The effect of quercetin delivery system on osteogenesis and angiogenesis under osteoporotic conditions

Zhou, Yifeng; Wang, Yuqiong; Ma, Wudi; Jiang, Xinquan; Takemra, Akimichi; Uemura, Mamoru; Xia, Lunguo; Lin, Kaili; Xu, Yinghong

doi:10.1039/c6tb02312f

Cited by 62 publications

(52 citation statements)

References 44 publications

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“…It was implanted into a bone defect created at the distal region of the femur diaphysis in ovariectomised rats. It was noted that the BMD and Tb.Th of the bone defects were improved after eight weeks of implantation [34].…”

Section: Type Of Animalmentioning

confidence: 91%

“…MSCs are adult stem cells capable of differentiating into osteoblasts, chondrocytes, myocytes, adipocytes, neurocytes and hepatocytes [100]. Using rat or mouse bone-marrow-derived MSCs, quercetin in various concentrations promoted proliferation, differentiation and mineralisation into osteoblastic lineage with a concomitant increase in the expression of ALP, osterix, Runx-2, COL1, BMP-2, BSP, osteopontin, osteocalcin, TGF-β1 and Cbfα1 [34,[62][63][64][65]. Adipose-derived stem cells are MSCs derived from adipose tissues.…”

Section: The Effects Of Quercetin On Osteoblastogenesismentioning

confidence: 99%

“…The effects of quercetin on the expression of osteoprotegerin and RANKL have been widely demonstrated. In the osteoblast-like cells, the differential expression of osteoprotegerin and RANKL was observed (where the osteoprotegerin level was increased or unchanged but the RANKL level was decreased), resulting in an increase in osteoprotegerin/RANKL ratio in the presence of quercetin [34,65], quercitrin [82,83] or extract enriched with quercetin [73]. A similar trend of osteoprotegerin and RANKL expression along with the decrease in CTSK was seen when osteoblast-osteoclast-endothelial cell triculture was seeded on hydroxyapatite loaded with quercetin.…”

Section: Regulation Of the Receptor Activator Of Nuclear Factor-kappamentioning

confidence: 99%

“…The data presented by Prouillet et al (2004) showed that the activation of ERK by quercetin was most likely downstream of the oestrogen-receptor activation [69]. Quercetin exerted dual actions on p38 MAPK to promote osteogenic proliferation and differentiation in MSCs upon its activation, as well as suppressing apoptosis in MC3T3-E1 cells following its inhibition [34,62,63,75]. For the JNK pathway, some studies have reported that quercetin might activate, inhibit or exert negligible effects on osteoblasts.…”

Section: Regulation Of Mapk Signallingmentioning

confidence: 99%

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Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Wong

Chin

2020

IJMS

143

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Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide spectrum of biological activities, thus suggesting a role in disease prevention and health promotion. The present review aimed to uncover the bone-sparing effects of quercetin and its mechanism of action. Animal studies have found that the action of quercetin on bone is largely protective, with a small number of studies reporting negative outcomes. Quercetin was shown to inhibit RANKL-mediated osteoclastogenesis, osteoblast apoptosis, oxidative stress and inflammatory response while promoting osteogenesis, angiogenesis, antioxidant expression, adipocyte apoptosis and osteoclast apoptosis. The possible underlying mechanisms involved are regulation of Wnt, NF-κB, Nrf2, SMAD-dependent, and intrinsic and extrinsic apoptotic pathways. On the other hand, quercetin was shown to exert complex and competing actions on the MAPK signalling pathway to orchestrate bone metabolism, resulting in both stimulatory and inhibitory effects on bone in parallel. The overall interaction is believed to result in a positive effect on bone. Considering the important contributions of quercetin in regulating bone homeostasis, it may be considered an economical and promising agent for improving bone health. The documented preclinical findings await further validation from human clinical trials.

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Section: Type Of Animalmentioning

confidence: 91%

Section: The Effects Of Quercetin On Osteoblastogenesismentioning

confidence: 99%

Section: Regulation Of the Receptor Activator Of Nuclear Factor-kappamentioning

confidence: 99%

Section: Regulation Of Mapk Signallingmentioning

confidence: 99%

See 2 more Smart Citations

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Wong

Chin

2020

IJMS

143

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“…We have previously shown that quercetin-functionalized hydroxyapatite can be useful for a local administration of the flavonoid since it enhances human OB-like cells proliferation and differentiation, whereas it downregulates osteoclasteogenesis 13 . Moreover, a recent study on in vitro and in vivo behavior of quercetin-loaded HA nanospheres, which has been performed on ovariectomized rat bone marrow derived mesenchymal stem cells and critical-sized femur defect model, indicates that the material could promote osteogenesis and angiogenesis, while inhibiting osteoclastogenesis, under osteoporotic conditions 14 . The results of a study on 3D porous calcium deficient hydroxyapatite scaffolds loaded with quercetin suggested that the beneficial influence of the flavonoid on bone tissue regeneration might be even greater than that of alendronate, one of the most potent bisphosphonates (BPs) 15 .…”

Section: Introductionmentioning

confidence: 99%

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Forte

Torricelli

Boanini

et al. 2017

J Biomedical Materials Res

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In spite of its remarkable anti-oxidant, anti-inflammatory, anti-cancer properties and its possible inhibition activity towards bone resorption, quercetin therapeutic use is limited by its poor bioavailability. Herein we developed a new multifunctionalized system for the local administration of quercetin and alendronate, one of the most potent anti-osteoporotic drugs, with the aim to get a material with enhanced properties. To this purpose we loaded quercetin on hydroxyapatite functionalized with alendronate, as well as on hydroxyapatite. Characterization was performed by means of X-ray diffraction, FT-IR and Raman spectroscopies, thermogravimetric and spectrophotometric analyses. Loading of quercetin from hydro-alcoholic solution increased with time and reached a constant value of about 5 weight% on both substrates, without causing significant structural and morphological modifications. Quercetin functionalized materials exhibit relevant anti-oxidant properties, in agreement with their high radical scavenging activity, and a quercetin sustained release in phosphate buffer. In vitro osteoblast and osteoclast co-culture in a microenvironment altered by oxidative stress shows that both alendronate and quercetin significantly reduce osteoclast viability, whereas they are able to counteract the negative effect of oxidative stress on osteoblast viability and differentiation, suggesting that their relative amount in the functionalized materials can be utilized to tailor bone cells response. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3293-3303, 2017.

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Quercetin‐Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects

Zhu,

Cai,

et al. 2024

Advanced Science

Self Cite

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Periodontal disease ranks third among noncommunicable illnesses, behind cancer and cardiovascular disease, and is closely related to the occurrence and progression of various systemic diseases. However, elucidating the processes of periodontal disease and promoting periodontal bone regeneration remains a challenge. Here, quercetin is demonstrated to reduce the oxidative stress state of orofacial mesenchymal stem cells (OMSCs) in vitro and to affect the osteogenic growth of OMSCs through molecular mechanisms that mediate the m6A change in Per1. Nevertheless, the limited therapeutic efficacy of systemic medication and the limitations of local medication resulting from the small, moist, and highly dynamic periodontal environment make it challenging to treat periodontal tissues with medication. Herein, a biosafe injectable hydrogel drug‐controlled delivery system is constructed as a bone‐enhancing factory and loaded with quercetin to treat oxidative stress injury in periodontal tissues. This drug‐carrying system made up of nanoscale bioglass microspheres and a light‐cured injectable hydrogel, allows effective drug particle loading and cementation in the dynamic and moist periodontal environment. Furthermore, the system demonstrates the ability to stimulate OMSCs osteogenic differentiation in a Per1‐dependent manner, which ultimately promotes periodontal bone repair, suggesting that this system has potential for clinical periodontal therapy.

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The effect of quercetin delivery system on osteogenesis and angiogenesis under osteoporotic conditions

Abstract: Bone regeneration under osteoporotic conditions with impaired angiogenesis, osteogenesis and remodeling represents a great challenge.

Cited by 62 publications

References 44 publications

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence

Quercetin and alendronate multi‐functionalized materials as tools to hinder oxidative stress damage

Quercetin‐Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects

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