The Effect of Nos3 and Agtr1 Genotypes on the Course of the Arterial Hypertension for the Overweight or Obese Patients

Потаскалова, В. С.; Khaitovych, Nick V.; Natrus, L.V.; Abdriakhimova, Tsira B; Kleban, K. I.; Lunov, Vitalii; Korop, Oleg A

doi:10.36740/wlek202202137

Cited by 2 publications

(1 citation statement)

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“…The phenomenon of adaptation potential (Wolf & Weissing, 2010) is considered on the level of models of adaptation personal differences that are delayed by conditions of agitation and motivational conditions, conditioned by genetic, physiological, neurobiological, and cognitive systems lying in the basis of individual behavior (Potaskalova et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Russian Military Aggression on the Psychological Health of Ukrainian Youth

Lunov

Lytvynenko

Maltsev³

et al. 2022

American Behavioral Scientist

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The article presents the results of research on the main individual behavior problems of Ukrainian youth in the conditions of Russian political and military aggression since 2014. Research is aimed at issues of adaptation potential, social and psychological security, psychological health, and well-being of young people from all geographic regions of Ukraine. The concept of “socially determined coping constructs” is proposed and the influence of interpersonal behavior style on the resourcefulness and adaptive potential of youth in the conditions of military operations is determined. Prognostic indicators of young people’s experience of security in the conditions of an unpredictable long-term scenario of military aggression are concise. It has been proved that adaptation potential is a factor of preservation of psychological health that is methodologically considered within the paradigm of humanistic psychology within the range of the concept of resilience, psychological well-being, and personal maturity. Interpersonal behavior can be considered by us as a developed form of interaction of personal genesis and social induced predisposition of a certain objectified relation. Adaptation potential is determined as a social-psychological integral hierarchical-parity formation that ensures homeostasis of mature functioning of personality within the conditions of social stress induced by the activity of adaptation capabilities, their latency, timeliness, correspondence with subjective resources, and vectors of social actualization. There has been an empirical establishment of predictors determining the impact of special features of the style of interpersonal behavior on index of perceived stress, index of coping resources, positive attitude to others, autonomy, environment management, personal development, life goals, self-perception, psychological well-being, inclusion, control, risk acceptance, and resilience. The results of our research became the basis for determination of the phenomenon of interpersonal behavior as predictor of the triad: interpersonal communication, adaptation potential, and psychological health of youth.

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Section: Introductionmentioning

confidence: 99%

The Impact of Russian Military Aggression on the Psychological Health of Ukrainian Youth

Lunov

Lytvynenko

Maltsev³

et al. 2022

American Behavioral Scientist

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Profile of Risk Factors for Hypertension Among Overweight Patients

Viktoriia

Mariana

Yaroslav

et al. 2023

FMEP

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A third part of the world’s population has a steady increased blood pressure (BP). According to scientific data, there is a tendency to increase the incidence of arterial hypertension (AH) up to 60 %. It is important in AH treatment to perform an optimal control of BP level, for this purpose it is necessary to consider both the risk factors for the disease development and the risk factors for the development of pathology complications. The objective: to identify risk factors in patients with AH and body mass index (BMI) more than 25 kg/m2. Materials and methods. The study included 339 patients with AH. The I group involved 299 persons with BMI≥25 kg/m2, and 40 patients with AH and BMI <25 kg/m2 were included in the II group. The average age of the patients was 49.4±10.7 years, the average duration of the disease – 7.5 years. Anthropometric data, daily monitoring of BP, morphological and functional state of the heart, biochemical parameters of the blood (lipidogram, transaminase and bilirubin, urea and creatinine, glucose level) were determined in all patients. The levels of interleukin-1β, interleukin-10 and homocysteine were also detected. The speed of glomerular filtration was determined accord ing to the Cockroft–Hault formula, a psycho-emotional examination was done (a questionnaire for determining of anxiety and depression levels, the presence of alexitimia). Results. The analysis of the lipidogram indicators demonstrated a higher level of atherogenicity index in patients with excess body weight (respectively 3.4±1.3 versus 3.1±1.4; p<0.05). Among patients with AH and overweight or obesity compared to patients with normal body weight, significant differences have been revealed about the frequency of complications of targetorgans (AH stage II was 2 times more common among patients in the II group). Glycemia level on empty stomach was higher in patients with overweight (5.5±1.8 mmol/l versus 4.8±0.8 mmol/l; p>0.05) and 3 times more common among patients in the I group (35.6 % versus 11.5 % of patients; p<0.05). Hyperuricemia was found in 48 % of patients. In patients with normal BMI, the level of uric acid was within reference values (p=0.015). In 27 % of patients with overweight the increased IL-10 was determined, in 45 % – IL-1β, while in patients with normal BMI these indicators were normal (p<0.05). Patients with AH had increased levels of anxiety, and patients with excess weight had a risk of depression. Conclusions. The results of the study showed that there is a clear association of increased blood pressure (BP) with weight gain. Patients with AH and high body mass index (BMI) had additional risk factors that can cause high BP and require personalized treatment. Excessive body weight causes an acceleration of the development of target organs (1.5 times more often), in particular increases the risk of progression of systolic and diastolic dysfunction of the left ventricle and sudden cardiac arrest, leads the development of atherosclerosis and immune inflammation. The association of AH and high BMI with PPARG gene (33 % of cases) was determined.

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The Effect of Nos3 and Agtr1 Genotypes on the Course of the Arterial Hypertension for the Overweight or Obese Patients

Cited by 2 publications

References 81 publications

The Impact of Russian Military Aggression on the Psychological Health of Ukrainian Youth

The Impact of Russian Military Aggression on the Psychological Health of Ukrainian Youth

Profile of Risk Factors for Hypertension Among Overweight Patients

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