The Effect of Prostaglandin F2  on the Progestogen Content of Ovaries from Pseudopregnant Rats

Pharriss, Bruce B.; Wyngarden, Lillian J.

doi:10.3181/00379727-130-33495

Cited by 225 publications

(67 citation statements)

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“…Evidence was subsequently provided in rats that treatment with PGF2α produced luteolysis (Gutknecht et al, 1969;Pharriss and Wyngarde 1969). Thereafter, a series of experiments by McCracken using auto-transplanted ovaries demonstrated the luteolytic effect of PGF in sheep (Goding et al, 1967;McCracken, 1971).…”

Section: Period Ii: Normal Luteolysis: Role Of Uterus and Pgf -Days 1mentioning

confidence: 99%

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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In ruminants, there are specific times during the estrous cycle or pregnancy when the corpus luteum (CL) may undergo regression. This review has attempted to summarize the physiological and cellular mechanisms involved in CL regression or maintenance during four distinct periods. The first period is near day 7 when animals that are ovulating after a period of low circulating progesterone (P4), such as first pubertal ovulation or first postpartum ovulation, are at risk of having a premature increase in Prostaglandin F2α (PGF) secreted from the uterus resulting in early CL regression and a short estrous cycle. The second period is when normal luteolysis occurs at day 18-25 of the cycle or when the CL is rescued by interferon-tau secreted by the elongating embryo. The uterine mechanisms that determine the timing of this luteolysis or the prevention of luteolysis have been generally defined. Induction and activation of endometrial E2 receptors result in induction of endometrial oxytocin receptors that can now be activated by normal pulses of oxytocin. Of particular importance is the observation that the primary mechanisms are only activated through local (ipsilateral) and not a systemic route due to transfer of PGF from the uterine vein to the ovarian artery. In addition at the CL level, studies are providing definition to the cellular and molecular mechanisms that are activated in response to uterine PGF pulses or pregnancy. The third period that is discussed occurs in the second month of pregnancy (day 28-60) when undefined mechanisms result in CL maintenance of an ipsilateral CL but regression of a contralateral (opposite side from pregnancy) CL. The final period that is discussed is regression of the CL just prior to parturition. Although, cortisol from the fetus appears to be the primary initiator of luteolysis, PGF seems to be the final signal that causes regression of the CL. Thus, in all four periods, regression of the CL is likely to be caused by the direct actions of PGF that is secreted from the uterus. The uterine mechanisms that result in secretion of PGF seem to be normally inhibited during the early luteal phase, making short luteal phases not a normal event, and are altered during early pregnancy (day 18-25) resulting in prevention of luteolysis. During much of pregnancy, the mechanisms that cause PGF secretion from the uterus in response to oxytocin are intact but luteolysis does not normally occur, perhaps due to lack of efficient utero-ovarian transfer of PGF.

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Section: Period Ii: Normal Luteolysis: Role Of Uterus and Pgf -Days 1mentioning

confidence: 99%

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Wiltbank¹,

Meidan²,

Ochoa³

et al. 2016

Anim Reprod

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“…The luteolytic action of prostaglandin (PG) F-2a in the rat was first demonstrated by Pharriss & Wyngarden (1969), who reported the increase in 20a-dihydroprogesterone concentrations that follow PG treatment. Subsequently, several hypotheses were proposed for the mechanism of action of PGF-2a (reviewed .…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin F-2 receptors in corpora lutea of pregnant rats and relationship with induction of 20 -hydroxysteroid dehydrogenase

Bussmann¹

1989

Reproduction

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“…Pharriss and Wyngarden first postulated that prostaglandin F, was responsible for this phenomenon [3] and subsequent experiments have shown that this prostaglandin is luteolytic in several animals [2]. Conclusive evidence was recently presented that prostaglandin F,, is a luteolytic hormone in the sheep [4]; it was released in relatively high concentrations from the uterus a t the time of luteal regression and was transferred from the utero-ovarian vein to the ovarian artery by a counter-current mechanism [4].…”

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confidence: 99%

Prostaglandin F_2α Receptor in Ovine corpora lutea

Powell

Hammarström

Samuelsson

1974

European Journal of Biochemistry

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Evidence is presented for the existence of a prostaglandin-F, receptor in ovine corpora lutea. Prostaglandin F,, was specifically bound to a particulate fraction of this tissue with a dissociation constant of 0.1 pM. Prostaglandins F1,, E, and E, had considerably less affinity for the receptor whereas prostaglandins A, and B, had little or no affinity. From a comparison of the binding constants of various prostaglandins and related compounds it could be concluded that the carboxyl group, the three hydroxyl groups and the 5,6-cis double bond (but not the 13,14-trans double bond) of prostaglandin F,, were all important for binding to the receptor.The uterus is required for normal cyclic regression of corpora lutea in a number of mammalian species [l, 21. Pharriss and Wyngarden first postulated that prostaglandin F, was responsible for this phenomenon [3] and subsequent experiments have shown that this prostaglandin is luteolytic in several animals [2]. Conclusive evidence was recently presented that prostaglandin F,, is a luteolytic hormone in the sheep [4]; it was released in relatively high concentrations from the uterus a t the time of luteal regression and was transferred from the utero-ovarian vein to the ovarian artery by a counter-current mechanism [4].The mechanism of the luteolytic effect of prostaglandin F,, is unknown. It has been proposed that prostaglandin F,, acts luteolytically by restricting the blood flow through the ovary[3], but subsequent experiments [5,6] have not substantiated this hypothesis. Prostaglandin F,, has been found to depress cholesterol ester synthetase activity in rat ovaries and it was suggested [7] that this might be the mechanism for the reduction in progesterone synthesis caused by prostaglandin F, in vivo [Z-41. I n bovine corpora latea slices prostaglandins E,, E,, F,, and A, (decreasing order of effectiveness) stimulated rather than inhibited Abbreviation. Me,Si, trimethylsilyl. Trivial Names. Prostaglandin F,,, 9a,llor,l5(S)-trihydroxyprost-l3-trans-enoic acid; prostaglandin FZa, 9a,l la, 15(S)-trihydroxyprosta-5-cis,13-truns-dienoic acid; prostaglandin F,b, 9~,11~-15(5)-trihydroxyprosta-5-cis,l3-trun~-dienoic acid ; prostaglandin El, 11 a, 15-(S)-dihydroxy-9-ketoprost-13-trans-enoic acid; prostaglandin E,, lla,15(S)-dihydroxy-9-ketoprosta-5-cis,13-truns-dienoic acid; prostaglandin A,, 15(S)-hydroxy-9-ketoprosta-10,13-trans-dienoic acid; prostaglandin A,, 15(S)-hydroxy-9-ketoprosta-5-cis,-10,13-trans-trienoio acid; prostaglandin B,, 15(S)-hydroxy-9-ketoprosta-5-cis,S( 12),13-trans-trienoic acid.

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The Effect of Prostaglandin F2 on the Progestogen Content of Ovaries from Pseudopregnant Rats

Cited by 225 publications

References 0 publications

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Prostaglandin F-2 receptors in corpora lutea of pregnant rats and relationship with induction of 20 -hydroxysteroid dehydrogenase

Prostaglandin F_2α Receptor in Ovine corpora lutea

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The Effect of Prostaglandin F2 on the Progestogen Content of Ovaries from Pseudopregnant Rats

Cited by 225 publications

References 0 publications

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Maintenance or regression of the corpus luteum during multiple decisive periods of bovinepregnancy

Prostaglandin F-2 receptors in corpora lutea of pregnant rats and relationship with induction of 20 -hydroxysteroid dehydrogenase

Prostaglandin F2α Receptor in Ovine corpora lutea

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Prostaglandin F_2α Receptor in Ovine corpora lutea