No abstract

The presented work reflects the author’s algorithm of mathematical processing and possible interpretations of the results obtained when creating expert analytical systems using computer technology. As initial parameters for the construction of neural networks of the second level, it is proposed to use individual results of calculations of the ratios of a number of laboratory indicators capable of forming a single functional cluster (leukogram, indicators of water-electrolyte balance, protein fractions, etc.). Further, using the proposed calculation algorithm and the archive database, structural features in the ′deformation′ of the ratio panel were compared against the background of the growth of each indicator, a matrix table was built reflecting the degree (correlation coefficients, KCr) of the coincidence of the features of the formation of the structure of the obtained panels of the parameters determined in individual observations. At high values of KCr, a conclusion is made about their (determined parameters) unified participation in the mechanism of emerging disorders. Thus, the system allows you to establish a leading complex of associated relationships by changes in the structure of ratios in the selected panel, corresponding to the dynamics of deviation of the target (analyzed) indicator, thereby differentiating the different mechanisms of formation of pathological deviations in this patient, the manifestation and balance of their values in the system-wide response, to evaluate the specific value of the absolute indicator as the final result of such interaction at the time of examination of the patient. The approach used, proposed by the authors, allows us to evaluate not only quantitative relationships, but also the features of the manifestation of the functional properties of the evaluated indicators. All of the above significantly expands the informativeness of the obtained laboratory data, allowing us to build a reasonable paradigm of the connections of the emerging complex of pathological disorders in each individual case. In the list of references, the authors cite publications as concrete examples of the use of the proposed approach in assessing a complex of disorders with different pathological processes using different panels in calculations.

Using the author’s method for determining the multidimensional relationships of ionized calcium in personal observations in 82 patients based on the analysis of the panel of ratios of indicators of water and electrolyte metabolism, it was found that hypercalcemia in the structure of these ratios can include indicators of bone tissue metabolism, while differing in their characteristics. In the discussion, the authors cite modern literary sources that substantiate the established differences in the structure of complexes of multidimensional bonds. Also, the obtained results indicate the possibility of manifestation of signs of changes in the balance of B-cross Laps and TP1N with a high strength in combination with the influence of calcium, while maintaining the absolute values of the latter within the reference values of the norm. The authors believe that in these cases there are signs of a high functional stress of the mechanisms that contribute to maintaining analyte values within the normal range. Summarizing the results of the analysis of the selected observations, the authors believe that the mechanisms involved in the regulation of bone metabolism can be divided into two levels: local and intersystem (in particular, with the participation of leukocyte subpopulations). If the first level (primarily remodeling) weakly correlated with the influence of leukocyte subpopulations on this process, then the second, which was distinguished by significant shifts in the balance of osteosynthesis and osteolysis, included signs of activation of individual leukocyte subpopulations. In conclusion, the authors come to the conclusion that the use of the proposed method of visualizing multidimensional relationships makes it possible to determine the pathogenetic features of the formation of hypercalcemia in individual cases. At the same time, in the presence of a large database on electronic media, the technique for visualizing multidimensional relationships can be proposed as, at least, as an ‘express’ method for ‘recognizing’ different ‘images’ in the structure of the electrolyte ratio panel without actually determining osteomarkers and other complex and expensive methods for the determination of analytes that reflect osteoexchange.