The effect of poly(acrylic acid) on temperature‐dependent behaviors and structural evolution of poloxamer 407

Hirun, Namon; Tantishaiyakul, Vimon; Sangfai, Tanatchaporn; Boonlai, Wannisa; Soontaranon, Siriwat; Rugmai, Supagorn

doi:10.1002/pi.6197

Cited by 9 publications

(2 citation statements)

References 53 publications

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“…These mixed micelles have a lower density of coronal chains than neat P407 micelles have. This reduction in chain density favors BCC over FCC, − as occurs when pure PPO or other poloxamers comicellize near P407 micelle cores. ,, Such differences in RP localization can be harnessed to optimize formulations for specific applications. For example, certain formulations require improving drug encapsulation and flux without drastically altering the gel properties or gelation temperature.…”

Section: Resultsmentioning

confidence: 99%

Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition

et al. 2023

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Aqueous solutions of poloxamer 407 (P407), a commercially available and nontoxic ABA triblock polymer (PEO-PPO-PEO), undergo a solution-to-gel transition with increasing temperature and are promising candidates for injectable therapeutics. The gel transition temperature, modulus, and structure are all dictated by polymer concentration, preventing independent tuning of these properties. Here, we show that addition of BAB reverse poloxamers (RPs) to P407-based solutions dramatically alters the gelation temperature, modulus, and morphology. Gelation temperature and RP localization within the hydrogel are dictated by RP solubility. Highly soluble RPs increase gelation temperature and incorporate primarily into the micelle corona regions. Alternatively, RPs with low aqueous solubility decrease gelation temperature and associate within the micelle core and core−corona interface. These differences in RP localization have significant implications for the hydrogel modulus and microstructure. The ability to tune gelation temperature, modulus, and structure through RP addition allows for the design of thermoresponsive materials with specific properties that are unobtainable with neat P407-based hydrogels.

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Section: Resultsmentioning

confidence: 99%

Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition

et al. 2023

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“…The thermal and rheological properties of systems containing PX and poloxamer 188 have previously been assessed in order to alter their phase transition tendencies [13,22]. Moreover, it has been noted that combining PX with polymeric additives such as poly(acrylic acid) and poly(acrylic acid) derivatives might alter the T gel of a gelling vehicle based on PX [23][24][25]. Early studies were particularly concerned with the impact of polymeric additives on the self-assembly and gelation of PX.…”

Section: Introductionmentioning

confidence: 99%

Role of Bovine Serum Albumin Addition in Micellization and Gel Formation of Poloxamer 407

2023

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The combination of the thermoresponsive polymer and protein has demonstrated great promise in its applications in drug delivery and tissue engineering fields. This study described the impact of bovine serum albumin (BSA) on the micellization and sol–gel transition behaviors of poloxamer 407 (PX). The micellization of aqueous PX solutions with and without BSA was examined using isothermal titration calorimetry. In the calorimetric titration curves, the pre-micellar region, the transition concentration region, and the post-micellar region were observed. The presence of BSA had no noticeable impact on critical micellization concentration, but the inclusion of BSA caused the pre-micellar region to expand. In addition to studying the self-organization of PX at a particular temperature, the temperature-induced micellization and gelation of PX were also explored using differential scanning calorimetry and rheology. The incorporation of BSA had no discernible effect on critical micellization temperature (CMT), but it did affect gelation temperature (Tgel) and gel integrity of PX-based systems. The response surface approach illustrated the linear relation between the compositions and the CMT. The major factor affecting the CMT of the mixtures was the concentration of PX. The alteration of the Tgel and the gel integrity were discovered to be a consequence of the intricate interaction between PX and BSA. BSA mitigated the inter-micellar entanglements. Hence, the addition of BSA demonstrated a modulating influence on Tgel and a softening effect on gel integrity. Understanding the influence of serum albumin on the self-assembly and gelation of PX will enable the creation of thermoresponsive drug delivery and tissue engineering systems with controlled gelation temperatures and gel strength.

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Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis

2021

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The effect of poly(acrylic acid) on temperature‐dependent behaviors and structural evolution of poloxamer 407

Cited by 9 publications

References 53 publications

Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition

Engineering the Structure and Rheological Properties of P407 Hydrogels via Reverse Poloxamer Addition

Role of Bovine Serum Albumin Addition in Micellization and Gel Formation of Poloxamer 407

Micellization and gelation characteristics of different blends of pluronic F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis

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