The present work aims to study the effect of nano-particles volume fraction of nano-fluid on the heat transfer during pool boiling with different values of heat flux. The concentration ratios by volume in demineralized water are taken as 0.02 %, 0.20 %, 0.40 %, 0.60, and 0.80 % for Al2O3 nano-particles and 0.02 %, 0.06 %, and 0.20 % for CuO nano-particles. Heat transfer coefficients for pool boiling were established experimentally for different values of volume fraction and heat flux. The heating element is made from an aluminum alloy (AL 6061) with a circular smooth surface of 100 mm diameter and 10 mm thickness. The nano-particles porous layer that builds up during boiling is observed by a scanning electron microscope of the heated surface before and after the boiling. The results demonstrate that the heat transfer rate depends on the concentration ratios and heat flux. Using nano-particles decreases the pool boiling heat transfer in comparison with demineralized water. Due to the deposition of nano-particles on the heated surface, lower heat transfer is obtained for a lower bubble departure compared with demineralized water for the small wall superheat.