The effect of platelet-rich plasma-fibrin glue dressing in combination with oral vitamin E and C for treatment of non-healing diabetic foot ulcers: a randomized, double-blind, parallel-group, clinical trial

Yarahmadi, Amir; Modaghegh, Mohammad-Hadi Saeed; Mostafavi‐Pour, Zohreh; Azarpira, Negar; Mousavian, Alireza; Bonakdaran, Shokoufeh; Jarahi, Lida; Samadi, Alireza; M, Peimani; Alamdari, Daryoush Hamidi

doi:10.1080/14712598.2021.1897100

Cited by 28 publications

(32 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetic foot ulcer (DFU) is a type of DF. Oral vitamin E and C can promote wound healing in patients with nonunion DFU by promoting the wound healing process and reducing oxidative stress [ 112 ]. In addition, studies have shown that paeoniflorin (PF) has the ability to promote DFU wound healing by activating NRF2 related ferroptosis pathway NRF2/HO-1 pathway [ 82 ].…”

Section: Ferroptosis and Ferritinophagy Participate In The Pathogenes...mentioning

confidence: 99%

Ferroptosis and ferritinophagy in diabetes complications

Xia

et al. 2022

Molecular Metabolism

View full text Add to dashboard Cite

Section: Ferroptosis and Ferritinophagy Participate In The Pathogenes...mentioning

confidence: 99%

Ferroptosis and ferritinophagy in diabetes complications

Xia

et al. 2022

Molecular Metabolism

View full text Add to dashboard Cite

“…Three studies involved a total of 233 people receiving treatment for dental extractions [ 15 , 16 , 17 ]. Two studies involved a total of 41 patients receiving treatment for foot ulceration [ 6 , 18 ]. In addition, there was one study that involved 128 patients receiving treatment for dental implants, and one with 10 patients receiving treatment for gingivitis [ 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Yarahmadi et al performed a randomised controlled trial on 25 patients with non-healing foot ulcers. Patients were treated with a platelet-rich plasma-fibrin glue (PRP-FG) dressing plus oral vitamin E and C or PRP-FG dressing plus placebo for eight weeks [ 18 ]. Eight weeks after treatment ulcer size was significantly reduced in both the intervention and control groups ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review on the Role of Vitamin C in Tissue Healing

2022

View full text Add to dashboard Cite

Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between vitamin C supplementation and healing of an acute or chronic condition. Embase, Medline, PubMed, and the Cochrane Library were searched for studies published prior to April 2022. Studies were eligible if they reported at least one association between vitamin C supplementation and healing outcomes. Eighteen studies met the inclusion criteria and were included in this review. Overall, vitamin C supplementation improved healing outcomes in certain pathologies, predominantly pressure ulcers. However, many of the studies had small sample sizes, combined nutritional treatments, and did not test baseline vitamin C. Future studies should be of larger scale, exclusively using vitamin C to determine its role in tissue healing in other wounds. We recommend consideration of vitamin C supplementation for people with pressure ulcers.

show abstract

“…Peripheral neuropathy associated with diabetes is one of the most important reasons for foot ulceration among these patients, finally leading to amputation [2,3]. Diabetic Foot Ulcers (DFU) are one of the leading causes of mortality and morbidity worldwide [4].…”

Section: Vitamin B12 and Risk Of Diabetic Foot Ulcers: A New Paradimementioning

confidence: 99%