent. Both are frequent ingredients in numerous foods, especially in the Middle East and India. In these same regions N sativa has an extensive history as a folk medicine dating back millenia for relief for a variety of health conditions such as asthma, headache, bronchitis, amenorrhea, allergies, infections, and hypertension. The antioxidant, anti-inflammatory, and immunomodulatory properties of N sativa seeds observed in preclinical studies provided an impetus for clinical trials examining the seeds' effects on cardiovascular, respiratory, and neurological disorders, among others. This narrative review summarizes findings from publications addressing several these and other disorders and provides suggestions for future research.

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The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

j. info kesehat.

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Breast milk is the best nutrient to reduce the pain in nursing mothers and death in infants. However, for nursing mothers, too little milk volume is the cause of problems occurring during the breastfeeding process. Thus, mothers who breastfeed should consume foods that can increase the breast milk volume. One food frequently consumed by mothers to increase breast milk is honey. In fact, natural honey is challenging to discover, and the price is also high which makes it as an obstacle. A more economical alternative is required, one of which is black cumin. It is easy to obtain and the price is also affordable. Black cumin also contains galactagogue to increase prolactin that influences breast milk production. The objective of this study is to identify the effect of black cumin on the volume of breast milk. The study was a randomized controlled trial involving 60 breastfeeding mothers divided into intervention groups and control groups. The intervention group was provided 15 grams of black cumin brewed with 1000C boiling water as much as 200 ml, and the control group was assigned 15 grams of pure honey brewed boiling 1000C as much as 200 ml. Intervention and control were administered on the second day to the day of completion after giving birth. They were measuring instruments which accustomed to measure breast milk pumps. Bivariate analysis employing the Wilcoxon and Mann Whitney tests presented a significant difference between the volume of breast milk (p = 0.001) of the control and intervention groups. This study recommends the application of black cumin as a strategy to increase the volume of breast milk in nursing mothers.

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The effect of Nigella sativa on non-alcoholic fatty liver disease: A systematic review and meta-analysis

Cited by 4 publications

References 42 publications

Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses

Black Seeds

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

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