The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis

Szaefer, Hanna; Kaczmarek, Jolanta; Rybczyńska, Maria; Baer‐Dubowska, Wanda

doi:10.1016/j.tox.2006.10.001

Cited by 29 publications

(17 citation statements)

References 34 publications

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“…Taken together, these results indicate that PCA was able to activate the JNK MAP kinase which in turn had a pivotal role in activating Nrf2 in the macrophage cell line. This finding was in agreement with literature data demonstrating that PCA can activate different signalling kinases in different cell types [52][53][54] and added further convincing evidence 6. PCA enhances the binding of Nrf2 to GPx-ARE and GR-ARE.…”

Section: Discussionsupporting

confidence: 92%

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

Varı̀¹,

D’Archivio²,

Filesi³

et al. 2011

The Journal of Nutritional Biochemistry

150

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Section: Discussionsupporting

confidence: 92%

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

Varı̀¹,

D’Archivio²,

Filesi³

et al. 2011

The Journal of Nutritional Biochemistry

150

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“…Tannic acid (39) was capable of modulating the subcellular distribution of PKC , 1, 2 isoforms and the activity of PKCs [88]. This compound was able to inhibit PKC translocation and activity [88].…”

Section: Tanninsmentioning

confidence: 99%

“…This compound was able to inhibit PKC translocation and activity [88]. Tannic acid (39) was also described to be a potent in vitro inhibitor of EGFR tyrosine kinase [89].…”

Section: Tanninsmentioning

confidence: 99%

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Lamoral-Theys¹,

Pottier

Dufrasne³

et al. 2010

CMC

124

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Over eleven hundred publications reporting anticancer activities of polyphenols have appeared in the peerreviewed literature. In addition, a search of the PubMed database using "polyphenols -cancer -review" as keywords produced over 320 hits for review articles (July 2009). Polyphenol anticancer activities include, among others, anti-oxidative, pro-apoptotic, DNA damaging, anti-angiogenic, and immunostimulatory effects. Targeting specific protein kinases to combat cancer represents a major focus of oncology research within the so-called targeted therapy approach. An exhaustive search of the PubMed database (July 2009) using "polyphenols -cancer -kinases" as keywords resulted in more than 130 hits, half of them having been published within the past five years. Furthermore, the PubMed database contains 25 reviews on the subject of anti-kinase activity of some specific polyphenols, including mainly curcumin and the green tea polyphenol (-)-epigallocatechin 3-gallate (EGCG). However, no attempt has been made yet to review this area of research in a comprehensive, general manner. The current review therefore aims to highlight those anticancer polyphenols that target specific kinases in various types of cancer. The present review also provides an in-depth analysis of polyphenol structure-activity relationships in relation to their anticancer activities and specific kinase targeting. Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases.

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“…From a nutritional point of view, high tannins diets consumption leads to different episodes in humans and animals. Scientific references report evident correlation between dietary polyphenols rich diets and health enhancing properties: antioxidant properties [11][12][13], antibacterial activity on different bacterial strains in vitro and in vivo [7,[14][15][16][17][18][19][20], antiparasitic [21], antiulcerogenic [22][23][24] antidiarrhoic [25], antimutagenic [26][27][28][29][30][31][32][33], antitumor [34][35][36][37][38], and some neoplastic cell line apoptosis [39,40]. On the other hand, high tannins diets might also result in detrimental effects like hepatotoxicity [41,42], toxic nephrosis [43], oesphageal cancer [44], depression of feed intake and growth rate in many animal species [45][46][47][48][49][50][51].…”

Section: Biological Role Of Polyphenolsmentioning

confidence: 99%

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

Cappai¹,

Wolf²,

Pinna³

et al. 2012

FNS

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Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns' tannins content in the diet was positively correlated (R 2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg -1 body weight·d -1 respectively, after one week exposure.

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The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis

Cited by 29 publications

References 34 publications

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Dose-Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs

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