The effect of nimodipine and prednisolone on traumatic facial nerve injury treatment

Abstract

Özet: Nimodipin ve prednizolonun travmatik fasiyal sinir hasar› üzerine etkisi Amaç: Çal›flman›n amac› klempleme ile periferik fasiyal paralizi oluflturulmufl hayvan modelinde nimodipin ve prednizolon tedavisinin histopatolojik etkisini araflt›rmakt›r. Yöntem: Bukkal sinir dallar› klemplenerek fasiyal sinir felci oluflturulmufl 28 Yeni Zelanda orijinli tavflan, yediflerlik 4 gruba ayr›ld› ve her bir gruba 21 gün boyunca nimodipin, metilprednizolon ve nimodipin-metilprednizolon kombinasyonu uyguland›. Tedavi sonras›nda hasarl› nöral dokular histopatolojik olarak perinöral fibrozis, kollajen dejenerasyonu, aksonal dejenerasyon, miyelin dejenerasyonu, Schwann hücre proliferasyonu, normal miyelin yap›s› ve ödem aç›-s›ndan incelendi. Gruplar birbirleriyle ve kontrol grubuyla karfl›lafl-t›r›ld›. Bulgular: Kollajen liflerde art›fl, miyelin dejenerasyonu, aksonal dejenerasyon ve miyelin yap›s› aç›s›ndan nimodipin grubu ile kontrol grubu aras›nda; nimodipin grubu ile metilprednizolon grubu aras›nda ve nimodipin grubu ile nimodipin-metilprednizolon kombinasyon grubu aras›nda ise ödem oluflumu aç›s›ndan istatistiksel olarak anlam-l› farkl›l›k belirlendi (p<0.05). Metilprednizolon grubu ile kontrol grubu aras›nda kollajen liflerde art›fl, miyelin dejenerasyonu, aksonal dejenerasyon ve ödem, nimodipin-metilprednizolon kombinasyonu ile kontrol grubu aras›nda da kollajen liflerde art›fl, miyelin dejenerasyonu, aksonal dejenerasyon ve normal miyelin yap›s› ve ödem aç›s›ndan istatistiksel aç›dan anlaml› veriler saptand› (p<0.05). Sonuç: Hem nimodipin hem de metilprednizolon sinir bütünlü¤ü korunmufl travmatik sinir paralizisi üzerine olumlu etkilere sahiptir. Ancak nimodipinin metilprednizolona göre daha avantajl› oldu¤u ileri sürülemez.

Prophylactic Eyebrow Fixation Following Temporal Nerve Sacrifice in Cancer Surgery

“…It is clear that recovery of nerve graft is not good under skin graft, and surgeons may look for other options to overcome subsequent brow ptosis. Dolen et al ( 2017) on an experimental study on 28 rabbits we have developed a hypothesis of a chemical agent which prevents excessive calcium transition into the cell, with an assumption of having a role in diminishing mechanically induced nerve injury, therefore improving tissue recovery demonstrated the accelerating effect of nimodipine on neural tissue healing, but despite its attractiveness, it seems ineffective under fibrotic tissues of grafted skin and should be evaluated in clinical trials with more details [5].…”

Regenerative Impact (Capacity) of Cerebrolysin versus N-Acetyl- Cysteine on Facial Nerve injury in Rats

“…The proper diagnosis and early treatment is the most important principle for all physicians in management of FN pathology [5] .However, the treatment with surgical intervention is essential in injuries associated with immediate complete paralysis, which are unlikely to have spontaneous recovery, because of the presumed neuronal disorder [6] .Many therapeutic agents (such as: steroids, nimodipine, oxytocin...etc.) have been suggested for years to improve neural function and shorten recovery period, and investigations still go on [7,8] .…”

“…Many therapeutic agents (such as: steroids, nimodipine, oxytocin...etc.) have been suggested for years to improve neural function and shorten recovery period, and investigations still go on [7,8] .…”