The Effect of Osteoclastic Activity on Tendon-to-Bone Healing

Abstract

Osteoprotegerin significantly improves bone formation around the grafted tendon and improves the stiffness at the healing tendon-bone junction in a rabbit model.

Influence of bone adaptation on tendon‐to‐bone healing in bone tunnel after anterior cruciate ligament reconstruction in a rabbit model

“…Increased osteoclastic activities were accompanied by less bone mineral apposition and poor T-B healing. Rodeo et al 10 evaluated the role of osteoclastic bone resorption in T-B healing after ACL reconstruction in rabbit by modulating osteoclastic activities using osteoprotegerin and the receptor activator of nuclear factor-kappa B ligand. Activation of osteoclasts resulted in less peri-graft bone and a decrease of the stiffness of T-B complexes.…”

“…Activation of osteoclasts resulted in less peri-graft bone and a decrease of the stiffness of T-B complexes. 10 Bisphosphonate, an inhibitor of bone resoprtion, has been studied in an attempt to augment T-B healing in bone tunnel. 5,24 Although satisfactory results were shown after systemic administration of bisphosphonates, our histomorphological evaluation implied that local administration, that is, at the posterior and lateral regions of the tibial tunnel, would be more .…”

“…According to Wolff's Law, 9 the persistent stress shielding in these regions might result in bone resorption, and interfere with T-B healing subsequently. 10 It was hypothesized that the postoperative bone adaptive changes and associated T-B healing were region-dependent. The present study was designed to investigate the spatiotemporal changes of peri-graft bone mass and microarchitecture, and to compare radiological findings with histological findings of T-B healing following ACL reconstruction in rabbit.…”

Effect of Early and Delayed Mechanical Loading on Tendon-to-Bone Healing After Anterior Cruciate Ligament Reconstruction

“…Trabecular architecture, bone formation, and bone remodeling along the tendon-bone interface were assessed with use of microcomputed tomography (MS-8 Small Specimen Scanner; Enhanced Vision Systems, London, Ontario, Canada) 24,25 . Time-zero analysis was also performed on five specimens to provide a baseline reference for comparison with the control and experimental groups.…”

Effect of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization on Tendon-Bone Healing After ACL Reconstruction in a Rat Model

“…In that study, the areas with more motion and osteoclasts also had the slowest graft-to-tunnel healing time, suggesting that increased motion in the early postoperative stages may negatively impact tendon-bone healing. A previous rabbit model of ACL reconstruction also showed that inhibiting osteoclastic activity with osteoprotegerin improved bone formation at the tendon-bone interface as compared with that seen in animals that received RANKL to stimulate osteoclast activity 20 . In contrast to the current study, that study found increased stiffness of the bone-graft-bone construct in the group with osteoclast inhibition, which may be due to the different levels of osteoclast stimulation and inhibition that were brought about by the pharmacological treatments.…”