The effect of physiologically relevant additives on the rheological properties of concentrated Pluronic copolymer gels

Jiang, Jun; Li, Chunhua; Lombardi, Jack P.; Colby, Ralph H.; Rigas, Basil; Rafailovich, Miriam; Sokolov, Jonathan

doi:10.1016/j.polymer.2008.05.038

Cited by 61 publications

(35 citation statements)

References 23 publications

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“…The micellization temperature of Pluronic F‐127 solution (22% w/v) is believed to be around 12 °C because the endothermic heat flow began around that temperature. The micellization temperature of Pluronic F‐127 solution (22% w/v) has been reported to be about 10 °C, which is not very different from the micellization temperature found in the present work. The micellization temperature of Pluronic F‐127 in an aqueous solution ranges from 8 °C to 24 °C depending on the concentration .…”

Section: Resultscontrasting

confidence: 74%

“…The micellization temperature of Pluronic F‐127 solution (22% w/v) has been reported to be about 10 °C, which is not very different from the micellization temperature found in the present work. The micellization temperature of Pluronic F‐127 in an aqueous solution ranges from 8 °C to 24 °C depending on the concentration . UV irradiation had little effect on the micellization temperature of Pluronic F‐127 solution.…”

Section: Resultscontrasting

confidence: 74%

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Photo and thermal properties of cinnamoyl Pluronic F-127

Dai

Kim

2013

Polym. Int.

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Cinnamoyl chloride was covalently attached to the ends of Pluronic F-127 chains. The molar ratio of cinnamoyl groups to Pluronic F-127 of the cinnamoyl Pluronic F-127 (Cin-Plu) was calculated to be about 1:1 on a 1 H NMR spectrum. The melting point (around 52• C) of Cin-Plu was somewhat less than that (around 55 • C) of Pluronic F-127. Furthermore, the melting point of Cin-Plu decreased to around 50• C on UV irradiation. The micellization temperature of Pluronic F-127 was around 15 • C and it was affected neither by the covalent attachment of cinnamoyl chloride nor the UV irradiation. On the other hand, Pluronic F-127 solution (22% w/v) in distilled water became a gel at around 28• C and Cin-Plu solution (22% w/v) at around 39 • C. The elevation in the gelation temperature is possibly because the cinnamoyl group interferes with the intermolecular hydrophobic interaction of propylene oxide blocks, a main cause for the gelation. Cin-Plu solution (22% w/v) which had been subjected to UV irradiation (365 nm, 400 W) for 3 h exhibited no gelation temperature but a gradual increase in viscosity when the solution temperature increased from 17• C to 37• C, possibly due to the coexistence of dimeric Cin-Plu and monomeric Cin-Plu.

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Section: Resultscontrasting

confidence: 74%

Section: Resultscontrasting

confidence: 74%

Photo and thermal properties of cinnamoyl Pluronic F-127

Dai

Kim

2013

Polym. Int.

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“…2a), in the form of a small endothermic peak, which was not present in thermograms of poloxamer at low concentrations. It has been proposed that the observed small endothermic peak is due to ordering of micelles into crystalline structures, in accordance with previous indications, obtained from SANS analysis, indicating that the micelles form a BCC cubic structure (Mortensen and Talmon, 1995;Cabana et al, 1997;Jiang et al, 2008). However, we could not obtain reproducible trend in gelation temperature while studying effect of DMSO by DSC, so simple tube inversion method was applied.…”

Section: Gelation Temperaturesupporting

confidence: 87%

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Ur-Rehman

Tavelin

Gröbner

2010

International Journal of Pharmaceutics

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“…4,19 The data were acquired in milli-Q water, but the storage modulus pattern should remain relatively similar in PBS. 28 The difference in stiffness of F127-based gels is attributed to the presence of carbamate linkage at the polymer chain ends in F127-BUM ( Figure S1), which can form intermolecular hydrogen bonds. The PGE-DMA hydrogel had a lower storage modulus (96 kPa) largely due to the lower concentration of polymer present.…”

Section: Stability Of Cell-free Hydrogels Under Physiological Conditionsmentioning

confidence: 99%

Physical confinement impacts cellular phenotype within living materials

Priks

Butelmann

Illarionov

et al. 2020

Preprint

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Additive manufacturing allows three-dimensional printing of polymeric materials together with cells, creating living materials for applications in biomedical research and biotechnology. However, understanding the cellular phenotype within living materials is lacking and a key limitation for their wider application. Herein, we present an approach to characterize the cellular phenotype within living materials. We immobilized the budding yeast Saccharomyces cerevisiae in three different photocross-linkable triblock polymeric hydrogels containing F127-bis-urethane methacrylate, F127-dimethacrylate, or poly(alkyl glycidyl ether)-dimethacrylate. Using optical and scanning electron microscopy, we showed that hydrogels based on these polymers were stable under physiological conditions, but yeast colonies showed differences in the interaction within the living materials. We found that the physical confinement, imparted by compositional and structural properties of the hydrogels, impacted the cellular phenotype by reducing the size of cells in living materials compared with suspension cells. These properties also contributed to the differences in immobilization patterns, growth of colonies, and colony coatings. We observed that a composition-dependent degradation of polymers was likely possible by cells residing in the living materials. In conclusion, our investigation highlights the need for a holistic understanding of the cellular response within hydrogels to facilitate the synthesis of application-specific polymers and the design of advanced living materials in the future.

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The effect of physiologically relevant additives on the rheological properties of concentrated Pluronic copolymer gels

Cited by 61 publications

References 23 publications

Photo and thermal properties of cinnamoyl Pluronic F-127

Photo and thermal properties of cinnamoyl Pluronic F-127

Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

Physical confinement impacts cellular phenotype within living materials

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