The Effect of Resection of the Olfactory, Gustatory and Trigeminal Nerves on Water Drinking in Dogs Without and With Diabetes Insipidus

Bellows, Rowland T.; Wagenen, William P. Van

doi:10.1152/ajplegacy.1939.126.1.13

Cited by 14 publications

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“…provide only indirect evidence on the role of orosensory inputs, by manipulating diet palatability (e.g., Le Magnen, 1971;Peck, 1978), bypassing orosensory receptors (e.g., Altar & Carlisle, 1979;Snowdon, 1969), or disrupting orogastric contingencies (e.g., Blass & Hall, 1976;Davis & Levine, 1977). With the exception of a few early studies (Bellows & van Wagenen, 1939;Pfaffmann, 1952;Richter, 1956), little use has been made of the deafferentation experiment, the traditional physiological procedure for assessing the contribution of afferent mechanisms to the control of specific behaviors.…”

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confidence: 99%

Trigeminal orosensation and ingestive behavior in the rat.

Zeiguer¹,

Jacquin²,

Miller³

1983

Behavioral Neuroscience

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A deafferentation procedure was used to examine the contributions of trigeminal orosensation to the control of ingestive behavior in the rat. The procedure removed somatosensory input from the mouth, sparing olfaction, lingual taste, and vibrissae inputs as well as proprioceptive afferents from and efferents to the jaw muscles. Rats with sections of tongue or jaw muscle efferents served as oromotor controls. Bilateral trigeminal orosensory deafferentation was followed by an array of effects on ingestive behavior whose magnitudes were proportional to the extent of the deafferentation. The "trigeminal syndrome" includes a disruption of food and water intake (aphagia, adipsia), impairments in the sensorimotor control of eating and drinking, decreased responsiveness to food and water, and a reduction in the level of body weight regulation. Trigeminal deafferentation spared elementary ingestive movement patterns (biting, licking, chewing) but disrupted their control by the perioral stimuli, which normally elicit them, so that eating and drinking sequences were either aborted or inefficient. Deficits in food intake varied with the sensory properties of the diet. Recovery of intake took place along a palatability gradient, and recovery of water intake paralleled that of dry food. The chronically reduced body weight was caused by a persistent hypophagia and reflects reduced responsiveness to food. These findings suggest a considerable degree of overlap in the neural mechanisms mediating the sensorimotor and motivational control of intake in the rat.

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mentioning

confidence: 99%

Trigeminal orosensation and ingestive behavior in the rat.

Zeiguer¹,

Jacquin²,

Miller³

1983

Behavioral Neuroscience

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“…The notion that thirst is mediated by a local stimulus or stimuli confined to the oral cavity has also been investigated by observing the effects of oral anesthesia or denervation on water intake. Bellows and Van Wagenen (1939) failed to note any changes in water intake in dogs with bilateral divisions of the trigeminal, glossopharyngeal and chorda tympani, or olfactory tract, but Valenti (1909) found that cocaine applied to the oral cavity, throat, and upper esophagus completely inhibited drinking in water-deprived dogs. In humans, locally anesthetizing the oral cavity appears to have little effect on the water intake of individuals with diabetes insipidus (Rowntree, 1922), nor does it reduce the thirst of hypernatremia (Leschke, 1918).…”

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Observations on the role of salivary secretions in the regulation of food and fluid intake in the white rat.

Vance¹

1965

Psychological Monographs: General and Applied

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Observations on the food and water intake, specific hunger, and taste preference behavior of rats made desalivate by ligation of the principal salivary ducts are described. Desalivate rats drink excessive amounts of water when feeding on a dry diet, which is attributed to the use of drinking water as an exogenous saliva to facilitate the swallowing of dry food. The feeding pattern of desalivate rats is strikingly similar to that seen in animals recovered from lateral hypothalamic lesions, suggesting that these lesions disrupt normal salivary secretions. Changes in the preference behavior for sodium chloride solutions, quinine rejection thresholds, and the sucrose preference of pancreatectomized and adrenalectomized rats following desalivation strongly suggest that alterations in salivary composition may alter the peripheral taste receptor response and thereby the volume intake of substances which normally stimulate the receptors in the course of ingestion.The role of salivary secretions in the regulation of food and fluid intake has been considered almost exclusively in connection with Cannon's theory of thirst, which maintained that thirst was synonymous with a dryness of the oral cavity normally resulting from a reduced salivary flow (Cannon, 1918). This xerostomic, or dry mouth, view of thirst has been espoused more recently by Gregerson and Cizek (1961) who, after reviewing the several factors giving rise to an increased water intake, conclude that, "The common factor ... in all forms of thirst examined appears to be a reduction in salivary flow [p. 325]."The "dry mouth" theory, however, has received anything but unqualified experimental support (for review, see Wolf, 1958). Despite a sizable literature on xerostomia and water intake, only a few studies have dealt with desalivate animals. Bidder and Schmidt (1852) found an enhanced water intake in desalivate dogs, and Gre-

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The Hypothalamus and Affective Behavior in Cats

Wheatley¹

1944

Arch NeurPsych

253

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The Effect of Resection of the Olfactory, Gustatory and Trigeminal Nerves on Water Drinking in Dogs Without and With Diabetes Insipidus

Cited by 14 publications

References 0 publications

Trigeminal orosensation and ingestive behavior in the rat.

Trigeminal orosensation and ingestive behavior in the rat.

Observations on the role of salivary secretions in the regulation of food and fluid intake in the white rat.

The Hypothalamus and Affective Behavior in Cats

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