The Effect of Red Betel Leaf (Piper crocatum) and Moringa Leaf Extracts on Endometritis Levels in Aceh Cows

Abstract

This study aims to determine the ability of red betel leaf (Piper crocatum) or Moringa leaf extracts to reduce the endometritis level in Aceh cattle. In this study, six Aceh cows aged 3-5 years, weighing 150-250 kg from the Experimental Animal Technical Implementation Unit of Faculty of Veterinary Medicine of Syiah Kuala University were used. The cows were divided into two treatment groups, namely cows with endometritis that were given red betel leaf extract (T1) and cows with endometritis that were given Moringa leaf extract (T2). Examination of the endometritis levels was carried out before and after treatment using the White Side Test (WST) method. The collection of estrus cervical mucus was needed for the WST examination, and heat induction was performed with prostaglandin F2 alpha (PGF2α) at a dose of 25 μg. Collection of cervical mucus was performed 8-12 hours after the initiation of heat. All cows with endometritis were given intrauterine extracts of red betel leaves or Moringa leaves at a concentration of 20% every 24 hours for a week at a solution volume of 20 ml. The data were then analyzed using a paired t test. The mean endometritis levels before and after treatment on K1 vs. K2 were 3.0 and 1.7 vs. 2.7 and 2.7, respectively (P<0.05). It was concluded that red betel leaf extract at a concentration of 20% was more effective in reducing the endometritis level of Aceh cows than Moringa leaf extract.

Piper crocatum Ameliorates APAP-Induced Hepatotoxicity through Antioxidant and Anti-Inflammatory Mechanisms

“…Based on Morsy et al (2020), piperine in Piper nigrum has antiinflammatory and anti-apoptotic actions in the liver through lowering nuclear factor kappa B (NF-kB) p65 expression and modulating hepatic caspase3 and Bcl2, and also enhanced hepatic TGFBRAP1 expression [16]. Red betel containing eugenol [14][30] [31], which has antioxidant activities [14], helps maintain the GSH level during oxidative stress in the hepatotoxicity process [32]. Treatments B Eugenol showed hepatoprotective potential on the APAP-induced HepG2 cells model by decreasing the LDH, AST and ALT activities [17].…”

Endometritis Control and Enhanced Reproductive Performance in Aceh Cow Using Medicinal Plants

“…The use of medicinal plants for the treatment of endometritis and endometriosis in animal models has been studied previously (Wardani et al, 2017;Hafsari and Pujiastutik, 2018;Sharma et al, 2018;Bina et al, 2019). Treatment and control of endometritis in Aceh cattle had been carried out by Rosmaidar et al (2021) using red betel leaf and moringa leaf extract. However, the study was limited to analyzing the decrease in endometritis levels using the White Side Test (WST).…”

“…In this study, apart from the WST test, total bacterial colony counts and reproductive performance were also observed after treatment. In addition, the plant extracts used in this study were prepared by a subsequent maceration process, while Rosmaidar et al (2021) used a simple extraction process using maceration with ethanol. Therefore, the purpose of this study was to evaluate the efficacy of betel leaf, moringa leaf, and garlic extracts as therapy for endometritis in Aceh cows.…”