The effect of pH in modulating skin cell behaviour

Sharpe, Justin R.; Harris, Kathryn L.; Jubin, K.; Bainbridge, Natalie J.; Jordan, Nigel

doi:10.1111/j.1365-2133.2009.09168.x

Cited by 81 publications

(62 citation statements)

References 7 publications

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“…This is an important aspect of the skin's barrier function, since it regulates bacterial flora and prevents infection. 29 When a wound occurs, the skins acidic milieu and pH is disrupted, exposing the more neutral pH (7.4) of the underlying tissue. 2 With successful healing and re-epithelialization, the skin returns to being acidic.…”

Section: The Ecmmentioning

confidence: 99%

“…9 Skin keratinocytes tolerate a much wider pH range compared with fibroblasts and show optimal migration at pH 8.5, far more alkaline than fibroblasts can tolerate. 29 If changes in pH can change the behavior of the skin keratinocyte and fibroblast cells, then it may also consequently modify the wound healing process. An alkaline pH could be beneficial for increased epithelial growth; however, an alkaline environment would also be more advantageous for microbial growth and infection.…”

Section: The Ecmmentioning

confidence: 99%

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The Effect of pH on the Extracellular Matrix and Biofilms

Jones

Cochrane

Percival

2015

Advances in Wound Care

341

252

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Section: The Ecmmentioning

confidence: 99%

Section: The Ecmmentioning

confidence: 99%

The Effect of pH on the Extracellular Matrix and Biofilms

Jones

Cochrane

Percival

2015

Advances in Wound Care

341

252

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“…It goes without saying that cell proliferation is absolutely essential for wound closure. A recent study investigated the impact of pH alterations on the proliferation and migration of keratinocytes and fibroblasts 44 . Interestingly, the optimum for keratinocyte migration was found for a pH of 8.55.…”

Section: Introductionmentioning

confidence: 99%

The impact of the pH value on skin integrity and cutaneous wound healing

Schreml

Karrer

et al. 2010

Acad Dermatol Venereol

226

153

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The process of cutaneous wound healing comprises three overlapping major phases: inflammation, proliferation and tissue remodelling. However, while mechanisms are studied scientifically on the cellular and subcellular level, there is still a lack of knowledge concerning basic clinical parameters like wound pH or pO2. It could be proven that wound healing is affected by wound pH changes as they can lead to an inhibition of endogenous and therapeutically applied enzymes. Besides, the conformational structure of proteins and their functionality in wound healing is altered. Furthermore, the likelihood of bacterial colonization, which is a common problem in chronic wound pathogenesis, is affected by wound pH alterations. However, wound pH is rarely taken into account in current wound therapy strategies. A routinely performed monitoring of the wound pH and a subsequently adapted wound therapy would most possibly improve chronic wound therapy.

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“…This pH value of the powder slurry is an optimal pH value for cells, such as keratinocytes and fibroblasts proliferation during the wound healing process. 27) Change in the concentration of Zn 2+ and Si 4+ ions released from the Zn-smectite in physiological saline is shown in Fig. 4 …”

Section: )25)mentioning

confidence: 99%

<i>In vivo</i> evaluation of wound healing property of zinc smectite using a rat model

Sasaki

Sathi

Yamamoto

2016

J. Ceram. Soc. Japan

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Zinc, magnesium and silicon ions are known as bioactive ions that promote the hard and soft tissue regeneration. We hypothesized that Zn-smectite consisting of zinc and silicon ions provide a more potential biomaterial in regenerative medicine field. Zn-smectite powder was thus synthesized in this study and used for wound healing. The aim of the present work was to evaluate the effect of Zn-smectite on wound healing in rats. An aqueous solution was prepared by dissolving zinc chloride (ZnCl 2 ) and water glass in distilled water, and then refluxed at 90°C for 12 h; after which crystalline Zn-smectite powder was obtained. The amount of Zn 2+ and Si 4+ ions releasing from Zn-smectite in physiological saline was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). It was observed that the amount of the Zn 2+ ion released from the Zn-smectite powder increased with the soaking time, but the released amount of Si 4+ ion decreased with the soaking time. To evaluate the biofunctional ability, Zn-smectite was applied to a full thickness surgical wound created in the rat's abdomen. In the results for skin regeneration, there was no significant difference in wound size between the control and Zn-smectite group at 1 and 2 weeks. However, it was observed that Zn-smectite promoted greater vascular regeneration and more skin appendages in comparison with the control. Zn-smectite can be expected to stimulate wound healing and heal the tissue close to the native tissue by releasing Zn 2+ and Si 4+ ions, suggesting that this newly formed material could offer greater potentiality in the field of regenerative medicine.

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The effect of pH in modulating skin cell behaviour

Cited by 81 publications

References 7 publications

The Effect of pH on the Extracellular Matrix and Biofilms

The Effect of pH on the Extracellular Matrix and Biofilms

The impact of the pH value on skin integrity and cutaneous wound healing

<i>In vivo</i> evaluation of wound healing property of zinc smectite using a rat model

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