The effect of pentavalent antimonial compounds used in the treatment of cutaneous leishmaniasis on hemogram and biochemical parameters

An, İsa; Harman, Mehmet; Esen, Mustafa; Çelik, Hakim

doi:10.1080/15569527.2019.1610887

Cited by 16 publications

(21 citation statements)

References 20 publications

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“…Cutaneous leishmaniasis (CL) is a skin disease with long‐lasting non‐healing lesions on the skin transmitted to humans by the bite of the infected female gnat 7‐9 . Superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH‐Px) and malondialdehyde (MDA) levels were evaluated and it was shown that oxidative stress plays a role in the etiopathogenesis of this disease 10‐13 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis

Sebel¹,

Aksoy

et al. 2021

Int J Clin Pract

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Objective The aim of this study was to evaluate serum thiol disulphide levels in patients with cutaneous leishmaniasis (CL) compared with a healthy control group and to investigate whether thiol/disulphide balance can be used as a new marker of oxidative stress in CL patients. Material and Methods This prospective study included 47 patients diagnosed with CL and 46 healthy individuals without any disease. Native thiol, disulphide and total thiol levels were used in plasma. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured. Results Disulphide, native thiol disulphide and total thiol disulphide levels were significantly lower in CL patients compared with the control group. However, there was no statistically significant difference between CL patients and the control group in terms of disulphide/native thiol, disulphide/total thiol and native thiol/total thiol values. Conclusion Based on the data in our study, it can be said that the use of thiol/disulphide balance as a new oxidative stress marker in CL patients is not appropriate, but studies with a larger number of patients are needed.

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Section: Introductionmentioning

confidence: 99%

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis

Sebel¹,

Aksoy

et al. 2021

Int J Clin Pract

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“…Cutaneous leishmaniasis (CL) lesion begins as an erythematous papule on areas not covered by clothing, such as the face, neck and extremities bitten by the infected female sand fly. It grows slowly and turns into a nodule or plaque with a tightly adhered crusted ulcer after weeks‐months and usually heals itself by leaving a scar within 3‐6 months 1‐5 …”

Section: Introductionmentioning

confidence: 99%

“…It grows slowly and turns into a nodule or plaque with a tightly adhered crusted ulcer after weeksmonths and usually heals itself by leaving a scar within 3-6 months. [1][2][3][4][5] In addition to the classical clinical form, unusual morphological variants such as paronychial, sporotrichoid, psoriasiform, erysipelas-like, chancriform, eczematoid, zosteriform and verrucous have been described. [6][7][8][9][10][11][12][13] The aim of this study was to investigate the clinical features of 27 patients with atypical and unusual morphological variants of CL diagnosed in our clinic.…”

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confidence: 99%

Atypical and unusual morphological variants of cutaneous leishmaniasis

Aksoy

Öztürk

et al. 2020

Int J Clin Pract

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Objective Cutaneous leishmaniasis (CL) is a skin disease characterised by prolonged nodulo‐ulcerative lesions of the skin that heals with atrophic scar. Clinical features of CL vary depending on the type of parasite and host immune resistance. The aim of this study was to investigate the clinical features of atypical and unusual morphological variants of CL patients diagnosed in our clinic. Materials and Methods In this prospective study, 27 CL patients with atypical clinical features among 486 patients admitted to our clinic between July 2018 and September 2019 and diagnosed as CL by slit‐skin smear examination or histopathological examination were included. Results Of 27 patients, 15 (55.5%) were male and 12 (44.5%) were female. The mean age of the patients was 25.8 ± 7.62 years. Seven (25.9%) patients had lupoid lesions, five (18.6%) patients had eczematoid lesions, four (14.8%) patients had lip lesions, three (11.1%) patients had erysipelas‐like lesions, two (7.4%) patients had eyelid lesions, two (7.4%) patients had sporotrichoid lesions, two (7.4%) patients had verrucous lesions, one (3.7%) patient had psoriasiform lesion and one (3.7%) patient had paronychial lesion. Conclusion In conclusion, rare clinical forms of CL are presented in this study. It should be kept in mind that CL may have very different clinical features and should be considered in the differential diagnosis of eczema, psoriasis, erysipelas, sporotrichosis, paronychia and verrucous lesions.

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“…Despite the efforts involved in the development of new chemotherapeutic options/alternatives, the use of pentavalent antimony compounds still remains the first-line treatment today [7]. These drugs are recognized by their side effects [8][9][10], which implies an additional effort to monitor patients under treatment [11]. Moreover, the increasing number of therapeutic failure (mainly associated with parasite drug resistance) [12,13] establishes the need to persist in the search for more effective and safer antileishmanial agents.…”

Section: Introductionmentioning

confidence: 99%

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

2020

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Leishmaniasis is a parasitic morbid/fatal disease caused by Leishmania protozoa. Twelve million people worldwide are appraised to be currently infected, including ca. two million infections each year, and 350 million people in 88 countries are at risk of becoming infected. In Colombia, cutaneous leishmaniasis (CL) is a public health problem in some tropical areas. Therapeutics is based on traditional antileishmanial drugs, but this practice has several drawbacks for patients. Thus, the search for new antileishmanial agents is a serious need, but the lack of adequately funded research programs on drug discovery has hampered its progress. Some Colombian researchers have conducted different research projects focused on the assessment of the antileishmanial activity of naturally occurring and synthetic compounds against promastigotes and/or amastigotes. Results of such studies have separately demonstrated important hits and reasonable potential, but a holistic view of them is lacking. Hence, we present the outcome from a systematic review of the literature (under PRISMA guidelines) on those Colombian studies investigating antileishmanials during the last thirty-two years. In order to combine the general efforts aiming at finding a lead against Leishmania panamensis (one of the most studied and incident parasites in Colombia causing CL) and to recognize structural features of representative compounds, fingerprint-based analyses using conventional machine learning algorithms and clustering methods are shown. Abstraction from such a meta-description led to describe some function-determining molecular features and simplify the clustering of plausible isofunctional hits. This systematic review indicated that the Colombian efforts for the antileishmanials discovery are increasingly intensified, though improvements in the followed pathways must be definitively pursued. In this context, a brief discussion about scope, strengths and limitations of such advances and relationships is addressed.

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The effect of pentavalent antimonial compounds used in the treatment of cutaneous leishmaniasis on hemogram and biochemical parameters

Cited by 16 publications

References 20 publications

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis

Atypical and unusual morphological variants of cutaneous leishmaniasis

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

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