The Effect of Ozone Gel on Bone Regeneration Following Enucleation of Maxillary Cysts

Abstract

Introduction: Reconstruction of bony defects represents a challenging problem for the surgical community. ozone therapy seems to be a promising future in different dental modalities that may be effective in treating bony defects. Objectives:The aim of this study was to assess the effect of topical ozone gel application on bone regeneration following enucleation of maxillary cysts. Materials and methods:After surgical enucleation of odontogenic maxillary cystic lesions in sixteen patients, eight bony defects were grafted with ozone gel; the second group served as controls. Computed multi-slice CT scans were obtained immediately after surgery, -6 and -9months post-surgery to assess the decrease in bone defect size and density of newly formed bone. Results:The study group showed significant increase in bone density of newly formed bone at 6& 9 months postsurgical (p= 0.039, 0.042) and significant decrease in bone defect size as it recorded a mean percentage of residual area of bone defect in axial cuts 39.46± 9.17, 22.52 ± 7.02 while control group recorded a mean of 64.08 ± 9.88, 49.74 ± 10.96 at 6& 9months respectively.Conclusions: Ozone gel can be considered a healing biomaterial, as it features all the necessary parameters permitting bone regeneration without any adverse reaction. It gives a predictable clinical and radiographic evidence of bone formation and faster healing than control group.

Polymeric biomaterials for periodontal tissue engineering and periodontitis

“…7% at 9 months after the surgical procedure. 129 The continuous secretion of oxygen to tissues with hypoxia in specific doses is an area that is still being studied and its limitations are still being overcome. Apart from the mentioned oxygen transport system and methods, new approaches such as oxygen high level laser therapy, which have been less studied, are available in the literature.…”