The Effect of Perinatal Hypoxia on Red Blood Cell Morphology in Newborns

Перепелица, С. А.; Сергунова, В. А.; Гудкова, О. Е.

doi:10.15360/1813-9779-2017-2-14-23

Cited by 6 publications

(4 citation statements)

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“…Our findings show that incubation of erythrocytes under hypoxia is detrimental to the membrane-skeletal proteins. One factor that diminishes the content of membrane-skeletal proteins is the increased formation of reactive oxygen species, which not only boost the oxidative processes in the lipid phase, but also cause damage to proteins [66]. This is evident from our findings on the accumulation of LPO products in erythrocytes during hypoxia.…”

Section: Discussionmentioning

confidence: 62%

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Revin

Gromova

Revina

et al. 2019

BioMed Research International

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This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells and altered quantitative and qualitative composition of membrane-skeletal proteins. The findings suggest that hypoxia causes changes at all levels of red blood cell organization, which can cause the functional disorders of hemoglobin oxygen-transporting properties and, eventually, the complete degradation of red blood cells. The use of flavonoids has a protective effect against hypoxia.

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Section: Discussionmentioning

confidence: 62%

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Revin

Gromova

Revina

et al. 2019

BioMed Research International

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“…Hypoxemia and hypoxia can also develop in newborns due to abnormalities during pregnancy [ 17 , 18 , 19 , 20 ]. Perinatal hypoxia can affect RBC morphology and membrane nanostructure [ 21 ]. Disturbances in blood oxygen delivery may occur at high altitude in the mountains [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Atomic Force Microscopy and High-Resolution Spectrophotometry for Study of Anoxemia and Normoxemia in Model Experiment In Vitro

Козлова

Sherstyukova

Сергунова

et al. 2023

IJMS

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The oxygen content in the blood may decrease under the influence of various physicochemical factors and different diseases. The state of hypoxemia is especially dangerous for critically ill patients. In this paper, we describe and analyze the changes in the characteristics of red blood cells (RBCs) with decreasing levels of oxygen in the RBC suspension from normoxemia to hypoxemia/anoxemia in an in vitro model experiment. The RBCs were stored in hypoxemia/anoxemia and normoxemia conditions in closed and open tubes correspondingly. For the quantitative study of RBC parameter changes, we used atomic force microscopy, digital spectrophotometry, and nonlinear curve fitting of the optical spectra. In both closed and open tubes, at the end of the storage period by day 29, only 2% of discocytes remained, and mainly irreversible types, such as microspherocytes and ghosts, were observed. RBC hemolysis occurred at a level of 25–30%. Addition of the storage solution, depending on the concentration, changed the influence of hypoxemia on RBCs. The reversibility of the change in hemoglobin derivatives was checked. Based on the experimental data and model approach, we assume that there is an optimal level of hypoxemia at which the imbalance between the oxidative and antioxidant systems, the rate of formation of reactive oxygen species, and, accordingly, the disturbances in RBCs, will be minimal.

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“…Red blood cells (RBC) are the most important cells that, on the one hand, perform the oxygen transport, and on the other hand, they are subject to changes when exposed to hypoxia [4][5][6]. The RBC's structure is optimal for its main function: efficient oxygen delivery and CO 2 removal.…”

Section: Introductionmentioning

confidence: 99%

“…Progressing changes in RBC shapes are accompanied by impairment of the cytoskeleton and plasma membrane, decreased intracellular adenosine triphosphate (ATP) concentration, as well as changes in the functional characteristics of RBC: reduced transport function and increased membrane deformability [4].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Morphologic State of Red Blood Cells in Patients With Polytrauma

Matvieienko

Gryshchenko

Baranova

et al. 2020

EUREKA: Health Sciences

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The measurement of RBC indices is of particular importance as an indirect intermediate component of the recovery process after exposure to hypoxia, ischemia, hypothermia in patients with traumatic disease due to polytrauma. The aim of this study was to evaluate the parameters of the morphologic state of red blood cells as a reaction of patients with traumatic disease. Materials and methods.A prospective study was carried out evaluation of 120 patients suffering from polytrauma. The patients were divided into 3 groups according to the principle of using additional substances as a part of IC. The parameters of morphologic state of red blood cells were studied. Results and discussion. The course of acute and early periods of traumatic disease has accompanied variability morphological forms of red blood cells, as evidenced by a decrease in MCV and RDW increased levels of the 3rd to 5th day. The optimized therapy used in the treatment of patients, has a positive effect on the parameters of red blood cells, contributes to a better recovery of red blood cells after hypoxia resulting multiple trauma. Conclusion. The study has demonstrated variations in the morphologic properties of red blood cells in the acute and early period of traumatic disease, as confirmed by pathological changes of the erythrocyte indices. The administration of the proposed therapy with the use of D-fructose-1.6-diphosphate sodium salt of hydrate has a positive effect on the parameters of red blood cells, contributes to a better recovery after hypoxia resulting multiple trauma. Given this, the calculations of the red blood cell indices may carry additional diagnostic information, which allows identify trends for not obvious pathological changes and quality of treatment.

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The Effect of Perinatal Hypoxia on Red Blood Cell Morphology in Newborns

Cited by 6 publications

References 0 publications

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

Atomic Force Microscopy and High-Resolution Spectrophotometry for Study of Anoxemia and Normoxemia in Model Experiment In Vitro

Changes in the Morphologic State of Red Blood Cells in Patients With Polytrauma

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