The significant importance of entrepreneurship for the economic development, job creation and innovation have increased the concerns of researchers and decision makers at different levels for the understanding and investigation of the factors that could have an impact on the level of entrepreneurial activity. In fact, differences in entrepreneurial activity and entrepreneurship are substantial, persistent and distinct from their background in different nations and / or regions, especially in Europe. Theoretical studies and empirical studies confirm that the entrepreneurial activities of individuals are the main drivers of the development of entrepreneurship, namely in terms of economic growth, mainly through the contribution to the creation of new jobs, the development of competitiveness and innovations at the enterprise.For this purpose, we used two Global Databases Entrepreneurship Monitor (GEM) of the year 2015, which were duly adapted and thus created the database for the analysis of this study, having as justification performed literature review considered the variables necessary for this purpose.Results reveal that the key determinants of the entrepreneurial intention in the European countries are: "perceived capacity" by the individual; the "entrepreneurial intention" itself which will, in fact, influence the "rate of nascent entrepreneurship"; the "governmental and political factors" in relation to the respective "financing for the entrepreneur", and the "basic education and training" in entrepreneurship which influence "research & development".