The effect of probiotics and their metabolic products on cardiovascular system cells in vitro

Sobol, K. V.; Belostotskaya, G. B.; Нестеров, В. П.

doi:10.1134/s0012496611010091

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Lam et al (30) demonstrated that the oral administration of the commercially available probiotic juice (L. plantarum 299v) reduced myocardial infarct size in Dahl S rats. Sobol et al (31) considered that LAB and their metabolic products in particular may positively affect the calcium signal in cells in the cardiovascular system, which may result in increased contractile activity of blood vessels and cardiac cells. Based on previous findings, we hypothesized that anthocyanidin-enriched purple potato and the probiotics in PSPY may also be the components that potentially contribute to the activation of the PI3K/AKT survival pathway and the attenuation of cardiac apoptosis, and account for the insignificant difference between the 2 PSPY dosages.…”

Section: Discussionmentioning

confidence: 99%

Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats

Lin

Hsieh

Kuo

et al. 2013

International Journal of Molecular Medicine

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Apoptosis is recognized as a predictor of adverse outcomes in subjects with cardiac diseases. The aim of this study was to explore the effects of probiotic-fermented purple sweet potato yogurt (PSPY) with high γ-aminobutyric acid (GABA) content on cardiac apoptosis in spontaneously hypertensive rat (SHR) hearts. The rats were orally adminsitered with 2 different concentrations of PSPY (10 and 100%) or captopril, 15.6 mg/kg, body weight (BW)/day. The control group was administered distilled water. DAPI and TUNEL staining were used to detect the numbers of apoptotic cells. A decrease in the number of TUNEL-positive cardiac myocytes was observed in the SHR-PSPY (10 and 100%) groups. In addition, the levels of key components of the Fas receptor- and mitochondrial-dependent apoptotic pathways were determined by western blot analysis. The results revealed that the levels of the key components of the Fas receptor- and mitochondrial-dependent apoptotic pathway were significantly decreased in the SHR-captopril, and 10 and 100% PSPY groups. Additionally, the levels of phosphorylated insulin-like growth factor‑I receptor (p-IGF‑IR) were increased in SHR hearts from the SHR-control group; however, no recovery in the levels of downstream signaling components was observed. In addition, the levels of components of the compensatory IGF-IR-dependent survival pathway (p-PI3K and p-Akt) were all highly enhanced in the left ventricles in the hearts form the SHR-10 and 100% PSPY groups. Therefore, the oral administration of PSPY may attenuate cardiomyocyte apoptosis in SHR hearts by activating IGF‑IR-dependent survival signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats

Lin

Hsieh

Kuo

et al. 2013

International Journal of Molecular Medicine

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“…Toral et al (42) demonstrated an endothelial-protective effect of L. coryniformis CECT5711 in obese mice through increased nitric oxide bioavailability. Sobol et al (43) considered that lactic acid bacteria, and their metabolic products in particular, may positively affect calcium signalling in cardiovascular cells, resulting in increased contractile activity of blood vessels and cardiac cells. However, the present limited findings suggest that probiotics may directly reduce cardiac apoptosis in rats fed a high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

Effects of lactic acid bacteria on cardiac apoptosis are mediated by activation of the phosphatidylinositol-3 kinase/AKT survival-signalling pathway in rats fed a high-fat diet

Wang

Lin

Chen

et al. 2014

International Journal of Molecular Medicine

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Through a high-fat diet, obesity leads to cardiomyocyte dysfunction and apoptosis. In addition, there is no evidence that probiotics have potential health effects associated with cardiac apoptosis in obese rats. The present study aimed to explore the effects of probiotics on obesity and cardiac apoptosis in rats fed a high-fat diet (HF). Eight‑week‑old male Wistar rats were separated randomly into five equally sized experimental groups: Normal diet (NC) and high-fat diet (HFC) groups, and high-fat diet supplemented with low (HFL), medium (HFM) or high (HFH) doses of multi‑strain probiotics groups. The rats were subsequently studied for 8 weeks. Food intake and body weights were recorded following sacrifice, and food utilization rates, body fat and serum cholesterol levels were analysed. The myocardial architecture of the left ventricle was evaluated by hematoxylin‑eosin staining, and key apoptotic‑related pathway molecules were analysed by western blotting. Rat weights and triglyceride levels were decreased with oral administration of high doses of probiotics (HFH) compared to the HFC group. Abnormal myocardial architecture and enlarged interstitial spaces were observed in HFC hearts, but were significantly decreased in groups that were provided multi‑strain probiotics compared with NC hearts. Western blot analysis demonstrated that key components of the Fas receptor‑ and mitochondrial‑dependent apoptotic pathways were significantly suppressed in multi‑strain probiotic treated groups compared to the HF group. Additionally, cardiac insulin, such as the insulin‑like growth factor I receptor (IGFIR)‑dependent survival signalling components, were highly induced in left ventricles from rats administered probiotics. Together, these findings strongly suggest that oral administration of probiotics may attenuate cardiomyocyte apoptosis by activation of the phosphatidylinositol‑3 kinase/AKT survival‑signalling pathway in obese rats.

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A New Class of Pharmabiotics With Unique Properties

Sobol

2017

Soft Chemistry and Food Fermentation

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The effect of probiotics and their metabolic products on cardiovascular system cells in vitro

Cited by 4 publications

References 12 publications

Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats

Probiotic-fermented purple sweet potato yogurt activates compensatory IGF-IR/PI3K/Akt survival pathways and attenuates cardiac apoptosis in the hearts of spontaneously hypertensive rats

Effects of lactic acid bacteria on cardiac apoptosis are mediated by activation of the phosphatidylinositol-3 kinase/AKT survival-signalling pathway in rats fed a high-fat diet

A New Class of Pharmabiotics With Unique Properties

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