The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis

Jiang, Qiang; Lou, Kai; Hou, Lulu; Lu, Yong; Sun, Lizhi; Tan, Shing Cheng; Low, Teck Yew; Kord‐Varkaneh, Hamed; Pang, Shuguang

doi:10.1016/j.ctim.2020.102360

Cited by 44 publications

(27 citation statements)

References 52 publications

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“…IGF-1 is a regulator of the phosphoinositide 3-kinase and protein kinase B pathway and is widely considered required for activating the signal transduction for the initiation of muscle protein synthesis following mechanical loading (27) . In agreement with our findings, a recent systematic review and meta-analysis reports the positive association of increments of IGF-1 with resistance training (54) . Interestingly, despite resistance training clearly altering several known regulators of muscle accretion, we only found one modest correlation (r 2 = 0•160; P = 0•035) between the change in Activin A and lean mass.…”

Section: Discussionsupporting

confidence: 93%

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males

et al. 2021

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Due to the important roles of resistance training and protein consumption in the prevention and treatment of sarcopenia, we assessed the efficacy of post-exercise Icelandic yogurt consumption on lean mass, strength, and skeletal muscle regulatory factors in healthy untrained older males. Thirty healthy untrained older males (age = 68 ± 4 yr) were randomly assigned to Icelandic yogurt (IR; n =15, 18 g of protein) or an iso-energetic placebo (PR; n =15, 0 g protein) immediately following resistance training (3x/week) for eight weeks. Before and after training, lean mass, strength, and skeletal muscle regulatory factors (insulin-like growth factor-1 [IGF-1], transforming growth factor-beta 1 [TGF-β1], growth differentiation factor 15 [GDF15], Activin A, myostatin [MST], and follistatin [FST]) were assessed. There were group x time interactions (p < 0.05) for body mass (IR: Δ 1, PR: Δ 0.7 kg), body mass index (IR: Δ 0.3, PR: Δ 0.2 kg∙m−2), lean mass (IR: Δ 1.3, PR: Δ 0.6 kg), bench press (IR: Δ 4, PR: 2.3 kg), leg press (IR: Δ 4.2, PR: Δ 2.5 kg), IGF-1 (IR: Δ 0.5, Δ PR: 0.1 ng∙mL−1), TGF-β (IR: Δ −0.2, PR: Δ −0.1 ng∙mL−1), GDF15 (IR: Δ −10.3, PR: Δ −4.8 pg∙mL−1), Activin A (IR: Δ −9.8, PR: Δ −2.9 pg∙mL−1), MST (IR: Δ −0.1, PR: Δ −0.04 ng∙mL−1), and FST (IR: Δ 0.09, PR: Δ 0.03 ng∙mL−1), with Icelandic yogurt consumption resulting in greater changes compared to placebo. The addition of Icelandic yogurt consumption to a resistance training program improved lean mass, strength, and altered skeletal muscle regulatory factors in healthy untrained older males compared to placebo. Therefore, Icelandic yogurt as a nutrient-dense source and cost-effective supplement enhances muscular gains mediated by resistance training and consequently may be used as a strategy for the prevention of sarcopenia.

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Section: Discussionsupporting

confidence: 93%

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males

et al. 2021

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“…It has been suggested -and partially demonstrated-, that aerobic exercise increases the neuronal activity that increases intracellular calcium, which further enhances BDNF synthesis and release ( Fernandes et al, 2017 ). The exercise program also included strength exercises, and recent meta-analytical evidence shows that resistance training exercise increases insulin-like growth factor-1 (IGF-1) synthesis in skeletal muscle in male and female older adults ( Jiang et al, 2020 ; Ye et al, 2021 ). This anabolic molecule reaches the brain to induce BDNF production ( Herold et al, 2019 ; Pinho et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency

Canton-Martínez

Rentería

García-Suárez

et al. 2022

Front. Aging Neurosci.

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BackgroundHuman brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults.MethodsNineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m2) completed either a three times/week (3-t/w) (n = 8) or five times/week (5-t/w) (n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program.ResultsRegardless of the group, the serum BDNF increased following the intervention (p < 0.001), and there were no significant group (p = 0.827) or interaction (p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p = 0.007), with a non-significant group (p = 0.722) or interaction (p = 0.223) effects. Upper- and lower-body strength increased in both groups (p = 0.003); however, there was no effect of the training frequency (p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p = 0.053). Finally, the body fat percentage was unchanged.ConclusionEleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults.

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“…The inconsistent conclusions may be explained by the fact that the author chose a simpler and single form of aerobic physical exercise, which only required the completion of a few simple prescribed movements, and the effect of the exercise form on shifting function was smaller. In addition, molecular and cellular mechanism studies found that exercise elevates peripheral brainderived neurotrophic factor and insulin-like growth factor 1 levels, increases vascular endothelial growth factor and serotonin concentrations and stimulates hippocampal neurogenesis, thereby promoting executive function [50,51] . Structural and functional changes in the brain can also mediate enhanced cognitive performance after exercises, such as increased volume of the hippocampus, gray matter, and white matter, improved integrity of white matter, and increased functional connectivity of frontal executive networks [52] .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Physical Activity Level on Trait Anxiety in College Students: The Mediating Role of Executive Function

DONG

Wang

Xin

et al. 2022

Preprint

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Objectives: This study aimed to analyze the relationship between physical activity level, executive function, and trait anxiety and focused on investigating the mediating role of the subcomponents of executive functions between different levels of physical activity intensity and trait anxiety.Methods: The International Physical Activity Questionnaire, State-Trait Anxiety Inventory, Stroop task, 1-back task, and More-odd shifting task were used to analyze 248 college students by one-way ANOVA, linear regression analysis, and structural equation modeling analysis.Results: Trait anxiety were significantly correlated with shifting function (r=0.182, P=0.004) and inhibition function (r=0.163, P=0.010) and not with working memory (r=0.056, P=0.385). High-intensity physical activity level was most highly correlated with inhibition function (Beta=-0.144, P=0.024) and working memory (Beta=-0.208, P=0.001), and low-intensity physical activity level was most highly correlated with shifting function (Beta=-0.211, P=0.001). Physical activity level had a 72.31% direct effect on reducing trait anxiety (B=-0.195), with 11.79% mediated by inhibition function (B=-0.023) and 15.90% by shifting function (B=-0.031). High-intensity physical activity level had a direct effect on alleviating trait anxiety in 81.08% (B=-0.150), 9.19% mediated by inhibition function (B=-0.017), and 9.73% mediated by shifting function (B=-0.018). The effect of medium-intensity physical activity level on trait anxiety was 40.91% mediated by inhibition function (B=-0.018) and 56.82% mediated by shifting function (B=0.025). The effect of the low-intensity physical activity level on trait anxiety was mediated 34.62% by inhibition function (B=-0.018) and 65.38% by shifting function (B=-0.034).Conclusion: College students with trait anxiety suffer from impaired inhibition and shifting function. The facilitation effects of physical activity levels on executive function subcomponents were, in descending order, working memory, shifting function, and inhibition function, with high-intensity physical activity level contributing most to the facilitation of working memory and inhibition function, and low-intensity physical activity level contributing most to the promotion of shifting function. Physical activity promotes both inhibition and shifting functions, which in turn affect trait anxiety. The high-intensity physical activity level has a direct effect on trait anxiety, while the anxiolytic effect of medium and low-intensity physical activity level is mediated exclusively through executive functions, with the highest mediating effect of shifting function.

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The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis

Cited by 44 publications

References 52 publications

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males

Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency

The Effect of Physical Activity Level on Trait Anxiety in College Students: The Mediating Role of Executive Function

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