The Effect of Platelet Degranulation on the Formation of Local Inflammatory Process

Solomennikov, A. V.; Tyukavin, A. I.; Арсениев, Н. А.; Chemical, Saint Petersburg State

doi:10.17238/issn2542-1298.2019.7.3.280

Cited by 3 publications

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“…Wound healing is a dynamic and complex process of tissue regeneration and growth that includes four stages ( Figure 1 ) [ 4 ]. The first one is the coagulation and hemostasis that begins from the microvascular bed injury and includes fibrin clot formation, degranulation and aggregation of [ 5 ] thrombocytes (PDGF, VEGF and many others). As a consequence, this leads to involvement of fibroblasts, macrophages and endothelial cells in wound repair [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The first one is the coagulation and hemostasis that begins from the microvascular bed injury and includes fibrin clot formation, degranulation and aggregation of [ 5 ] thrombocytes (PDGF, VEGF and many others). As a consequence, this leads to involvement of fibroblasts, macrophages and endothelial cells in wound repair [ 5 ]. The second, inflammatory stage, is accompanied by infiltration of the wound and its surrounding tissue with inflammatory cells—granulocytes (specifically, fragmented nuclei neutrophils) during the 24–48 h after injury and monocytes 48–72 h after injury.…”

Section: Introductionmentioning

confidence: 99%

“…The final stage is a remodeling which is governed by an equilibrium by tissue matrix metalloproteinase (MMP) proteolytic action and their corresponding tissue inhibitors (TIMPs). During this remodeling stage, the diameter of the collagen fibers increases in addition to a decrease in hyaluronic acid and other glycosaminoglycans content relative to collagen [ 4 , 5 , 6 ]. As a result of the normal wound healing process a dense scar tissue is formed, characterized by an absence of cells and vessels.…”

Section: Introductionmentioning

confidence: 99%

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Modern Wound Dressings: Hydrogel Dressings

et al. 2021

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Chronic wounds do not progress through the wound healing process in a timely manner and are considered a burden for healthcare system; they are also the most common reason for decrease in patient quality of life. Traditional wound dressings e.g., bandages and gauzes, although highly absorbent and effective for dry to mild, exudating wounds, require regular application, which therefore can cause pain upon dressing change. In addition, they have poor adhesional properties and cannot provide enough drainage for the wound. In this regard, the normalization of the healing process in chronic wounds is an extremely urgent task of public health and requires the creation and implementation of affordable dressings for patients with chronic wounds. Modern wound dressings (WDs) are aimed to solve these issues. At the same time, hydrogels, unlike other types of modern WDs (foam, films, hydrocolloids), have positive degradation properties that makes them the perfect choice in applications where a targeted delivery of bioactive substances to the wound is required. This mini review is focused on different types of traditional and modern WDs with an emphasis on hydrogels. Advantages and disadvantages of traditional and modern WDs as well as their applicability to different chronic wounds are elucidated. Furthermore, an effectiveness comparison between hydrogel WDs and the some of the frequently used biotechnologies in the field of regenerative medicine (adipose-derived mesenchymal stem cells (ADMSCs), mesenchymal stem cells, conditioned media, platelet-rich plasma (PRP)) is provided.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modern Wound Dressings: Hydrogel Dressings

et al. 2021

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Additional opportunities for using computer technologies in expert analysis of laboratory data

Solomennikov

Tyukavin

Арсениев

2022

Medicinskij alfavit

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The presented work reflects the author’s algorithm of mathematical processing and possible interpretations of the results obtained when creating expert analytical systems using computer technology. As initial parameters for the construction of neural networks of the second level, it is proposed to use individual results of calculations of the ratios of a number of laboratory indicators capable of forming a single functional cluster (leukogram, indicators of water-electrolyte balance, protein fractions, etc.). Further, using the proposed calculation algorithm and the archive database, structural features in the ′deformation′ of the ratio panel were compared against the background of the growth of each indicator, a matrix table was built reflecting the degree (correlation coefficients, KCr) of the coincidence of the features of the formation of the structure of the obtained panels of the parameters determined in individual observations. At high values of KCr, a conclusion is made about their (determined parameters) unified participation in the mechanism of emerging disorders. Thus, the system allows you to establish a leading complex of associated relationships by changes in the structure of ratios in the selected panel, corresponding to the dynamics of deviation of the target (analyzed) indicator, thereby differentiating the different mechanisms of formation of pathological deviations in this patient, the manifestation and balance of their values in the system-wide response, to evaluate the specific value of the absolute indicator as the final result of such interaction at the time of examination of the patient. The approach used, proposed by the authors, allows us to evaluate not only quantitative relationships, but also the features of the manifestation of the functional properties of the evaluated indicators. All of the above significantly expands the informativeness of the obtained laboratory data, allowing us to build a reasonable paradigm of the connections of the emerging complex of pathological disorders in each individual case. In the list of references, the authors cite publications as concrete examples of the use of the proposed approach in assessing a complex of disorders with different pathological processes using different panels in calculations.

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Latest advance anti-inflammatory hydrogel wound dressings and traditional Lignosus rhinoceros used for wound healing agents

Arbab,

Ullah,

Muhammad

et al. 2024

Front. Bioeng. Biotechnol.

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Wound healing is a physiological process occurring after the onset of a skin lesion aiming to reconstruct the dermal barrier between the external environment and the body. Depending on the nature and duration of the healing process, wounds are classified as acute (e.g., trauma, surgical wounds) and chronic (e.g., diabetic ulcers) wounds. The latter, often affect millions of people globally, take months to heal or not heal non-healing chronic wounds, are typically susceptible to microbial infection, and are a major cause of morbidity. Wounds can be treated with a variety of non-surgical (topical formulations, wound dressings) and surgical (debridement, skin grafts/flaps) methods. Three-dimensional (3D)-(bio) printing and traditional wound dressings are two examples of modern experimental techniques. This review focuses on several types of anti-inflammatory wound dressings, especially focusing on hydrogels and traditional macro-fungi like L. rhinocerotis as agents that promote wound healing. In this study, we introduced novel anti-inflammatory hydrogel dressings and offered innovative methods for application and preparation to aid in the healing. Additionally, we summarize the key elements required for wound healing and discuss our analysis of potential future issues. These findings suggest that L. rhinocerotis and various anti-inflammatory hydrogels can be considered as conventional and alternative macro-fungi for the treatment of non-communicable diseases. We summarized the development of functional hydrogel dressings and traditional Lignosus rhinoceros used for wound healing agents in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

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The Effect of Platelet Degranulation on the Formation of Local Inflammatory Process

Cited by 3 publications

References 0 publications

Modern Wound Dressings: Hydrogel Dressings

Modern Wound Dressings: Hydrogel Dressings

Additional opportunities for using computer technologies in expert analysis of laboratory data

Latest advance anti-inflammatory hydrogel wound dressings and traditional Lignosus rhinoceros used for wound healing agents

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