The effect of reduced physical activity on longevity of mice

Mlekusch, Walter; Tillian, H. M.; Lamprecht, Manfred; Trutnovsky, H.; Horejsi, Renate; Reibnegger, Gilbert

doi:10.1016/0047-6374(96)01734-4

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…In addition, the majority of studies have found positive correlations between physical activity and longevity in rodents (Bronikowski et al, ; Holloszy, ; Holloszy, Smith, Vining, & Adams, ; Lokkegaard, Larsen, & Christensen, ; Mlekusch et al, ; Vogel et al, ) as well as humans (Lokkegaard et al, ; Rizzuto & Fratiglioni, ; Vogel et al, ). In normal weight individuals, regular physical activity has been estimated to extend life by 7.2 years, and conversely, inactivity to decrease life by 3.1 years (Moore et al, ).…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic mTORC2 is essential for metabolic health and longevity

et al. 2019

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The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved protein kinase that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 and mTORC2, that have distinct components and substrates and are both inhibited by rapamycin, a macrolide drug that robustly extends lifespan in multiple species including worms and mice. Although the beneficial effect of rapamycin on longevity is generally attributed to reduced mTORC1 signaling, disruption of mTORC2 signaling can also influence the longevity of worms, either positively or negatively depending on the temperature and food source. Here, we show that loss of hypothalamic mTORC2 signaling in mice decreases activity level, increases the set point for adiposity, and renders the animals susceptible to diet‐induced obesity. Hypothalamic mTORC2 signaling normally increases with age, and mice lacking this pathway display higher fat mass and impaired glucose homeostasis throughout life, become more frail with age, and have decreased overall survival. We conclude that hypothalamic mTORC2 is essential for the normal metabolic health, fitness, and lifespan of mice. Our results have implications for the use of mTORC2‐inhibiting pharmaceuticals in the treatment of brain cancer and diseases of aging.

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Section: Discussionmentioning

confidence: 99%

Hypothalamic mTORC2 is essential for metabolic health and longevity

et al. 2019

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“…In another study, restricting exercise led to higher body weights, lower metabolism, and an earlier time of death [14] . Similarly, Holloszy [15] found that in rats average longevity was increased in exercised individuals.…”

Section: Changes In Physiology During Ageingmentioning

confidence: 99%

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu

Valencak

2017

Gerontology

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The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity.

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“…For example, vigorous exercise training in humans and other mammals has been shown to increase cognitive capacity (Suominen-Troyer et al, 1986), locomotor performance (Skalicky et al, 1996), motor coordination (Dorner et al, 1997), antioxidant capacity (Gündüz et al, 2004;Kayani et al, 2008), resistance to cellular oxidative damage (Radák et al, 1999), immune function (Utsuyama et al, 1996) and lifespan (Paffenbarger et al, 1993;Lee and Paffenbarger, 2000). Alternatively, prolonged sedentarism in otherwise active mammal species can decrease running capacity (Swallow et al, 1998), lower the maximum rate of O 2 uptake (Overton et al, 1986;MacNeil and Hoffman-Goetz, 1993), increase body mass (Mlekusch et al, 1996;Swallow et al, 1998) and decrease lifespan (Goodrick, 1980;Holloszy, 1988;Franco et al, 2005;Bronikowski et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The effects of age and lifetime flight behavior on flight capacity inDrosophila melanogaster

Frankino

Elekonich

Roberts

2014

Journal of Experimental Biology

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The effects of flight behavior on physiology and senescence may be profound in insects because of the extremely high metabolic costs of flight. Flight capacity in insects decreases with age; in contrast, limiting flight behavior extends lifespan and slows the age-related loss of antioxidant capacity and accumulation of oxidative damage in flight muscles. In this study, we tested the effects of age and lifetime flight behavior on flight capacity by measuring wingbeat frequency, the ability to fly in a hypo-dense gas mixture, and metabolic rate in Drosophila melanogaster. Specifically, 5-day-old adult flies were separated into three life-long treatments: (1) those not allowed to fly (no flight), (2) those allowed -but not forced -to fly (voluntary flight) and (3) those mechanically stimulated to fly (induced flight). Flight capacity senesced earliest in flies from the no-flight treatment, followed by the induced-flight group and then the voluntary flight group. Wingbeat frequency senesced with age in all treatment groups, but was most apparent in the voluntary-and induced-flight groups. Metabolic rate during agitated flight senesced earliest and most rapidly in the induced flight group, and was low and uniform throughout age in the no-flight group. Early senescence in the induced-flight group was likely due to the acceleration of deleterious aging phenomena such as the rapid accumulation of damage at the cellular level, while the early loss of flight capacity and low metabolic rates in the no-flight group demonstrate that disuse effects can also significantly alter senescence patterns of whole-insect performance.

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The effect of reduced physical activity on longevity of mice

Cited by 10 publications

References 22 publications

Hypothalamic mTORC2 is essential for metabolic health and longevity

Hypothalamic mTORC2 is essential for metabolic health and longevity

Energy Metabolism and Ageing in the Mouse: A Mini-Review

The effects of age and lifetime flight behavior on flight capacity inDrosophila melanogaster

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