The Effect of Platelet-Rich Plasma on Peyronie’s Disease in Rat Model

Çulha, Mehmet Gökhan; Erkan, Erkan; Çay, Tuğçe; Yücetaş, Uğur

doi:10.1159/000492755

Cited by 19 publications

(6 citation statements)

References 28 publications

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“…Culha et al stated that PRP can produce PDlike plaques in animal models. 42 Our study is the first study showing the formation of PD-like plaque after PRP application in humans. Even though the PD-like plaque formation is small, it leads to discussing the safety of PRP application.…”

Section: Discussionmentioning

confidence: 70%

Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction

Taş

Çakıroğlu²,

Arda

et al. 2021

Sexual Medicine

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Introduction: Platelet-rich plasma (PRP) is useful in the treatment of different conditions and diseases as it contains concentrated levels of many growth factors. Aim: The aim of this study was to investigate the effectiveness of autologous PRP application in the treatment of erectile dysfunction (ED) in patients with metabolic syndrome. Methods: In this prospective study conducted in June 2019, 31 patients with ED were included. The International Index of Erectile FunctioneErectile Function domain (IIEF-EF) questionnaires were used to evaluate erectile function (EF). After administering the intracavernous autologous PRP 3 times with an interval of 15 days, IIEF-EFs were evaluated 1, 3, and 6 months later. Main Outcome Measure: IIEF in the 1st, 3rd, and 6th months and adverse events.Results: While the mean IIEF-EF was 18 before the application, the mean IIEF-EF was 20 in the first, third, and sixth months after the procedure (P < .001). However, even though IIEF-EF values increased numerically, median value remained within the mild-moderate classification (scores between 17 and 21). Postprocedure sexual satisfaction scores were significantly higher than preprocedure values (8 vs 6, respectively; P ¼ .002). In the first follow-up of a patient after the 3rd injection, a 4-mm diameter fibrotic plaque was observed on the ventral side in the middle of the penis shaft. Conclusion:In conclusion, our findings suggest that larger studies as well as placebo-controlled studies are needed to add PRP to the treatment protocol in ED. T Taş, Çakıro glu, E Arda, et al. Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction. Sex Med 2021;9:100313.

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Section: Discussionmentioning

confidence: 70%

Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction

Taş

Çakıroğlu²,

Arda

et al. 2021

Sexual Medicine

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“…It is a concentrate of several growth factors (PDGF, TGF-β, IGF, EGF, VEGF) prepared following centrifugation of the patient’s blood [ 8 ]. The effects of intratunic injection of PRP for the treatment of PD in rats by Culha et al [ 36 ] observed that PRP had no therapeutic effect on PD in the present study assessing the effects of PRP in the Peyronie model created with recombinant TGF-β1 injected into tunica albuginea of the rats.…”

Section: Discussionmentioning

confidence: 70%

Platelet-rich plasma in patients affected with Peyronie’s disease

Chatar

Abdelghani

Jihad

2022

Arab Journal of Urology

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Objectives The objective of our study is to discover and evaluate the effects of repeated intralesional injections inside the tunica albuginea of platelet-rich plasma (PRP) in the treatment of Peyronie’s disease (PD). Methods As part of a prospective study over 12 months from February 2020 until February 2021, on Sixty-five patients with Peyronie’s disease, and penile curvature between 25 and 45°. Patients were stratified into two groups, the first with a curvature between 25 and 35° and the second between 35 and 45°. Gathered data included patient-demographics, Injection technique, outcomes: both quantitative (curvature assessments) and qualitative (state of erectile function, pain during intercourse), and complications. Results Patients in both groups received an average of 6.1 injections of PRP during the study period. Angulation was significantly improved in both groups an average final improvement of 16.88° (SD = 3.35) (p < 0.001) in the first group and 17.27° (SD = 4.22) (p < 0.001) in the second group. Pain during sex decreased from 70.7% to 34.25%, and 55.5% of patients had easier sexual intercourse. Conclusions The positive results of our series of treatment for Peyronie’s disease by injection of platelet-rich plasma are encouraging both methodologically (simplicity) and clinical (safety and efficacy) as well as patient satisfaction.

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“…It has been also shown to reduce the level of inflammatory mediators, while increasing the level of anti‐inflammatory mediators 22,23 . Regenerative and anti‐inflammatory effects of PRP have been demonstrated in various urological diseases such as erectile dysfunction, Peyronie's disease, and urethral stricture 24‐26 . Sekerci et al 11 examined, for the first time, the effect of PRP on I/R damage and hormone production in TT in the literature.…”

Section: Discussionmentioning

confidence: 99%

Effects of platelet‐rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model

et al. 2020

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Background Platelet‐rich plasma is a biological instrument rich in growth factors and cytokines. Objectives The aim of this study was to investigate the effect of platelet‐rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model. Materials and methods The rats were randomly divided into three groups, including six rats in each group as follows: the first group as the sham group; the second group as the ischemia/reperfusion + Saline group and the third group as the ischemia/reperfusion + platelet‐rich plasma group. The left testicles of the ischemia/reperfusion + Saline and ischemia/reperfusion + platelet‐rich plasma group were kept in four‐hour torsion. Then, the left testicles of ischemia/reperfusion + Saline and ischemia/reperfusion + platelet‐rich plasma groups were detorsioned, and intra‐testicular 1 cc saline (ischemia/reperfusion + Saline) and 1 cc platelet‐rich plasma (ischemia/reperfusion + platelet‐rich plasma) were injected. At one month, blood samples were taken from all groups for hormonal evaluation and left orchiectomy was performed. Results The mean follicle‐stimulating hormone level of ischemia/reperfusion + Saline group was significantly higher than ischemia/reperfusion + platelet‐rich plasma group (7.78 ± 0.23 vs 6.18 ± 0.28 nmol/l, respectively, P = .004). The mean LH level of ischemia/reperfusion + platelet‐rich plasma group was significantly lower than ischemia/reperfusion + Saline group (3.63 ± 0.28 vs 5.68 ± 0.21 nmol/l, respectively, P = .004). The mean total testosterone level of ischemia/reperfusion + platelet‐rich plasma group was significantly higher than ischemia/reperfusion + Saline group (8.05 ± 0.24 vs 5.78 ± 0.23 nmol/l, respectively, P = .004). The mean Johnsen scores of ischemia/reperfusion + platelet‐rich plasma group were significantly higher than ischemia/reperfusion + Saline group (5.85 ± 0.58 vs 3.93 ± 0.65, respectively, P = .004). The mean Johnsen score of the sham group was significantly higher than ischemia/reperfusion + platelet‐rich plasma and ischemia/reperfusion + Saline groups (P = .003 and P = .003, respectively). Discussion and conclusion The platelet‐rich plasma has beneficial effects on spermatogenesis and reproductive hormone production in testicular torsion. It is easily accessible and applicable. In the future, intra‐testicular platelet‐rich plasma injection may be used in testicular torsion after detorsion. However, further experimental and large‐scale prospective clinical studies are needed to establish a definitive conclusion on this topic.

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The Effect of Platelet-Rich Plasma on Peyronie’s Disease in Rat Model

Cited by 19 publications

References 28 publications

Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction

Early Clinical Results of the Tolerability, Safety, and Efficacy of Autologous Platelet-Rich Plasma Administration in Erectile Dysfunction

Platelet-rich plasma in patients affected with Peyronie’s disease

Effects of platelet‐rich plasma on spermatogenesis and hormone production in an experimental testicular torsion model

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