Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407

The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle

“…Results indicate that by increasing the concentration of P407 in aqueous solutions, the gelation temperature is lowered [24]. The influence of loading P407 gel with ALA or ALA cubosomes on the gelation temperature is a further lowering the CGT.…”

“…If the gelation temperature is higher than 36 o C, the formulation will remain liquid at body temperature, and thus does not control the release of ALA. It would be convenient to have a gelation temperature between 30-36 o C, to be liquid at room temperature, and thus could be spread efficiently on the skin, and form a gel instantly upon contact with the skin [24]. The CGTs of 20 and 30% w/w of P407 solution loaded with ALA or ALA cubosomes compared with P407 placebo solution are shown in Fig.6.…”

Calorimetric and Scattering Studies on Micellization of Pluronics in Aqueous Solutions: Effect of the Size of Hydrophilic PEO End Blocks, Temperature, and Added Salt

“…Similar reductions in the CMT have been observed by Su et al, [61,62] when the effect of salts on the associated behavior of poloxamers was investigated with fluorescence and FTIR. Rehman et al [63] concluded that the NaCl-induced alteration in charge distribution and polarity of the solution. This causes shrinkage of the hydrophobic PPO block below its CMT, that is, presence of salt suppresses micellization.…”

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

“…Studies on PEO-PPO-based polymeric micelles for transdermal drug delivery have been widely carried out with Poloxamer 407 (Pluronic F127) and these studies mostly focused on small drug molecules in order of anti-inflammatory [8][9][10][11][12][13][14][15][16][17][18][19], analgesic [20], local anesthetic [21] and cardiac effectiveness [19,[22][23][24] and rarely focused on big molecules such as arginine vasopressin (AVP) and insulin [25,26].…”

“…In addition, high resolution solid state 1H magic angle spinning nuclear magnetic resonance analyses provided indications of the specific chemical groups in the poloxamer affected by DMSO, and the molecular mechanism involved. The presence of DMSO accelerated dissolution of the pure gel in water and the release of a hydrophobic drug (flufenamic acid) from poloxamer gel, while it reduced the release of a hydrophilic drug (metoprolol tartrate) [19].…”