The effect of photodynamic therapy on pathogenic bacteria around peri‐implant sulcus and in the cavity between abutment and implant after healing phase: A prospective clinical study

Zhou, Liyun; Shi, Jia; Zhu, Yu; Qian, Shu‐Jiao; Lai, Hong-Chang; Gu, Yun

doi:10.1002/lsm.22929

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…In addition, different bacteria could have different sensitivity to the therapy. A study showed that PDT reduced the population of P. gingivalis , but it did not observe the other bacteria . This could be explored in future studies.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Wang

Zhang

et al. 2019

Australian Dental Journal

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Background: Photodynamic therapy (PDT) can be used for the management of peri-implantitis. This study aimed to explore the efficacy and safety of PDT for peri-implantitis in Chinese Han patients. Methods: This was a single-centre, open-label, randomized controlled trial of participants with peri-implantitis treated at the Beijing Chao-Yang Hospital, randomized 1:1 to PDT or no PDT. PDT was performed using toluidine blue (10 mg/ mL; 3 min) and a 635-nm laser (750 mW; 10 s/implant side; minimum of 60 mW/cm 2 ). The primary outcome was the decline in periodontal probing depth (PD) at 6 months. The secondary outcomes were peri-implant plaque index (PLI), sulcular bleeding index (SBI), and clinical attachment loss (CAL). Results: PD after treatment was smaller in the PDT group (n = 66) than in controls (n = 65) (all P < 0.001 vs. baseline). At 1 month, compared with controls, the PD in the PDT group was larger, while at 3-and 6-month, the PDs were smaller (all P < 0.001). CAL, PLI and SBI in the PDT group was better (P < 0.05 vs. controls). Conclusion: PDT combined with mechanical debridement significantly improves PD, PLI and SBI in participants with peri-implantitis. Importantly, PDT achieved a better CAL than mechanical debridement and cleaning.Abbreviations: AE = adverse event; CAL = clinical attachment loss; DB = distobuccal; PD = pocket depth; PDT = Photodynamic therapy; PLI = peri-implant plaque index; SBI = sulcular bleeding index.

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Section: Discussionmentioning

confidence: 99%

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Wang

Zhang

et al. 2019

Australian Dental Journal

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“…The most common way to detect bacteria is polymerase chain reaction (PCR); sometimes, RNA probes are also used. These studies found that the treatment group with additional PDT significantly reduced the expression levels of P. gingivalis , F. nucleatum , 80,105 A. actinomycetemcomitans , T. forsythia , 100 T. denticola , 76 P. intermedia , 106 Eubacterium nodatum , and Eikenella corrodens compared with the group that only performed SRP 80,87,107,108 . Some reports also show that PDT failed to demonstrate additional bacteriological benefits of P. gingivalis , A. actinomycetemcomitans , T. forsythia , and T. denticola in periodontitis patients 74,109,110 (Table 2).…”

Section: Clinical Effect Of Pdt In the Treatment Of Periodontitismentioning

confidence: 98%

“…There are three PSs approved to be used in the clinical practice of periodontal treatment, MB, TBO, and ICG, of which MB is the most commonly used. [76][77][78][79][80][81] The concentrations of PSs in clinical trials ranged from 1 to 10 mg/mL; the incubation time of PS in the periodontal pocket varied from 1 to 3 min; the wavelengths of the light used were mainly 635 and 670 nm, and also 810 80 and 940 nm 82 have been used; the diameter of fibers varied from 200 to 750 μm, while the time exposure to the light was generally 60 s, also for 30 s, 80 and 150 s 83 in some studies. The energy dose of light varies from 3 to 320 J/cm 2 .…”

Section: Pss and Light Source Of Pdt In Periodontal Adjuvant Therapymentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

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“…Various combinations of photosensitizers, light sources and protocols have Early researchers suggested that the basic procedure could be modified for the photoeradication of localized infections, antimicrobial PDT (aPDT; also known as antimicrobial photodynamic inactivation, aPDI, and photodynamic antimicrobial chemotherapy, PACT) [75][76][77]. Various combinations of photosensitizers, light sources and protocols have since been studied in dentistry as an antimicrobial treatment for periodontitis [78][79][80][81][82], periimplantitis [83][84][85][86], and root canal disinfection [87][88][89]. There is yet to evolve a standard protocol [90].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Photoinactivation and Photoablation of Porphyromonas gingivalis

Harris,

Sulewski

2023

Pathogens

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Several types of phototherapy target human pathogens and Porphyromonas gingivitis (Pg) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and mechanisms of action. Mode 1: antimicrobial ultraviolet (aUV); mode 2: antimicrobial blue light (aBL); mode 3: antimicrobial selective photothermolysis (aSP); mode 4: antimicrobial vaporization; mode 5: antimicrobial photodynamic therapy (aPDT). This report reviews the literature to identify for each mode (a) the putative molecular mechanism of action; (b) the effective wavelength range and penetration depth; (c) selectivity; (d) in vitro outcomes; and (e) clinical trial/study outcomes as these elements apply to Porphyromonas gingivalis (Pg). The characteristics of each mode influence how each is translated into the clinic.

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The effect of photodynamic therapy on pathogenic bacteria around peri‐implant sulcus and in the cavity between abutment and implant after healing phase: A prospective clinical study

Cited by 7 publications

References 37 publications

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Adjunctive photodynamic therapy improves the outcomes of peri‐implantitis: a randomized controlled trial

Photodynamic therapy in periodontitis: A narrative review

Photoinactivation and Photoablation of Porphyromonas gingivalis

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