The Effect of Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors on Biochemical Changes in Testicular Ischemia-Reperfusion Injury

Bozlu, Murat; Eskandari, Gülçin; Çayan, Selahíttín; Canpolat, Bülent; Akbay, Erdem; Atik, Uğur

doi:10.1097/01.ju.0000049228.37887.4d

Cited by 37 publications

(33 citation statements)

References 18 publications

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“…14 Bozlu et al showed that IR injury elevated NO production in a model of testicular torsion and detorsion in rat. 15 Also, results in previous studies suggest that NO has an important role in damaging the testis via IR injury. 40 Similarly our study showed that IR injury due to testicular torsion and detorsion elevated NO production in a rat model.…”

Section: Discussionmentioning

confidence: 99%

“…6 Lots of chemicals, drugs and physical methods such as intratesticular testosterone, biocompatible surfactant (tetronic 1107), allopurinol, vitamin E, NG-nitro-Larginine methyl ester (a precursor of NO), polyethylene glycol-superoxide dismutase, immunosuppression with cyclosporinee and prednisone, caffeic acid phenethyl ester, poly (ADP-ribose) polymerase inhibitors, pentoxifylline, vasoactive intestinal polypeptide, zinc aspartate, melatonin, hyperbaric oxygen therapy and chemical sympathectomy have been used to prevent IR injury in testicular torsion and detorsion. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] These products were found to be effective in preventing testicular damage. Trapidil has not been used in testicular IR injury previously.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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Objective: We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion. Methods: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose 1 h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. Results: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P < 0.05, P < 0.001 and P < 0.001, respectively). A statistical difference was not found among study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P > 0.05). The T-SH level in the study group was significantly higher than in the IR, sham and sham plus trapidil groups in left testis P < 0.05). In the IR group (left testis), grade 1 interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade 1 interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). Conclusion: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Somuncu¹,

Çakmak²,

Erdoğan³

et al. 2006

Int J of Urology

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“…It is well documented that neutrophils recruited to the testis after torsion are potent generators of ROS. Several studies indicate that neutrophils are recruited to the testis as early as 4 h after I/R [26,28] . In the present study, MPO showed an increase in testicular tissue 4 h after I/R, but the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Thymoquinone in Experimental Testicular Torsion

Gökçe¹,

Oktar²,

Köç³

et al. 2010

Urol Int

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Objectives: To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. Materials and Methods: Experiments were performed on male C57BL/6 mice (8 weeks old, 20–25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), torsion/detorsion (TD) and TD+TQ. Mice, except the sham-operated group, were subjected to left unilateral torsion (720° rotation in the clockwise direction). The experiments were finished after sham operation time for controls, 120 min torsion and 240 min detorsion for the other groups. In the TD+TQ group 10 mg TQ was injected intraperitoneally 30 min before detorsion. Results: In the TD group total oxidative stress (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were higher than in the controls. TQ treatment decreased MDA, TOS and OSI values, but did not affect the total antioxidant capacity and myeloperoxidase activity in the TD+TQ group. Upon histological examination, mice in the TD group displayed moderate-to-severe disruption of the seminiferous epithelium. Treatment with TQ resulted in significantly reduced histological damage associated with I/R injury. Conclusion: Our results suggested that TQ treatment may have a protective effect on testicular I/R injury.

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“…The testicular damage due to torsion and detorsion (T/D) shares resemblance with the phenomenon of ischemia-reperfusion (I/R) injury observed in other tissues [3]. A possible cause of the testicular injury due to torsion and detorsion is an I/R injury attributed to neutrophil infiltration and oxygen free radicals [4]. Several enzymes and drugs, such as melatonine, vitamins E and C, surfactane, and hyperbaric oxygen therapy, have been studied to prevent such injury in testis [5].…”

Section: Introductionmentioning

confidence: 97%

The protective effect of erythropoietin infusion on testicular torsion/detorsion: an experimental study

et al. 2008

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The Effect of Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors on Biochemical Changes in Testicular Ischemia-Reperfusion Injury

Abstract: These data emphasize that poly (ADP-ribose) polymerase may have a role in testicular damage caused by ischemia-reperfusion and the inhibition of poly (ADP-ribose) polymerase may be a novel approach to therapy for ischemia-reperfusion injury of the testis.

Cited by 37 publications

References 18 publications

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Protective effects of trapidil in ischemia–reperfusion injury due to testicular torsion and detorsion: An experimental study

Protective Effect of Thymoquinone in Experimental Testicular Torsion

The protective effect of erythropoietin infusion on testicular torsion/detorsion: an experimental study

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