The Effect of Probiotics on Reducing Duration of Hospitalization in Infants with Indirect Hyperbilirubinemia

Hamed, Amira Mohammed Mohammed; Abdelmeguid, Mona; Omar, Shehab Ahmed Abdel Maksoud

doi:10.21608/ejhm.2019.64968

Cited by 4 publications

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“…18 Hamed et al also concluded that the addition of probiotics significantly decreased the serum total bilirubin levels and the time required for phototherapy. 19 A study conducted in Iran also showed that probiotics can reduce the serum total bilirubin levels when used as an adjunct to standard therapy. 20 A meta-analysis conducted by Chen Z et al provided evidence that the combination of routine treatment with probiotics including Bifidobacterium, S. boulardii, C. butyricum, probiotic oligosaccharides and B. subtilis had more efficacy in neonatal jaundice.…”

Section: Resultsmentioning

confidence: 99%

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

Afzal

Butt

Munir

et al. 2021

Ann Pak Inst Med Sci

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Objective: To compare the mean change in the bilirubin levels with addition of probiotics to standard treatment for the management of neonatal jaundice. Methodology: The randomized controlled trial was undertaken at the Neonatal Intensive Care Unit of the Paediatrics Department, Federal Government Polyclinic (Post Graduate Medical Institute), Islamabad from 1st April to 30th September 2019. Neonates with hyperbilirubinemia requiring phototherapy were randomly divided into two groups, each having 30 patients. Group A received probiotics along with phototherapy while group B received phototherapy alone. Primary outcome was serum total bilirubin, which was calculated on 0, 1 and 3 days of treatment. Duration of phototherapy and patient's outcome was also recorded. Data was analyzed statistically using SPSS v. 23. Results: The mean serum bilirubin level after 24 hours was 14.27 ± 4.35 mg/dl in combination group while 16.43 ± 4.36 mg/dl in phototherapy group (p > 0.05). After 48 hours, the mean serum bilirubin level was 12.37 ± 3.33 mg/dl in combination group while 14.09 ± 3.60 mg/dl in phototherapy group (p > 0.05). After 72 hours, the mean serum bilirubin level was 11.09 ± 2.87 mg/dl in combination group while 11.72 ± 2.96 mg/dl in phototherapy group (p > 0.05). The mean time required of blue light phototherapy was 43.47 ± 20.71 hours in combination group while 61.53 ±28.27 hours in phototherapy group (p < 0.05). All neonates were discharged. Conclusion: Addition of probiotics to standard treatment decreased the time required for the phototherapy in neonatal jaundice. However no statistically significant difference was seen in the bilirubin levels between the two groups.

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Section: Resultsmentioning

confidence: 99%

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

Afzal

Butt

Munir

et al. 2021

Ann Pak Inst Med Sci

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Section: Bahasanunclassified

“…Hal yang sejalan juga ditunjukkan oleh Hamed et al 14 pada penelitiannya terhadap 100 bayi term dengan penyakit kuning yang dirawat di rumah sakit untuk fototerapi. Hamed et al 14 menggunakan metode penelitian RCT dimana kedua kelompok menerima fototerapi dan kelompok intervensi menerima 10 ml formula sachet yang mengandung probiotik. Hasil penelitian tersebut membuktikan bahwa kelompok intervensi dapat menurunkan level bilirubin secara bermakna pada hari pertama (p=0,003), keempat (p=0,001), dan kelima (p=0,001) setelah pengobatan.…”

Section: Bahasanunclassified

Pengaruh Pemberian Probiotik terhadap Neonatus dengan Hiperbilirubinemia

Hastuti

Rompis

Manoppo

2023

MSJ

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Hyperbilirubinemia is a medical condition that is often found in the first week of neonates. The usual treatment for hyperbilirubinemia is phototherapy, however, many studies revealed probiotics as another form of treatment. Probiotics are live microorganisms that have similarities to the normal intestinal flora. They are believed to reduce enterohepatic cycle activity which can reduce serum bilirubin in neonates with hyperbilirubinemia. This study aimed to determine the effect of probiotics on neonates with hyperbilirubinemia. This was a literature review study using three different databases, namely Pubmed, Google Scholar, and ClinicalKey. The results obtained 10 literatures carried out from related inclusion and exclusion selections. After reviewing the ten literatures, it was found that the most widely used probiotic genus was Lactobacillus where the strain that had the greatest influence was Lactobacillus reuteri. Six out of ten literatures stated that probiotics had significant effect as a treatment for neonates with hyperbilirubinemia due to their capability to reduce the total serum bilirubin. In conclusion, probiotics may affect the treatment of neonates with hyperbilirubinemia. Keywords: probiotics; hyperbilirubinemia; neonates Abstrak: Hiperbilirubinemia merupakan salah satu kondisi medis yang sering dijumpai pada seminggu pertama pada neonatus. Pengobatan yang biasa diberikan pada hiperbilirubinemia ialah fototerapi, namun saat ini telah banyak penelitian mengenai probiotik sebagai bentuk pengobatan lainnya. Probiotik merupakan mikroorganisme hidup yang memiliki kesamaan dengan flora normal usus dan dipercaya dapat menurunkan aktivitas siklus enterohepatik dan selanjutnya bilirubin serum pada neonatus yang mengalami hiperbilirubinemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian probiotik pada neonatus dengan hiperbilirubinemia. Jenis penelitian ialaah suatu literature review berdasarkan pencarian melalui tiga database yaitu Pubmed, Google Scholar, dan ClinicalKey. Hasil penelitian mendapatkan 10 literatur yang telah dilakukan seleksi kriteria inklusi dan eksklusi terkait. Dari 10 jurnal yang telah diulas, didapatkan bahwa genus probiotik yang paling banyak digunakan ialah Lactobacillus, dan strain yang memiliki pengaruh terbesar yaitu Lactobacillus reuteri. Enam dari 10 literatur menyatakan bahwa pemberian probiotik dapat berpengaruh bermakna sebagai pengobatan neonatus dengan hiperbilirubinemia karena probiotik dapat membantu menurunkan nilai total serum bilirirubin. Simpulan penelitian ini ialah probiotik dapat memengaruhi pengobatan neonatus dengan hiperbilirubinemia. Kata kunci: probiotik; hiperbilirubinemia; neonatus

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“…The prognosis of PrNJ is good in more than 90% of the suceas, depending on timely diagnosis and underlying pathology [8]. Almost all children with PrNJ recover without complications by the age of 8 weeks [9]. Clinical experience proves that annual seasons influence the occurrence and severity of neonatal HB.…”

Section: Introductionmentioning

confidence: 99%

Climatic factors and prolonged neonatal jaundice

Tatyana ITOVA

2023

World J. Bio. Pharm. Health Sci.

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Prolonged neonatal jaundice (PrNJ) in full-term newborns(NB) is defined if it persists beyond the 14th day after birth. Clinical experience shows that seasons of the year influence the frequency and severity of neonatal jaundice (NJ). Objective: To establish the role of climatic factors on PrNJ expression in term neonates. Material and methods: The study was conducted at the Neonatology Department of University Hospital "Medica Ruse" with 92 full-term newborns who were with PrNJ. The follow-up of NJ was carried out with transcutaneous bilirubinometry. The NBs are residents of Ruse region, Republic of Bulgaria. Results: We found that air temperature directly affects the levels of bilirubin(BR) for the entire neonatal period and the duration of PrNJ. The amount of rainfall during the first two weeks after birth directly correlated with bilirubinemia at end of neonatal period and the duration of PrNJ. A higher level of atmospheric pressure during the early neonatal period was associated with lower BR levels at the same and a shorter duration of PrNJ. The degree of cloudiness after postnatal day 14 is inversely related to the levels of BR and the duration of the PrNJ. Sunshine during the first two weeks affects the levels of BR on the end of neonatal perod and the prolongation of PrNJ. Conclusion: According to our data climatic factors: air temperature, amount of rainfaull, atmospheric pressure, degree of cloudiness, duration of sunshine affect the degree of manifestation and duration of PrNJ.

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The Effect of Probiotics on Reducing Duration of Hospitalization in Infants with Indirect Hyperbilirubinemia

Cited by 4 publications

References 0 publications

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

Effect of Addition of Probiotics to Standard Treatment on Neonatal Jaundice

Pengaruh Pemberian Probiotik terhadap Neonatus dengan Hiperbilirubinemia

Climatic factors and prolonged neonatal jaundice

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