The Effect of Pulsing Electromagnetic Fields on Bone Metabolism in Experimental Disuse Osteoporosis

Cruess, Richard L.; Kan, Kenneth W.; Bassett, C. A. L.

doi:10.1097/00003086-198303000-00034

Cited by 50 publications

(17 citation statements)

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“…Other studies carried out by Cruess et al [1983], McLeod and Rubin [1990Rubin [ , 1992, and Simske et al [1991] had the same experimental results of bone loss inhibition by PEMF.…”

Section: Introductionsupporting

confidence: 60%

“…Bassett et al [1979] and Cruess et al [1983] found that their single pulses (frequency of 72 Hz, pulse width of 380 ms and induced electric field intensity of 1.5 mV/cm) were as effective as pulse bursts in preventing disuse osteoporosis in rats. In their study, fields were applied by means of whole-body coils for 24 h/day.…”

Section: Discussionmentioning

confidence: 99%

“…In their study, fields were applied by means of whole-body coils for 24 h/day. Tabrah et al [1990Tabrah et al [ , 1998 reported that the same PEMF used by Bassett et al [Bassett et al, 1979;Cruess et al, 1983] had the capability to prevent bone loss in osteoporosis prone women. Mishima [1988] found pulse burst waves at a positive amplitude of 25 mV, burst width of 4.2 ms, pulse width of 230 ms, and repetition rate of 12 Hz to be effective in preventing osteoporosis caused by bilateral ovariectomy and right sciatic neurectomy in rats.…”

Section: Discussionmentioning

confidence: 99%

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Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process

Chang

2003

Bioelectromagnetics

112

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With the use of Helmholtz coils and pulsed electromagnetic field (PEMF) stimulators to generate uniform time varying electromagnetic fields, the effects of extremely low frequency electromagnetic fields on osteoporosis and serum prostaglandin E(2) (PGE(2)) concentration were investigated in bilaterally ovariectomized rats. Thirty-five 3 month old female Sprague-Dawley rats were randomly divided into five different groups: intact (INT), ovariectomy (OVX), aspirin treated (ASP), PEMF stimulation (PEMF + OVX), and PEMF stimulation with aspirin (PEMF + ASP) groups. All rats were subjected to bilateral ovariectomy except those in INT group. Histomorphometric analyses showed that PEMF stimulation augmented and restored proximal tibial metaphyseal trabecular bone mass (increased hard tissue percentage, bone volume percentage, and trabecular number) and architecture (increased trabecular perimeter, trabecular thickness, and decreased trabecular separation) in both PEMF + OVX and PEMF + ASP. Trabecular bone mass of PEMF + OVX rats after PEMF stimulation for 30 days was restored to levels of age matched INT rats. PEMF exposure also attenuated the higher serum PGE(2) concentrations of OVX rats and restored it to levels of INT rats. These experiments demonstrated that extremely low intensity, low frequency, single pulse electromagnetic fields significantly suppressed the trabecular bone loss and restored the trabecular bone structure in bilateral ovariectomized rats. We, therefore, conclude that PEMF may be useful in the prevention of osteoporosis resulting from ovariectomy and that PGE(2) might relate to these preventive effects.

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“…Other studies carried out by Cruess et al [1983], McLeod and Rubin [1990Rubin [ , 1992, and Simske et al [1991] had the same experimental results of bone loss inhibition by PEMF.…”

Section: Introductionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process

Chang

2003

Bioelectromagnetics

112

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“…A related model, sciatic neurectomy, and the more invasive tendonectomy of all distal calf tendons, produce osteoporotic conditions [4,7,9]. However, sciatic nerve crush has been shown to induce similar osteoporotic conditions in a less invasive manner, having less gross body disuse PSI.…”

Section: Introductionmentioning

confidence: 99%

Osteoprotegerin ameliorates sciatic nerve crush induced bone loss

Bateman

Dunstan

Ferguson

et al. 2001

Journal Orthopaedic Research

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This study examines the ability of osteoprotegerin (OPG) to prevent the local bone resorption caused by sciatic nerve damage. Sixty-five 18-week-old male mice were assigned to one of six groups (n = 10-1 llgroup). A baseline control group was sacrificed on day zero of the 10-day study. The remaining groups were placebo sham operated, placebo nerve crush (Plac NC) operated, 0.1 mglkglday OPG + nerve crush (LOW), 0.3 mg/kg/day OPG + nerve crush (MED), and 1 .O mg/kg/day OPG + nerve crush (HI).Nerve crush or sham operations were performed on the right leg. The left leg served as a contralateral control to the nerve crushed (ipsilateral) leg. The difference in mass between the right and left femur and tibia was examined. Additionally, quantitative histomorphometry was performed on the right and left femur and tibia diaphyses. Nerve crush resulted in a significant loss of bone mass in the ipsilateral side compared to the contralateral side. Bone mass for the ipsilateral bones of the Plac NC group were significantly reduced by 3.8% in the femur and 3.5% in the tibia compared to the contralateral limb. The percent diminution was reduced for OPG treated mice compared to the Plac NC group for both the femur and tibia. In the femur, the percent reduction of ipsilateral bone mass was reduced to 1.0% (LOW), 1.3% (MED) and 1.6% (HI) compared to the contralateral limb. In the tibia, loss of bone mass in the ipsilateral limb was reduced to 1.4% (LOW), 1.4% (MED), and 2.4% (HI) compared to the contralateral. OPG also decreased the amount of tibial endocortical resorption compared to the Plac NC group. In summary, OPG mitigated bone loss caused by damage to the sciatic nerve.

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“…Recently, demonstrated that PEMF inhibits trabecular loss in ovariectomised rats, without any effects observed on bone cortical thickness. Nevertheless, bone loss prevention using different stimulation intensities, frequencies and exposition times, have been reported [Basset et al, 1979;Cruess et al, 1983;Mishima, 1988;Simske et al, 1991;Skerry et al, 1991;Takayama et al, 1990;Yan et al, 1998]. In recent studies concerning PEMF influence upon bone cell cultures, both osteoblasts [Diniz et al, 2002;Chang et al, 2004a] and osteoclasts [Shankar et al, 1998;Chang et al, , 2004b were affected.…”

mentioning

confidence: 99%

Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat

Márquez‐Gamiño

Sotelo

Sosa

et al. 2008

Bioelectromagnetics

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The effect of 1 Hz, 30 mT pulsed magnetic fields on young adult rat femoral metaphyseal bone thickness was assessed. Ten same litter, female Wistar rats were studied; five of them underwent 30 min magnetic stimulation sessions for 20 consecutive days. The anterior and posterior cortical, as well as trabecular bone transverse thicknesses were measured. The results obtained under clear field microscopy in stimulated and control histological cuts were (in microm) 398 +/- 32 versus 260 +/- 22 (P = 0.002), 380 +/- 68 versus 252 +/- 21 (P = 0.03), and 168 +/- 11 versus 112 +/- 11 (P = 0.002), respectively. The transcranial magnetic stimulation system, approved for human therapy, generates pulsed electromagnetic fields, which induce a significant thickness increase in cortical and trabecular in vivo stimulated bone tissues. This is the first time this effect in healthy animals is shown.

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The Effect of Pulsing Electromagnetic Fields on Bone Metabolism in Experimental Disuse Osteoporosis

Cited by 50 publications

References 1 publication

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process

Osteoprotegerin ameliorates sciatic nerve crush induced bone loss

Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat

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The Effect of Pulsing Electromagnetic Fields on Bone Metabolism in Experimental Disuse Osteoporosis

Cited by 50 publications

References 1 publication

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E2‐associated process

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E2‐associated process

Osteoprotegerin ameliorates sciatic nerve crush induced bone loss

Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat

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Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: A prostaglandin E₂‐associated process