The Effect of Omega-3 Fatty Acids on Bronchial Hyperresponsiveness, Sputum Eosinophilia, and Mast Cell Mediators in Asthma

Brannan, John D.; Bood, Johan; Alkhabaz, Ahmad; Balgoma, David; Otis, Joceline; Delin, Ingrid; Dahlén, Barbro; Wheelock, Craig E.; Nair, Parameswaran; Dahlén, Sven‐Erik; O'Byrne, Paul M.

doi:10.1378/chest.14-1214

Cited by 41 publications

(43 citation statements)

References 30 publications

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“…; Brannan et al. ). These studies reported a decrease in activation of immune cells without changing the severity of asthma.…”

Section: Discussionmentioning

confidence: 97%

“…It was also of prime interest to identify a specific compound that could significantly oppose the inflammatory status and would result in a decrease in airway hyperresponsiveness induced by various proinflammatory cytokines or culture of native guinea pig tracheal explants. Various studies have reported conflicting data regarding the clinical value of nÀ3 polyunsaturated fatty acid in the treatment of asthma (Reisman et al 2006;Brannan et al 2015). These studies reported a decrease in activation of immune cells without changing the severity of asthma.…”

Section: Discussionmentioning

confidence: 99%

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MAG ‐ DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine‐triggered hyperresponsive airway models

Khaddaj‐Mallat

Hiram

Sirois

et al. 2016

Pharmacol Res Perspect

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Bronchial inflammation contributes to a sustained elevation of airway hyperresponsiveness (AHR) in asthma. Conversely, omega‐3 fatty acid derivatives have been shown to resolve inflammation in various tissues. Thus, the effects of docosapentaenoic acid monoacylglyceride (MAG‐DPA) were assessed on inflammatory markers and reactivity of human distal bronchi as well as in a cultured model of guinea pig tracheal rings. Human bronchi were dissected and cultured for 48 h with 10 ng/mL TNF‐α or IL‐13. Guinea pig tracheas were maintained in organ culture for 72 h which was previously shown to trigger spontaneous AHR. All tissues were treated with increasing concentrations of MAG‐DPA (0.1, 0.3, and 1 μmol/L). Pharmacomechanical reactivity, Ca2+ sensitivity, and western blot analysis for specific phosphoproteins and transcription factors were performed to assess the effects of both cytokines, alone or in combination with MAG‐DPA, on human and guinea pig airway preparations. Although 0.1 μmol/L MAG‐DPA did not significantly reduce inflammatory biomarkers, the higher concentrations of MAG‐DPA (0.3 and 1 μmol/L) blunted the activation of the TNF‐α/NF κB pathway and abolished COX‐2 expression in human and guinea pig tissues. Moreover, 0.3 and 1 μmol/L MAG‐DPA consistently decreased the Ca2+ sensitivity and pharmacological reactivity of cultured bronchial explants. Furthermore, in human bronchi, IL‐13‐stimulated phosphorylation of CPI‐17 was reversed by 1 μmol/L MAG‐DPA. This effect was further amplified in the presence of 100 μmol/L aspirin. MAG‐DPA mediates antiphlogistic effects by increasing the resolution of inflammation, while resetting Ca2+ sensitivity and contractile reactivity.

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“…; Brannan et al. ). These studies reported a decrease in activation of immune cells without changing the severity of asthma.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

MAG ‐ DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine‐triggered hyperresponsive airway models

Khaddaj‐Mallat

Hiram

Sirois

et al. 2016

Pharmacol Res Perspect

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“…Interestingly, not only PUFAs, but also n-9 MUFAs (OA) and the high consumption of olive oil decrease the risk of asthma [235]. However, several other groups found that PUFA supplementation is not beneficial for pulmonary health [236][237][238][239][240][241][242][243][244][245][246][247]. Finally, n-3 PUFA intake in children can be also associated with an increased risk of wheeze [248], allergic rhinitis, eczema, and allergic sensitization up to 18 years of age and with reduced lung function at the age of 12 years [249] (Table 3).…”

Section: Asthmamentioning

confidence: 99%

The Influence of Dietary Fatty Acids on Immune Responses

et al. 2019

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Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.

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“…In fact, two separate birth cohort studies showed no link between maternal dietary intake of n-3 or n-6 PUFAs (or their ratio) and wheeze or allergic disease before age 2.5 years (41, 42), and a third independent birth cohort study found no significant association between n-3 or n-6 PUFAs in cord blood and asthma, allergic rhinitis or eczema up to age 10 years (43). Findings from three recent randomized controlled trials provide further negative or inconclusive evidence for beneficial effects of n-3 PUFAs (as both EPA and DHA, or as DHA only) on the prevention (through prenatal administration) (44, 45) or treatment(46) of asthma or allergies in early childhood (up to age 3 years) (44, 45) or adulthood (46). Thus, it is not surprising that two recent systematic reviews concluded that there is insufficient evidence to recommend supplementation with fish oil or any fatty acid (including arachidonic acid) for the prevention or treatment of asthma or allergies (47, 48).…”

Section: Introductionmentioning

confidence: 99%

Diet and asthma

Han

Forno

Holguín

et al. 2015

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Our objective is to provide an overview and discussion of recent experimental studies, epidemiologic studies, and clinical trials of diet and asthma. We focus on dietary sources and vitamins with antioxidant properties (vitamins (A, C, and E), folate, and omega-3 and omega-6 polyunsaturated fatty acids (n-3 and n-6 PUFAs). Recent findings Current evidence does not support the use of vitamin A, vitamin C, vitamin E or PUFAs for the prevention or treatment of asthma or allergies. Current guidelines for prenatal use of folate to prevent neural tube defects should be followed, as there is no evidence of major effects of this practice on asthma or allergies. Consumption of a balanced diet that is rich in sources of antioxidants (e.g. fruits and vegetables) may be beneficial in the primary prevention of asthma. Summary None of the vitamins or nutrients examined is consistently associated with asthma or allergies. In some cases, further studies of the effects of a vitamin or nutrient on specific asthma phenotypes (e.g. vitamin C to prevent viral-induced exacerbations) are warranted. Clinical trials of “whole diet” interventions to prevent asthma are advisable on the basis of existing evidence.

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The Effect of Omega-3 Fatty Acids on Bronchial Hyperresponsiveness, Sputum Eosinophilia, and Mast Cell Mediators in Asthma

Cited by 41 publications

References 30 publications

MAG ‐ DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine‐triggered hyperresponsive airway models

MAG ‐ DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine‐triggered hyperresponsive airway models

The Influence of Dietary Fatty Acids on Immune Responses

Diet and asthma

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